The study, “A Clinical Evaluation to Determine the Safety, Pharmacokinetics and Pharmacodynamics of an Inositol-Stabilized Arginine Silicate Dietary Supplement in Healthy Adult Males” demonstrated significant increases in plasma arginine levels (P<0.01) and serum silicon levels (P<0.01) after a single dose of Nitrosigine. In addition, a significant increase in nitric oxide levels (measured as salivary nitrites) was seen after 14 days of product consumption (P<0.05). The results of the clinical study support the use of Nitrosigine as a bioavailable source of arginine and silicon, validating the preclinical studies and confirming Nitrosigine as an effective ingredients in products for sports nutrition, men’s health and cardiovascular health.
The clinical study also found that daily Nitrosigine supplementation increased nitric oxide (NO) levels with a significant change in NO levels between the first treatment visit and after 14 days. The increase in NO levels can promote relaxation of smooth muscle in blood vessels, which increases blood flow and improves cardiovascular and muscular health.
James Komorowski, MS, CNS, vice president, Scientific & Regulatory Affairs of Nutrition 21 commented, “We are immensely pleased with the new clinical results. The clinical study confirms our pre-clinical work, and supports Nitrosigine’s ability to optimize the benefits of rigorous workouts by significantly increasing nitric oxide levels. Fitness-focused customers who want to get the most out of their training regimen, will appreciate that Nitrosigine is quickly absorbed by the body, taking effect in 30 minutes and lasting up to three hours. Nitrosigine has also been shown to significantly raise arginine and silicon levels - both important nutrients for cardiovascular performance.”