12.14.21
BeniCaros, a carrot derived RG-1 (Rhamnogalacturonan-I) ingredient from Nutrileads, was evidenced in a recent in vitro study to exert activities in the human gut microbiome beneficial to immune function and gut health.
RG-I, a complex pectin-derived polysaccharide purified from carrot pomace, was introduced to an in vitro dynamic model of the human gut called SHIME (Simulator of Human Intestinal Microbial Ecosystem), an in vitro model made by German contract research organization ProDigest which is the only to integrate the entire GI transit into one system. After it was introduced to 4 donor fecal microbiota in parallel, analysis demonstrated that RG-I consistently modified bacterial populations despite the variability seen between the subjects in areas such as short-chain fatty acids.
The results supported previous notions that RG-I is metabolized by a distinct bacterial consortium which includes Bacteroidetes, Prevotella, and Bifidobacterium species. It is also linked to increased production of short-chain fatty acids. Additionally, the study further confirmed a dual mode of action seen in previous studies on the immune system and microbiota.
“The results of the SHIME study are fundamental to our ongoing research into BeniCaros and the underlying mechanisms that drive its powerful immune health benefits,” Dr. Ruud Albers, CSO of Nutrileads, said. “Our data shows that BeniCaros can help product manufacturers to deliver a more well-rounded immune health solution to consumers, and they will be able to feel the difference.”
Based on years of pre-clinical and clinical studies, BeniCaros is shown to have immunostimulatory effects, while also leading to increased production of a number of immune-related metabolites.
BeniCaros is a soluble fiber sourced from carrot pomace through a proprietary process, as a side stream of carrot juice production. It is a tasteless and odorless powder that does not use artificial additives, making it a label friendly ingredient. BeniCaros can be formulated into most functional food, beverages, and supplement formats.
RG-I, a complex pectin-derived polysaccharide purified from carrot pomace, was introduced to an in vitro dynamic model of the human gut called SHIME (Simulator of Human Intestinal Microbial Ecosystem), an in vitro model made by German contract research organization ProDigest which is the only to integrate the entire GI transit into one system. After it was introduced to 4 donor fecal microbiota in parallel, analysis demonstrated that RG-I consistently modified bacterial populations despite the variability seen between the subjects in areas such as short-chain fatty acids.
The results supported previous notions that RG-I is metabolized by a distinct bacterial consortium which includes Bacteroidetes, Prevotella, and Bifidobacterium species. It is also linked to increased production of short-chain fatty acids. Additionally, the study further confirmed a dual mode of action seen in previous studies on the immune system and microbiota.
“The results of the SHIME study are fundamental to our ongoing research into BeniCaros and the underlying mechanisms that drive its powerful immune health benefits,” Dr. Ruud Albers, CSO of Nutrileads, said. “Our data shows that BeniCaros can help product manufacturers to deliver a more well-rounded immune health solution to consumers, and they will be able to feel the difference.”
Based on years of pre-clinical and clinical studies, BeniCaros is shown to have immunostimulatory effects, while also leading to increased production of a number of immune-related metabolites.
BeniCaros is a soluble fiber sourced from carrot pomace through a proprietary process, as a side stream of carrot juice production. It is a tasteless and odorless powder that does not use artificial additives, making it a label friendly ingredient. BeniCaros can be formulated into most functional food, beverages, and supplement formats.
