• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Researchers Develop New Global Estimate of Medicinal Plant Species and Conservation Status

    All Eyes on Vision Health

    Health Benefits of Vitamin K: A Contemporary Cornerstone of Heart and Bone Health

    Vitamin D: A Fixture of Supplementation and Fortification

    Magnesium: An Essential Mineral with Many Forms and Functions
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Glossary
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    Probiotics Supplementation Reduces Complications in Colorectal Cancer Patients

    Vitamin D Supplementation Reduces Risk of Dynapenia

    Sustained-Release Caffeine Ingredient Offers Mood, Performance Benefits

    Multi-Strain Probiotic Improves Self-Reported Mood, Sleep, Serotonin Levels

    CRN Highlights 'Supplement to Savings' Report for National Heart Month
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    Probiotics Supplementation Reduces Complications in Colorectal Cancer Patients

    FDA Denies CBD Petitions, Cites Safety Concerns, Looks to Congress for New Regulatory Pathway

    Vitamin D Supplementation Reduces Risk of Dynapenia

    Sustained-Release Caffeine Ingredient Offers Mood, Performance Benefits

    Multi-Strain Probiotic Improves Self-Reported Mood, Sleep, Serotonin Levels
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    Probiotics Supplementation Reduces Complications in Colorectal Cancer Patients

    FDA Denies CBD Petitions, Cites Safety Concerns, Looks to Congress for New Regulatory Pathway

    Vitamin D Supplementation Reduces Risk of Dynapenia

    Sustained-Release Caffeine Ingredient Offers Mood, Performance Benefits

    Multi-Strain Probiotic Improves Self-Reported Mood, Sleep, Serotonin Levels
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    Probiotics Supplementation Reduces Complications in Colorectal Cancer Patients

    Vitamin D Supplementation Reduces Risk of Dynapenia

    Sustained-Release Caffeine Ingredient Offers Mood, Performance Benefits

    Multi-Strain Probiotic Improves Self-Reported Mood, Sleep, Serotonin Levels

    CRN Highlights 'Supplement to Savings' Report for National Heart Month
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    KLK OLEO

    JRS Pharma

    Bioenergy Life Science, Inc. (BLS)

    Botanic Healthcare LLC

    Sabinsa Corporation
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    KLK OLEO

    JRS Pharma

    Bioenergy Life Science, Inc. (BLS)

    Botanic Healthcare LLC

    Sabinsa Corporation
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Breaking News

    Curcumin Formulation Study Confirms Enhanced Bioavailability

    Curcugen curcumin extract offered 39-fold enhanced bioavailability capabilities over conventional curcuminoids 95%.

    Curcumin Formulation Study Confirms Enhanced Bioavailability
    Related CONTENT
    • Healthy, Clean Label Snacks and Nutrition Bars Help Fill Nutrient Gap Cleaved By Modern Lifestyles
    • Magnesium: An Essential Mineral with Many Forms and Functions
    • All Eyes on Vision Health
    • Euromonitor Reveals Top 10 Global Consumer Trends
    • FDA to Allow Vitamin D3 as Additive in Cereals, Grain-Based Bars
    07.23.21
    Pharmacokinetic data supported a 39-fold-enhanced bioavailability of free curcumin claim for DolCas Biotech, LLC’s Curcugen curcumin extract. The 17-subject randomized, double-blind, crossover study published in the journal Medicine evaluated the dispersible, 98.5% native turmeric (50% curcuminoid concentrate) formulation, against conventionally extracted C-95 (also a 95% curcuminoid extract) to determine the degree of enhanced absorption by the patented brand.
     
    In concentrating curcuminoids to a 50% standard, Curcugen uniquely co-extracts turmeric-native resins that are polar in nature and offers the patented “Self-D” bioenhancer-like benefits that facilitate dispersibility. Owing to its 98.5% turmeric-derived base, Curcugen also prioritizes the presence of other turmeric natives, like polysaccharides and essential oils, which, through enhancement of the brand’s dispersion characteristics, contribute additional value to both bioavailability and bioactivity.
     
    Prior research suggests that enhanced free curcumin is directly linked to the compound’s ability to circumvent the inherent resistance unformulated curcuminoids encounter entering the bloodstream and target tissues. Free curcumin analysis is a direct measurement of the proportion of curcumin ingested that is absorbed across the intestinal barrier and found intact in the plasma.
     
    “While Curcugen is not the first curcuminoid ingredient to assess for free curcuminoids, it is one of the first to assess it within the context of a pharmaceutically-aligned study protocol,” said Dr. Shavon Jackson-Michel, director of medical & scientific affairs for DolCas. “Dispersion was the principle mechanism enacted to overcome the challenge of curcuminoid absorption.”
     
    The Total Curcuminoid analysis of individual and composite curcuminoid analogues—specifically total curcumin, total demethoxycurcumin, total bis-demethoxycurcumin, and total curcuminoids—also was assessed in this novel study. The enhanced absorption (as determined by the difference in area under the curve) over the study duration yielded enhanced bioavailabilities of 49.5-, 43.5-, 46.8-, and 52.5-fold, when compared to the C-95 reference.
     
    “Curcuminoid conjugates are intestinal and liver metabolites and considered both inactive and intermediate in terms of their functionality. To be effective, they must be liberated, and while this process is simulated predictably outside the body, the literature suggests that inside the body the process is highly variable,” Jackson-Michel said. In fact, the natural process of deconjugation occurs under distinct conditions, inclusive of, but not limited to, an inflamed state or lowered pH, and in the presence of certain white blood cells, or in kidney tissues. This study sought to distinguish this unsettled concept of free vs. total curcuminoid analysis and its relationship to marketed claims that must be evaluated contextually.
     
    Tetrahydrocurcumin, is a metabolite of curcumin that, unlike the no-to-low activity curcuminoid-conjugates, expresses notable bioactivity, especially via its antioxidant and anticarcinogenic activities. Metabolized from curcumin in the liver and among the bacteria present in the gut, it is not naturally present in turmeric nor derived from basic extraction methods. As such, tetrahydrocurcumin was additionally assessed in this comparative bioavailability study. When compared to C-95, it was found in 31-fold higher quantities in the plasma with Curcugen.
     
    “Given C-95’s known resistance to absorption, equivalent concentrations of curcuminoids between it and Curcugen were assessed in accordance with acceptable pharmaceutical guidances for bioavailability study,” said DolCas CEO K. G. Rao.
     
    The study was designed to highlight and align with published best practices in curcuminoid pharmacokinetics, including minimum and matching dosing between test and reference products, analyte selections and proper definitions (i.e. free vs. total; analogues vs. metabolites). This was inclusive of preparation methods both with and without exogenous deconjugation steps; the need for internal standards use; neutral fasting and feeding conditions for subjects; and the use of plasma analysis instrumentation that offered the best accuracy and consistency.
     
    “Curcuminoid bioavailability also was assessed over a 24-hour period—a rarity among studies backing other bioavailability-enhanced curcumin formulations on the market,” Jackson-Michel said. “The 24-hour assessment, evidenced a primary peak of enhanced free curcumin at approximately 1.5-2 hours after intake; a moderately high second peak at about 8-hours post intake; and low but notably higher plasma levels over the duration of the 24 hours when compared to C-95.”
     
    Bioavailability enhancement above and beyond the 95% standardized curcuminoid extract is a function of formulation. Bioavailability-enhanced curcuminoid formulations have benefited from an array of applications, including natural, but non-turmeric native bioenhancers such as piperine, or emulsifiers such as lecithin-derived phospholipids. Also, binders and dispersants, such as cyclodextrin, or synthetic pharmaceutical actives like polysorbates have been used. Certain extra processes sometimes have been employed to benefit bioavailability enhancement, including nanoparticle manufacturing or the manipulation of native ratios of essential oils from turmeric to effect cell transport.
    Related Searches
    • Delivery & Dosage Technologies
    • Research
    • Herbs & Botanicals
    Related Knowledge Center
    • Research
    • Herbs & Botanicals
    • Delivery & Dosage Technologies
    Suggested For You
    Magnesium: An Essential Mineral with Many Forms and Functions Magnesium: An Essential Mineral with Many Forms and Functions
    Healthy, Clean Label Snacks and Nutrition Bars Help Fill Nutrient Gap Cleaved By Modern Lifestyles Healthy, Clean Label Snacks and Nutrition Bars Help Fill Nutrient Gap Cleaved By Modern Lifestyles
    All Eyes on Vision Health All Eyes on Vision Health
    Euromonitor Reveals Top 10 Global Consumer Trends Euromonitor Reveals Top 10 Global Consumer Trends
    FDA to Allow Vitamin D3 as Additive in Cereals, Grain-Based Bars FDA to Allow Vitamin D3 as Additive in Cereals, Grain-Based Bars
    Director of Research and Development Director of Research and Development
    Pharmactive Launches Kiwi Extract Designed to Improve Protein Absorption Pharmactive Launches Kiwi Extract Designed to Improve Protein Absorption
    Bell Flavors and Fragrances Predicts Consumer Trends and Behaviors for 2023 Bell Flavors and Fragrances Predicts Consumer Trends and Behaviors for 2023
    Sirio Pharma Acquires Best Formulations Sirio Pharma Acquires Best Formulations
    Milk Specialties Global Sold to Private Equity Firm Butterfly Milk Specialties Global Sold to Private Equity Firm Butterfly
    The Top 10 Articles of 2022 on NutraceuticalsWorld.com The Top 10 Articles of 2022 on NutraceuticalsWorld.com
    Top Trends in CBD: 2022 Market Year in Review Top Trends in CBD: 2022 Market Year in Review
    Bunge to Invest in New Protein Concentrate Facility in U.S. Bunge to Invest in New Protein Concentrate Facility in U.S.
    Arla Foods Ingredients Enters Supply Partnership with Milcobel Arla Foods Ingredients Enters Supply Partnership with Milcobel
    Novozymes and Chr. Hansen Enter Merger Agreement Novozymes and Chr. Hansen Enter Merger Agreement

    Related Features

    • Cognitive Function | Nutrition Bars & Snacks | Proteins, Peptides, Amino Acids
      Healthy, Clean Label Snacks and Nutrition Bars Help Fill Nutrient Gap Cleaved By Modern Lifestyles

      Healthy, Clean Label Snacks and Nutrition Bars Help Fill Nutrient Gap Cleaved By Modern Lifestyles

      Many consumers reach for snacks to help meet their health goals, but they want value and great flavor too.
      By Sean Moloughney, Editor 01.20.23

    • Cardiovascular Health | Cognitive Function | Delivery & Dosage Technologies | Dietary Supplements | Minerals
      Magnesium: An Essential Mineral with Many Forms and Functions

      Magnesium: An Essential Mineral with Many Forms and Functions

      This micronutrient has been gaining attention among consumers, and there’s much to consider in product formulation.
      By Mike Montemarano, Associate Editor 01.20.23

    • Antioxidants | Dietary Supplements | Eye Health | Healthcare Trends | Herbs & Botanicals
      All Eyes on Vision Health

      All Eyes on Vision Health

      Nutrition solutions are targeting unique challenges to eye health from the blue light of ubiquitous screens.
      By Sean Moloughney, Editor 01.20.23


    • Breaking News | Consumer Trends | Healthcare Trends | Industry & Market News | World Markets
      Euromonitor Reveals Top 10 Global Consumer Trends

      Euromonitor Reveals Top 10 Global Consumer Trends

      Several new factors will have a strong influence on purchasing behaviors as consumers cope with ongoing challenges, according to the company.
      01.19.23

    • Breaking News | Functional Foods & Beverages | Industry & Market News | Regulations | Vitamins
      FDA to Allow Vitamin D3 as Additive in Cereals, Grain-Based Bars

      FDA to Allow Vitamin D3 as Additive in Cereals, Grain-Based Bars

      The agency made an amendment to allow for the addition of D3 in specific food categories.
      01.18.23

    Loading, Please Wait..
    Trending
    • NOW Switches To Bottles Made From 100% Post-Consumer Recycled Resin
    • Shiitake Mushroom Extract Appears Helpful In HPV Infections
    • The Functional Chocolate Company Launches Painfree Chocolate
    Breaking News
    • Probiotics Supplementation Reduces Complications in Colorectal Cancer Patients
    • Vitamin D Supplementation Reduces Risk of Dynapenia
    • Sustained-Release Caffeine Ingredient Offers Mood, Performance Benefits
    • Multi-Strain Probiotic Improves Self-Reported Mood, Sleep, Serotonin Levels
    • CRN Highlights 'Supplement to Savings' Report for National Heart Month
    View Breaking News >
    CURRENT ISSUE

    Jan/Feb 2023

    • Healthy, Clean Label Snacks and Nutrition Bars Help Fill Nutrient Gap Cleaved By Modern Lifestyles
    • Magnesium: An Essential Mineral with Many Forms and Functions
    • Vitamin D: A Fixture of Supplementation and Fortification
    • Health Benefits of Vitamin K: A Contemporary Cornerstone of Heart and Bone Health
    • All Eyes on Vision Health
    • Researchers Develop New Global Estimate of Medicinal Plant Species and Conservation Status
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Probiotics Supplementation Reduces Complications in Colorectal Cancer Patients
    Vitamin D Supplementation Reduces Risk of Dynapenia
    Sustained-Release Caffeine Ingredient Offers Mood, Performance Benefits
    Coatings World

    Latest Breaking News From Coatings World

    Epoxytec Announces New Website Launch
    Paints and Coatings Market Worth $212B by 2026: MarketsandMarkets
    Axalta Releases Fourth Quarter and Full Year 2022 Results
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    BMP Medical Expands Sterling, Massachusetts Facility
    Abbott's Proclaim XR SCS OK'ed for Diabetic Neuropathy
    Environmental Sustainability Becoming Increasingly Important to Medtech Industry
    Contract Pharma

    Latest Breaking News From Contract Pharma

    Pasithea Signs CMC Development and Manufacturing Agreement
    Experic Expands Analytical Capabilities and Facilities
    List Labs Expands Manufacturing Capacity
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Haircare Brand Uncle Funky’s Daughter Announces Retail Expansion
    TRESemmé Introduces New Pro Infusion Collection
    Walgreens Boots Alliance Shares 2022 ESG Report
    Happi

    Latest Breaking News From Happi

    KimChi Beauty Launches Spinning Hearts Love 02 Ahead of Valentine’s Day
    Dark & Lovely Names Actress Meagan Good Brand Ambassador
    Natural Household Care Company Tru Earth Adds Dishwasher Detergent Tablets
    Ink World

    Latest Breaking News From Ink World

    Xerox Releases 4Q, Full-Year 2022 Results
    Electronics For Imaging Names Frank Pennisi as CEO
    Fiery to Separate from EFI, Remain Wholly-Owned by Siris
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    EFI appoints Frank Pennisi CEO, Fiery now an independent business
    Bobst boosts senior sales team with Keith Nagle
    Penmar Industries adds Screen Truepress Jet L350UV SAI digital press
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Essity’s Sales Grow
    Thinx to Pay up to $5 million to Settle Class Action Suit
    Typar Highlighting New Building Innovations
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    Orthofix Launches the Mariner Deformity System
    Tyber Medical Hires 2 New Execs
    Miach Ortho Raises $40M in Series B Funding
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Smart Devices with Privacy Focus Have More Consumer Appeal
    Siman Group Partners with SML to Unlock Full Retail Potential with RFID
    Brewer Science Presents Optics Integration Solutions at SPIE Photonics West

    Copyright © 2023 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login