07.12.21
Nicotinamide Mononucleotide (NMN), a nutraceutical ingredient shown to increase the production of NAD+ in the human body, was evidenced in a recent clinical trial to enhance aerobic capacity achieved through exercise training, compared to just training alone, in amateur runners.
Forty eight young and middle-aged recreationally-trained runners were enrolled in the study, which involved 5-6 training sessions each week, and combined with either an NMN supplement or a placebo, dependent on whether the runner was in a control or one of three experimental groups. Each group included ten male and two female participants, and either took a placebo, a low dose (300mg/day), medium dose (600 mg/day) or a high dose (1,200 mg/day) of NMN.
“Nicotinamide adenine dinucleotide (NAD+, the production of which is enhanced by NMN) is pivotal to physiological processes, not only as the coenzyme of cellular oxidation – reduction reactions but also for the activation of NAD+ consuming enzymes […] NAD+ participates in more than 50% of all physiological processes, including mitochondrial biogenesis, cardiovascular protection, neuroprotection, oxidative stress, DNA damage repair, stem cell rejuvenation, and inflammation,” the authors of the study said.
In the study, all of the participants were instructed not to change their habitual diet and daily living routines, and refrained from using caffeine during the study, with daily NMN supplementation lasting six weeks, and doses taken prior to training.
By the end of the study, it was found that while NMN supplementation combined with exercise didn’t achieve significant differences compared to placebo in the areas of body composition or BMI, there was a significant increase in ventilatory threshold (a measurement of how efficiently the body circulates oxygen), signifying possible improvements to endurance achieved by NMN supplementation.
The authors of the study noted other key findings, such as that the health benefit observed in the study was dose-dependent, and that the improvement was muscle- and not cardiac-related.
“NMN as an adjunct treatment may help to improve performance during exercise training,” the authors of the study concluded. “Exercise training combining with NMN supplementation may be a novel and practical strategy to increase endurance performance of athletes.”
Forty eight young and middle-aged recreationally-trained runners were enrolled in the study, which involved 5-6 training sessions each week, and combined with either an NMN supplement or a placebo, dependent on whether the runner was in a control or one of three experimental groups. Each group included ten male and two female participants, and either took a placebo, a low dose (300mg/day), medium dose (600 mg/day) or a high dose (1,200 mg/day) of NMN.
“Nicotinamide adenine dinucleotide (NAD+, the production of which is enhanced by NMN) is pivotal to physiological processes, not only as the coenzyme of cellular oxidation – reduction reactions but also for the activation of NAD+ consuming enzymes […] NAD+ participates in more than 50% of all physiological processes, including mitochondrial biogenesis, cardiovascular protection, neuroprotection, oxidative stress, DNA damage repair, stem cell rejuvenation, and inflammation,” the authors of the study said.
In the study, all of the participants were instructed not to change their habitual diet and daily living routines, and refrained from using caffeine during the study, with daily NMN supplementation lasting six weeks, and doses taken prior to training.
By the end of the study, it was found that while NMN supplementation combined with exercise didn’t achieve significant differences compared to placebo in the areas of body composition or BMI, there was a significant increase in ventilatory threshold (a measurement of how efficiently the body circulates oxygen), signifying possible improvements to endurance achieved by NMN supplementation.
The authors of the study noted other key findings, such as that the health benefit observed in the study was dose-dependent, and that the improvement was muscle- and not cardiac-related.
“NMN as an adjunct treatment may help to improve performance during exercise training,” the authors of the study concluded. “Exercise training combining with NMN supplementation may be a novel and practical strategy to increase endurance performance of athletes.”
