• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Nutraceuticals for Men: Muscle Health and Performance Nutrition

    Aging in Place: Healthy Lifestyles Supplement Science-Based Solutions

    Getting an Edge in Esports: Meeting the Health Needs of Competitive Gamers

    Beyond CBD: Cannabis Compounds Warrant Recognition and More Research

    Leveling Out the Energy Segment for Mainstream, and Rethinking Caffeine
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    Thorne Relaunches Gut Health Test with Microbiome Wipe

    Alkemist Labs Announces Alkemist Assured Seal and Next Generation Transparency Reports

    GC Rieber Foundations Expand Philanthropic Efforts

    Danone Celebrates 10th anniversary of Grant Program for Probiotics Research

    Stratum Nutrition’s Patent Portfolio Grows to Europe and Canada
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    GC Rieber Foundations Expand Philanthropic Efforts

    Danone Celebrates 10th anniversary of Grant Program for Probiotics Research

    Botanical Ingredient MorActive Evidenced to Relieve Back Discomfort

    Cargill’s Stevia Sustainability Program Benchmarked by FSA

    GOED Creates Infographic Highlighting Omega-3 Health Claims Approved in Europe
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    Thorne Relaunches Gut Health Test with Microbiome Wipe

    Alkemist Labs Announces Alkemist Assured Seal and Next Generation Transparency Reports

    GC Rieber Foundations Expand Philanthropic Efforts

    Danone Celebrates 10th anniversary of Grant Program for Probiotics Research

    Stratum Nutrition’s Patent Portfolio Grows to Europe and Canada
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    Thorne Relaunches Gut Health Test with Microbiome Wipe

    Danone Celebrates 10th anniversary of Grant Program for Probiotics Research

    Beyond Raw Launches Concept X Pre-Workout Line

    Botanical Ingredient MorActive Evidenced to Relieve Back Discomfort

    Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    KLK OLEO

    Aiya America, Inc. (Aiya Matcha)

    Botanic Healthcare LLC

    Atlantia Clinical Trials

    Nutrition21, LLC
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    KLK OLEO

    Aiya America, Inc. (Aiya Matcha)

    Botanic Healthcare LLC

    Atlantia Clinical Trials

    Nutrition21, LLC
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Breaking News

    Review of Overlapping Vitamin A Studies Highlights Concerns About Over-Supplementation

    Clinical evidence suggests reconsidering a tolerable upper limit for vitamin A based on liver health concerns.

    Review of Overlapping Vitamin A Studies Highlights Concerns About Over-Supplementation
    Related CONTENT
    • FDA Issues Draft Guidance on NDI Enforcement Discretion
    • GOED Creates Infographic Highlighting Omega-3 Health Claims Approved in Europe
    • Jordan Process Receives Nutrasource ICAP Certification for CBD
    • Draft Senate Bill to Reauthorize FDA User Fees Includes Dietary Supplement Listing Provision
    • FDA Warns About Steroids or Steroid-Like Substances in Bodybuilding Products
    11.20.20
    According to a study and corresponding review recently published in Oxford University’s Journal of Nutrition, researchers should be concerned about liver health issues associated with excessive intake of vitamin A and provitamin A carotenoids, such as observed increases in liver retinol concentrations.
     
    In an in vitro study published this month, researchers sought to evaluate any complications that might arise due to over-supplementation with vitamin A, speaking to concerns about overlapping clinical trials in humans during which intake well exceeds daily recommendations. This is especially prevalent in studies evaluating biofortification in areas where vitamin A deficiency is prevalent. Globally, approximately 2.3% of all deaths among children below the age of 5 years are attributable to vitamin A deficiency.
     
    The researchers simulated two studies, both of which involved vitamin A interventions, to determine the effects of biofortified maize and carrot consumption combined, and found liver complications in the Mongolian gerbils used in the in vitro study. The combined bio-fortified foods resulted in the gerbils taking in 100%-200% of the estimated vitamin A content that they needed, in order to simulate scenarios in which children consumed high amounts of vitamin A in order to reflect overlapping clinical trials. High liver stores of vitamin A (hypervitaminosis) were observed at values formerly referred to as toxicity, the authors wrote.
     
    “These studies support the importance of monitoring vitamin A (VA) status in populations exposed to food fortification with preformed VA as a public health measure to combat vitamin A deficiency, and of considering the likelihood of inducing excessive VA stores,” the authors concluded. They pointed to a corresponding trial showing that there is already human impact associated with overlapping food fortification programs causing a sizeable portion of children to experience hypervitaminosis A.
     
    “Currently, retinol isotope dilution is the only indicator that can evaluate VA excess before toxicity manifests. This methodology was recently used to evaluate a cohort of South African preschool children who were exposed to high dietary VA intake due to habitual liver consumption and government mandated VA supplementation and fortification of maize meal and wheat flour. Before the next round of mandated VA supplementation, 65.3% of the cohort had hypervitaminosis A, reinforcing the importance of accurate VA biomarkers to inform policies.”
     
    While vitamin A has generally been regarded as safe in research settings to date, an accompanying review of the study posed a question as to whether the definition of a tolerable upper intake level should be raised to include the contributions of provitamin A carotenoids. At this point, however, the evidence for setting the cutoff for hypervitaminosis A is limited, the review said.
     
    “In conclusion, more data are needed to accurately determine cutoff values for biomarkers for assessing excessive VA status to enable a comprehensive evaluation of the safety of current ongoing and planned future VA interventions and programs,” the authors concluded.
    Related Searches
    • Medical Nutrition
    • Functional Foods & Beverages
    • Vitamins
    • Dietary Supplements
    Related Knowledge Center
    • Dietary Supplements
    • Research
    • Medical Nutrition
    Suggested For You
    FDA Issues Draft Guidance on NDI Enforcement Discretion FDA Issues Draft Guidance on NDI Enforcement Discretion
    GOED Creates Infographic Highlighting Omega-3 Health Claims Approved in Europe GOED Creates Infographic Highlighting Omega-3 Health Claims Approved in Europe
    Jordan Process Receives Nutrasource ICAP Certification for CBD Jordan Process Receives Nutrasource ICAP Certification for CBD
    Draft Senate Bill to Reauthorize FDA User Fees Includes Dietary Supplement Listing Provision Draft Senate Bill to Reauthorize FDA User Fees Includes Dietary Supplement Listing Provision
    FDA Warns About Steroids or Steroid-Like Substances in Bodybuilding Products  FDA Warns About Steroids or Steroid-Like Substances in Bodybuilding Products
    Experts Debate Role of Supplements in Improving Public Health in EU Experts Debate Role of Supplements in Improving Public Health in EU
    NSF and SCNM’s School of Nutrition Collaborate on Master of Science Program NSF and SCNM’s School of Nutrition Collaborate on Master of Science Program
    Indena Spotlights ‘Fabulous Four’ Ingredients Indena Spotlights ‘Fabulous Four’ Ingredients
    Third-Party Certifications Support Consumer Demand for Quality and Transparency Third-Party Certifications Support Consumer Demand for Quality and Transparency
    Open Book Extracts Completes Phase 1 of Toxicology, Safety Assessment for Cannabinoid Ingredients Open Book Extracts Completes Phase 1 of Toxicology, Safety Assessment for Cannabinoid Ingredients
    A Postbiotic with Unmatched Clinical Research A Postbiotic with Unmatched Clinical Research
    Podcast: Michael McGuffin Discusses Dietary Supplement Regulation and Mandatory Product Listing Bill Podcast: Michael McGuffin Discusses Dietary Supplement Regulation and Mandatory Product Listing Bill
    FDA Issues Warning Letters to Companies Selling CBD, Delta-8 THC Products FDA Issues Warning Letters to Companies Selling CBD, Delta-8 THC Products
    James Roza of Layn Natural Ingredients: Driving the Science and Botanical Innovation James Roza of Layn Natural Ingredients: Driving the Science and Botanical Innovation
    Environmental, Social and Governance in the Cannabis Industry: A Perfect Storm is Brewing Environmental, Social and Governance in the Cannabis Industry: A Perfect Storm is Brewing

    Related Content

    • Dietary Supplements | Regulations
      FDA Issues Draft Guidance on NDI Enforcement Discretion

      FDA Issues Draft Guidance on NDI Enforcement Discretion

      Amnesty for late NDI notifications is intended to encourage manufacturers and distributors to correct past failures while collecting safety data, FDA said.
      By Sean Moloughney, Editor 05.20.22

    • Breaking News | Industry & Market News | Omega-3s | World Markets
      GOED Creates Infographic Highlighting Omega-3 Health Claims Approved in Europe

      GOED Creates Infographic Highlighting Omega-3 Health Claims Approved in Europe

      The European Food Safety Authority has approved nine health claims on EPA and DHA.
      05.20.22

    • Breaking News | Certifications, Approvals & Patents | Herbs & Botanicals | Quality & Safety | Testing
      Jordan Process Receives Nutrasource ICAP Certification for CBD

      Jordan Process Receives Nutrasource ICAP Certification for CBD

      The company was the first raw material provider to join the certification program.
      05.18.22


    • Dietary Supplements | Regulations
      Draft Senate Bill to Reauthorize FDA User Fees Includes Dietary Supplement Listing Provision

      Draft Senate Bill to Reauthorize FDA User Fees Includes Dietary Supplement Listing Provision

      HELP Committee released discussion draft that includes language similar to Senate Bill 4090 introduced last month by Senators Durbin and Braun.
      By Sean Moloughney, Editor 05.18.22

    • Breaking News | Dietary Supplements | Industry & Market News | Quality & Safety | Sports Nutrition
      FDA Warns About Steroids or Steroid-Like Substances in Bodybuilding Products

      FDA Warns About Steroids or Steroid-Like Substances in Bodybuilding Products

      According to the agency, these products are promoted as hormone products or alternatives to anabolic steroids.
      05.18.22

      Trending
      • Leaven Essential To Launch Branded Botanical Extracts To Global Markets | Nutraceuticals World
      • Oregon Files Lawsuit Against GNC | Nutraceuticals World
      • Vitamin D3, Omega-3s, Exercise May Cumulatively Reduce Cancer Risk In Older Adults | Nutraceuticals World
      • Coca-Cola To Phase Out Honest Tea Brand By Year’s End, Citing Supply Chain Challenges | Nutraceuticals World
      Breaking News
      • Thorne Relaunches Gut Health Test with Microbiome Wipe
      • Alkemist Labs Announces Alkemist Assured Seal and Next Generation Transparency Reports
      • GC Rieber Foundations Expand Philanthropic Efforts
      • Danone Celebrates 10th anniversary of Grant Program for Probiotics Research
      • Stratum Nutrition’s Patent Portfolio Grows to Europe and Canada
      View Breaking News >
      CURRENT ISSUE

      May 2022

      • Aging in Place: Lifestyle Supplements Science-Based Solutions
      • Getting an Edge in Esports: Meeting Health & Nutrition Needs
      • Nutraceuticals for Men: Muscle Health and Performance Nutrition

      Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
      You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

      • About Us
      • Privacy Policy
      • Terms And Conditions
      • Contact Us

      follow us

      Subscribe
      Nutraceuticals World

      Latest Breaking News From Nutraceuticals World

      Thorne Relaunches Gut Health Test with Microbiome Wipe
      Alkemist Labs Announces Alkemist Assured Seal and Next Generation Transparency Reports
      GC Rieber Foundations Expand Philanthropic Efforts
      Coatings World

      Latest Breaking News From Coatings World

      PPG Hosts The Future of Coatings' Technology Innovation Day in Amsterdam
      Azelis Expands Presence in India with Acquisition of Chemo India and Unipharm Laboratories
      Teknos Publishes Sustainability Report
      Medical Product Outsourcing

      Latest Breaking News From Medical Product Outsourcing

      Hologic Gains CE Mark for 2 Molecular Assays for Transplant Patients
      Vector Remote Care Rolls Out New Cardiac Care Software Platform
      FDA OKs Apyx Medical's Renuvion for Dermal Resurfacing
      Contract Pharma

      Latest Breaking News From Contract Pharma

      Mirum Pharmaceuticals Acquires San Diego-based Satiogen
      Catalyst Biosciences Sells Complement Portfolio to Vertex Pharmaceuticals
      Insmed Appoints Drayton Wise as Chief Commercial Officer
      Beauty Packaging

      Latest Breaking News From Beauty Packaging

      La Roche-Posay Launches Matte Moisturizer for Oily Skin
      3 Amorepacific Employees Stole $2.3 Million
      L'Oreal CEO Nicolas Hieronimus On Sustainability Initiatives
      Happi

      Latest Breaking News From Happi

      Thayers Natural Remedies Celebrates 175 Years with Social Campaign
      Former Model Shirley Powell’s Indie Beauty Brand LaJeanell Comprises Gender Inclusive Skincare and Makeup
      L’Oréal's New UVMune 400 Sun Filtering Technology Protects Skin From Ultra-Long UVA Rays
      Ink World

      Latest Breaking News From Ink World

      CEMATEX Introduces Online Business Platform to Connect Global Textile Community
      PICO Chemical Celebrates 46 Years
      Epson Introduces Two New SurePress Digital Label Presses
      Label & Narrow Web

      Latest Breaking News From Label & Narrow Web

      AWA to host 22nd Global Release Liner Industry Conference & Exhibition
      Domino assists Grace Label with supply chain disruptions
      Rotocon wins AI Business Excellence Award
      Nonwovens Industry

      Latest Breaking News From Nonwovens Industry

      Rael Raises $35M in Series B Funding
      Schobertechnologies Offers Rotary Web-fed Converting Solutions
      Thorne Relaunches Gut Health Test with Microbiome Wipe
      Orthopedic Design & Technology

      Latest Breaking News From Orthopedic Design & Technology

      Emovi, Geneva Foundation Providing Knee Treatment Tech to U.S. Army
      Study Confirms Knee Shapes are Highly Individualized
      Stryker Launches EasyFuse Dynamic Compression for Foot & Ankle
      Printed Electronics Now

      Latest Breaking News From Printed Electronics Now

      ARPA-E Funding Drives Innovation, Industry Partnerships at NREL
      InnovationLab Acquires Flexible Printed Battery Technology from Evonik
      Canatu Receives IATF 16949:2016 Certification

      Copyright © 2022 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

      AD BLOCKER DETECTED

      Our website is made possible by displaying online advertisements to our visitors.
      Please consider supporting us by disabling your ad blocker.


      FREE SUBSCRIPTION Already a subscriber? Login