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    Breaking News

    Study Demonstrates Benefits of Natreon's AyuFlex for Joint Health

    Study found AyuFlex could significantly improve joint discomfort.

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    05.31.16
    Natreon's AyuFlex, a clinically studied and standardized aqueous extract of Terminalia chebula, significantly improves joint discomfort according to a human clinical study just published in The Asian Journal of Pharmaceutical and Clinical Research. AyuFlex is a GRAS-affirmed and patented ingredient for joint health and pain relief.
     
    Osteoarthritis (OA) is one of the most common forms of arthritis and is the leading cause of disability in American adults. It is a chronic condition that is known to affect weight-bearing and other moveable joints. In the U.S., an estimated 27 million people older than 25 years have clinical OA. Traditionally, NSAIDs have been the mainstay of treatment for acute and chronic pain conditions, including osteoarthritis. However, the risks of gastrointestinal toxicity and renal impairment have led to the search for alternative analgesics with fewer adverse effects, such as Terminalia chebula.
     
    In this randomized, double-blind, placebo controlled study, a total of 100 healthy human volunteers suffering from joint discomfort for at least 6 months were randomized into five treatment groups: AyuFlex 500 mg twice daily, AyuFlex 500 mg twice daily + Proprietary Chromium Complex (PCC) 400 μg once daily, PCC 400 μg once daily alone, placebo, and AyuFlex 250 mg twice daily for 12 weeks. Proprietary Chromium Complex (PCC) was added to the study because in a previous clinical study at Murray State University in Kentucky, this compound significantly improved joint discomfort in dogs, and its efficacy in humans needed to be evaluated. Assessment of symptoms of knee joint pain and discomfort was done by modified Western Ontario and McMaster Universities Arthritis Index (mWOMAC) and knee swelling index (KSI). Visual analog scale (VAS) was also used for subjective assessment of pain, stiffness, and disability.

    Results from this study showed that treatment with AyuFlex 500 mg twice daily for 12 weeks resulted in significant improvements in mWOMAC scores compared to placebo (36% reduction vs. 4.52% in placebo; p < 0.001), knee swelling index ( p < 0.001 vs. placebo), and VAS pain, stiffness, and disability (p < 0.001 for all categories vs. placebo). The therapeutic benefit was evident in as little as 4 weeks. In addition, the number of rescue medications (acetaminophen) used by subjects was the least in the AyuFlex 500 mg twice daily group. This supports the analgesic efficacy of AyuFlex. The response seems to have a linear relationship with dose. In regards to safety, all the study medications were well tolerated and no serious adverse events were reported. No subjects dropped out of the study and all laboratory parameters were within normal limits at the end of the study. Due to its positive safety profile and ability to improve joint discomfort, Natreon suggested AyuFlex might be a good choice for acute or chronic painful ailments, especially in patients who may be at higher risk for gastrointestinal or renal complications.
     
    For more information: http://natreoninc.com
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