Unigen will introduce two new botanical ingredients at this year’s Natural Products Expo West in Anaheim, CA. The new ingredients in Unigen’s botanical portfolio are Attenutin for respiratory health, and Symetrian for immune support.
 
“We are very excited to expand our profile at this time with these two ingredients,” Dr. Qi Jia, Unigen CEO and CEO, said. “Since early 2020, Unigen shifted its R&D focus to immune and respiratory health. We evaluated hundreds of bioflavonoids in our PhytoLogix library and historic data on maintaining a healthy level of an alarmin protein called HMGB1 that is proven to support and protect the immune function of the respiratory system.”
 
The final composition of Attenutin contains two bioflavonoids clinically supported to modulate both innate and active immune function, while supporting the production of the antibodies IgA and IgG and a healthy level of cytokines. The product is derived from the roots of Scutellaria baicalensis and the heartwood of Acacia catechu. The ingredient is evidenced to increase levels of glutathione peroxidase, indicating antioxidant activity, and is suitable for short-term use such as with vitamin C and zinc on a seasonal basis.
 
Unigen also tested many polysaccharides in combinations with different polyphenols, which led to successful clinical trials of an aloe polysaccharide-based composition called Symetrian, which is standardized to support immune homeostasis. It has been shown in clinical studies to promote the production of circulating TCRγδ+ Gamma delta T cells, suggesting its heightened immune surveillance at portals of entry.  Derived from Aloe vera leaf gel powder, Poria cocos sclerotium extract, and rosemary leaf extracts, Symetrian has been clinically shown to increase anti-oxidation capacity through elevated levels of glutathione peroxidase.  
 
In the second clinical trial of rapid immune modulation, a single oral dose showed progressive activation of lymphocytes (NKT cells, NK cells; cytotoxic T cells, γδ­‑T cells) over a three-hour period in the blood where the percent changes in activation were found statistically significant against placebo. Symetrian is suitable as a long-term dietary supplement year-round for all populations, according to Unigen.