11.01.03
Indication: Bone loss in postmenopausal women
Source: J Clin Endocrinol Metabolism, 2003;88:4740-4747.
Research: Researchers preformed a double-blind, randomized, placebo-controlled study for one year on 203 Chinese postmenopausal women between the ages of 48-62 years old. The women received either one of two isoflavone dosages (40 or 80 mg aglycones daily) or a placebo (corn starch). In addition, all women were given 500 mg of calcium and 125 IU of vitamin D3. Bone mineral density (BMD) and bone mineral concentration (BMC) of the whole body, lumbar spine and hip were measured at baseline and after one year of treatment.
Results: Analysis showed that women taking the high-dose isoflavone treatment (80 mg) had a significant favorable change rate in BMC at total hip and the trochanter and intertrochanter, compared to placebo. This effect was independent of calcium and vitamin D3. An increase of 1 mg of isoflavones per day was associated with a yearly increase of .018-.028% of BMC at these bone sites. The researchers concluded that isoflavones have a mild, but statistically significant effect on the maintenance of BMC in the hip in postmenopausal women with low initial bone mass.
Source: J Clin Endocrinol Metabolism, 2003;88:4740-4747.
Research: Researchers preformed a double-blind, randomized, placebo-controlled study for one year on 203 Chinese postmenopausal women between the ages of 48-62 years old. The women received either one of two isoflavone dosages (40 or 80 mg aglycones daily) or a placebo (corn starch). In addition, all women were given 500 mg of calcium and 125 IU of vitamin D3. Bone mineral density (BMD) and bone mineral concentration (BMC) of the whole body, lumbar spine and hip were measured at baseline and after one year of treatment.
Results: Analysis showed that women taking the high-dose isoflavone treatment (80 mg) had a significant favorable change rate in BMC at total hip and the trochanter and intertrochanter, compared to placebo. This effect was independent of calcium and vitamin D3. An increase of 1 mg of isoflavones per day was associated with a yearly increase of .018-.028% of BMC at these bone sites. The researchers concluded that isoflavones have a mild, but statistically significant effect on the maintenance of BMC in the hip in postmenopausal women with low initial bone mass.