01.01.03
Indication: Heart disease
Source: JAMA November, 2002;288:2432-2440.
Research: The Women’s Angiographic Vitamin and Estrogen (WAVE) trial studied 423 women at seven clinical centers in the U.S. and Canada. The women were randomly assigned to one of four treatment groups: the HRT (hormone replacement therapy) group took either estrogen (Premarin) or estrogen plus progestin (Prempro) if they had not had a hysterectomy; a second group took 400 IU of vitamin E plus 500 mg of vitamin C, twice a day, or a placebo; some women took both HRT and the vitamins and a fourth group of women took only placebos. Angiograms were performed when women entered the study and at study exit approximately three years later.
Results: Measurements suggested that artery narrowing was the same or slightly worse for women taking HRT compared with women taking a placebo, and for women taking the antioxidant vitamins compared with women taking the placebo. Rates of death, nonfatal heart attack and stroke were also higher among women taking HRT and vitamins than women taking placebos.
Source: JAMA November, 2002;288:2432-2440.
Research: The Women’s Angiographic Vitamin and Estrogen (WAVE) trial studied 423 women at seven clinical centers in the U.S. and Canada. The women were randomly assigned to one of four treatment groups: the HRT (hormone replacement therapy) group took either estrogen (Premarin) or estrogen plus progestin (Prempro) if they had not had a hysterectomy; a second group took 400 IU of vitamin E plus 500 mg of vitamin C, twice a day, or a placebo; some women took both HRT and the vitamins and a fourth group of women took only placebos. Angiograms were performed when women entered the study and at study exit approximately three years later.
Results: Measurements suggested that artery narrowing was the same or slightly worse for women taking HRT compared with women taking a placebo, and for women taking the antioxidant vitamins compared with women taking the placebo. Rates of death, nonfatal heart attack and stroke were also higher among women taking HRT and vitamins than women taking placebos.