• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Nutraceuticals for Men: Muscle Health and Performance Nutrition

    Aging in Place: Healthy Lifestyles Supplement Science-Based Solutions

    Getting an Edge in Esports: Meeting the Health Needs of Competitive Gamers

    Beyond CBD: Cannabis Compounds Warrant Recognition and More Research

    Leveling Out the Energy Segment for Mainstream, and Rethinking Caffeine
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board

    Expert Consensus Statement: Diet is Best Primary Intervention to Achieve Diabetes Remission

    Choline Alone May Improve Maternal DHA Status During Pregnancy

    Cranberry Consumption Linked to Memory and Neurological Function Improvements

    Bilberon Bilberry Extract Receives U.S. Patent For Eye Strain, Neck/Shoulder Pain
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board

    Choline Alone May Improve Maternal DHA Status During Pregnancy

    Cranberry Consumption Linked to Memory and Neurological Function Improvements

    Bilberon Bilberry Extract Receives U.S. Patent For Eye Strain, Neck/Shoulder Pain

    Jordan Process Receives Nutrasource ICAP Certification for CBD
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board

    Expert Consensus Statement: Diet is Best Primary Intervention to Achieve Diabetes Remission

    Choline Alone May Improve Maternal DHA Status During Pregnancy

    Cranberry Consumption Linked to Memory and Neurological Function Improvements

    Bilberon Bilberry Extract Receives U.S. Patent For Eye Strain, Neck/Shoulder Pain
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board

    Expert Consensus Statement: Diet is Best Primary Intervention to Achieve Diabetes Remission

    Choline Alone May Improve Maternal DHA Status During Pregnancy

    Cranberry Consumption Linked to Memory and Neurological Function Improvements

    Bilberon Bilberry Extract Receives U.S. Patent For Eye Strain, Neck/Shoulder Pain
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    Applied Food Sciences, Inc.

    KLK OLEO

    Gencor

    Xsto Solutions

    Ecuadorian Rainforest
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    Applied Food Sciences, Inc.

    KLK OLEO

    Gencor

    Xsto Solutions

    Ecuadorian Rainforest
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Breaking News

    Lower Omega-3 Levels Associated with Bipolar Disorder

    Researchers suggest testing interventions that increase omega-3 and decrease omega-6 PUFA intake.

    Related CONTENT
    • What to Expect Next Week at Vitafoods Europe 2022
    • Aging in Place: Healthy Lifestyles Supplement Science-Based Solutions
    • Nutrilead’s BeniCaros Ingredient Receives FDA Green Light
    • NGS Launches Healthy Heights KidzProtein Nutritional Shakes
    • Hibiscus and Lemon Balm Complex May Offer Gut Health Benefits
    01.05.16
    Omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) are molecular modulators of neurotransmission and inflammation. Researchers hypothesized that plasma concentrations of omega-3 PUFAs would be lower and those of omega-6 PUFAs higher in subjects with bipolar disorder (BD) compared to healthy controls (HCs), and would correlate with symptom severity in subjects with BD, and that effective treatment would correlate with increased omega-3 but lower omega-6 PUFA levels. Additionally, they explored clinical correlations and group differences in plasma levels of saturated and monounsaturated fatty acids. Their study was published in the journal Bipolar Disorders.

    This observational, parallel group study compared biomarkers between HCs (n=31) and symptomatic subjects with BD (n=27) when ill and after symptomatic recovery (follow-up). Plasma concentrations of five PUFAs [linoleic acid (LA), arachidonic acid (AA), alpha-linolenic acid (ALA), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)], two saturated fatty acids (palmitic acid and stearic acid) and two monounsaturated fatty acids (palmitoleic acid and oleic acid) were measured in esterified (E) and unesterified (UE) forms.

    Calculated ratios included UE:E for the five PUFAs, ratios of omega-3 PUFAs (DHA:ALA, EPA:ALA and EPA:DHA), and the ratio of omega-6:omega-3 AA:EPA.

    UE EPA was lower in subjects with BD than in HCs, with a large effect size (Cohen’s d=0.86, p < 0.002); however, it was not statistically significant after correction for multiple comparisons. No statistically significant difference was seen in any plasma PUFA concentration between the BD and HC groups after Bonferroni correction for 40 comparisons, at p < 0.001. Neither depressive severity nor mania severity was correlated significantly with any PUFA concentration. Exploratory comparison showed lower UE:E EPA in the BD than the HC group (p < 0.0001). At follow-up in the BD group, UE, E DHA:ALA, and UE EPA:ALA were decreased (p < 0.002). Exploratory correlations of clinical variables revealed that mania severity and suicidality were positively correlated with UE:E EPA ratio, and that several plasma levels and ratios correlated with panic disorder and psychosis. Depressive severity was not correlated with any ratio. No plasma fatty acid level or ratio correlated with self-reported omega-3 PUFA intake or use of medication by class.

    A large effect size of reduced UE EPA, and a lower plasma UE:E concentration ratio of EPA in the symptomatic BD state may be important factors in vulnerability to a mood state, according to researchers. Altered omega-3 PUFA ratios could indicate changes in PUFA metabolism concurrent with symptom improvement. The findings were consistent with preclinical and postmortem data and suggested testing interventions that increase omega-3 and decrease omega-6 dietary PUFA intake.
    Related Searches
    • Inflammation
    • EPA
    • recovery
    • Omega-6
    Related Knowledge Center
    • Research
    • Fatty Acids
    • Inflammation
    Suggested For You
    What to Expect Next Week at Vitafoods Europe 2022 What to Expect Next Week at Vitafoods Europe 2022
    Aging in Place: Healthy Lifestyles Supplement Science-Based Solutions Aging in Place: Healthy Lifestyles Supplement Science-Based Solutions
    Nutrilead’s BeniCaros Ingredient Receives FDA Green Light  Nutrilead’s BeniCaros Ingredient Receives FDA Green Light
    NGS Launches Healthy Heights KidzProtein Nutritional Shakes NGS Launches Healthy Heights KidzProtein Nutritional Shakes
    Hibiscus and Lemon Balm Complex May Offer Gut Health Benefits Hibiscus and Lemon Balm Complex May Offer Gut Health Benefits
    Nuseed’s Omega-3 Canola Ingredients Succeed FDA Review For Human, Animal Safety Nuseed’s Omega-3 Canola Ingredients Succeed FDA Review For Human, Animal Safety
    Beyond CBD: Cannabis Compounds Warrant Recognition and More Research Beyond CBD: Cannabis Compounds Warrant Recognition and More Research
    Natural Products Expo West Returns: Product Spotlight Natural Products Expo West Returns: Product Spotlight
    The Role of Gut Health in Children The Role of Gut Health in Children's Immune, Cognitive Function
    Clinical Study Finds Plant-Based Omega-3 Ingredient Efficacious Clinical Study Finds Plant-Based Omega-3 Ingredient Efficacious
    Stem & Root, Nutrileads Launch Daily Immunity Supplement Stem & Root, Nutrileads Launch Daily Immunity Supplement
    Krill Oil Increases Omega-3 Index, Plasma Choline, and Antioxidant Capacity, Study Finds Krill Oil Increases Omega-3 Index, Plasma Choline, and Antioxidant Capacity, Study Finds
    Experts Discuss Emerging Omega-3s Research at GOED Exchange Experts Discuss Emerging Omega-3s Research at GOED Exchange
    Next-Gen Sports Nutrition: Performance and Personalization Next-Gen Sports Nutrition: Performance and Personalization
    FARI Expands Team of Scientists  FARI Expands Team of Scientists

    Related Content

    • What to Expect Next Week at Vitafoods Europe 2022

      What to Expect Next Week at Vitafoods Europe 2022

      Organizers expect a participant count of 25,000, along with a number of key industry trends.
      05.03.22

    • Bone & Joint Health | Cancer Risk | Cardiovascular Health | Consumer Trends | Dietary Supplements | Healthcare Trends | Healthy Aging | Mood Health & Sleep | Sports Nutrition
      Aging in Place: Healthy Lifestyles Supplement Science-Based Solutions

      Aging in Place: Healthy Lifestyles Supplement Science-Based Solutions

      In all aspects of health, prevention pays off.
      By Sean Moloughney, Editor 05.03.22

    • Breaking News | Herbs & Botanicals | Immune Function | Natural/Organic | Quality & Safety | Supplier News
      Nutrilead’s BeniCaros Ingredient Receives FDA Green Light

      Nutrilead’s BeniCaros Ingredient Receives FDA Green Light

      The company received what’s known as a ‘No Questions’ statement from the agency on its GRAS declaration.
      04.28.22


    • Breaking News | Functional Foods & Beverages | Infant & Children's Health | Products
      NGS Launches Healthy Heights KidzProtein Nutritional Shakes

      NGS Launches Healthy Heights KidzProtein Nutritional Shakes

      The shakes include a dairy and vegan variety to support children’s developmental needs.
      04.25.22

    • Breaking News | Dietary Supplements | Digestive Health | Herbs & Botanicals | Research | Research News | Weight Management/Weight Loss
      Hibiscus and Lemon Balm Complex May Offer Gut Health Benefits

      Hibiscus and Lemon Balm Complex May Offer Gut Health Benefits

      The formula may improve populations of beneficial Bifidobacterium, Blautia, and Faecali-bacterium, along with other minor genera.
      04.18.22

      Breaking News
      • Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board
      • Expert Consensus Statement: Diet is Best Primary Intervention to Achieve Diabetes Remission
      • Choline Alone May Improve Maternal DHA Status During Pregnancy
      • Cranberry Consumption Linked to Memory and Neurological Function Improvements
      • Bilberon Bilberry Extract Receives U.S. Patent For Eye Strain, Neck/Shoulder Pain
      View Breaking News >
      CURRENT ISSUE

      May 2022

      • Aging in Place: Lifestyle Supplements Science-Based Solutions
      • Getting an Edge in Esports: Meeting Health & Nutrition Needs
      • Nutraceuticals for Men: Muscle Health and Performance Nutrition

      Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
      You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

      • About Us
      • Privacy Policy
      • Terms And Conditions
      • Contact Us

      follow us

      Subscribe
      Nutraceuticals World

      Latest Breaking News From Nutraceuticals World

      Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board
      Expert Consensus Statement: Diet is Best Primary Intervention to Achieve Diabetes Remission
      Choline Alone May Improve Maternal DHA Status During Pregnancy
      Coatings World

      Latest Breaking News From Coatings World

      Teknos Receives EcoVadis Gold Medal for Sustainability Performance
      AkzoNobel and Partners Team Up to Hack Carbon Reduction Challenges
      Five PPG Facilities in Ohio Recognized for Sustainability, Health, Safety Practices
      Medical Product Outsourcing

      Latest Breaking News From Medical Product Outsourcing

      VenoStent's SelfWrap Bioabsorbable Perivascular Wrap Earns Breakthrough Status
      Guard Medical Closes $11 Million Series B Investment
      OMNIVISION, Silicon Line Partner on Optical Fiber Endoscope Cables
      Contract Pharma

      Latest Breaking News From Contract Pharma

      Catalent Invests $175M to Expand Mfg. Capabilities at Winchester, KY
      Sartorius Expands Manufacturing Site in Tunisia
      BioMoti Partners with Pharma Company to Develop Ovarian Cancer Treatment
      Beauty Packaging

      Latest Breaking News From Beauty Packaging

      Garance Doré Launches Made in France Skincare Line
      The World’s Most Popular Perfumes & Celebrity Fragrances
      Ulta Beauty Launches Retail Media Network
      Happi

      Latest Breaking News From Happi

      Loum Beauty, Rare Beauty Launch #BeautyCares Voices
      ACI Urges Congress To Ensure Funding for EPA’s Office of Chemical Safety and Pollution Prevention
      Dr. Dana’s Nail Renewal System Relaunches Under Rare Beauty Brands
      Ink World

      Latest Breaking News From Ink World

      hubergroup Chemicals Exhibits at Paint India for First Time
      Award for Sustainability: Evonik Receives Platinum Rating Again
      Nazdar Ink Technologies to Showcase Latest Ink Innovations at FESPA Global Print Expo 2022
      Label & Narrow Web

      Latest Breaking News From Label & Narrow Web

      Dantex Group receives accreditation for Pico digital presses
      Heidelberg USA launches new Print Media Performance & Training Center
      Avery Dennison announces Global Supplier Award winners
      Nonwovens Industry

      Latest Breaking News From Nonwovens Industry

      'Right' Hygiene Conference to be Held in June
      Freudenberg to Present Battery Pack and Liquid Absorbers at Battery Show
      H&V Appoints Vice President and General Counsel
      Orthopedic Design & Technology

      Latest Breaking News From Orthopedic Design & Technology

      Paragon 28 Rolls Out TenoTac 2.0 Hammertoe and Soft Tissue Repair
      Cionic Expands Scientific Advisory Board
      First Surgeries Performed Using Globus Medical's Excelsius3D
      Printed Electronics Now

      Latest Breaking News From Printed Electronics Now

      NREL Creates Highest Efficiency 1-Sun Solar Cell
      eMagin Wins People’s Choice Award at Display Week 2022
      Wiliot Launches Battery-Assisted Version of its IoT Pixel Tags

      Copyright © 2022 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

      AD BLOCKER DETECTED

      Our website is made possible by displaying online advertisements to our visitors.
      Please consider supporting us by disabling your ad blocker.


      FREE SUBSCRIPTION Already a subscriber? Login