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    Industry News

    Unapproved Synthetic Stimulant Found in Multiple Dietary Supplements

    ...

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    11.03.14
    Researchers from global public health organization NSF International, Harvard Medical School and the National Institute for Public Health and the Environment in the Netherlands (RIVM) have found an unapproved synthetic stimulant—1,3-Dimethylbutylamine or DMBA—in 12 over-the-counter dietary supplements. The findings were published in the peer-reviewed journal Drug Testing and Analysis.

    This is an important finding, as DMBA is chemically similar to other harmful stimulants such as DMAA, which was banned by regulatory agencies in the U.S., U.K., The Netherlands, Brazil and elsewhere because of its links to negative health events such as strokes, heart failure and sudden death. There are no known safety studies on DMBA and its health effects are entirely unknown.

    “While regulatory authorities work to remove harmful stimulants such as ephedrine and DMAA from supplements, new synthetic stimulants such as DMBA continue to crop up to take their place,” said NSF International Senior Research Scientist John Travis.

    “Without proper studies, the health impact of this new stimulant is entirely unknown. We urge manufacturers, distributors, retailers and regulators to work together to remove this unapproved stimulant from the marketplace to help protect consumers from potentially harmful health effects.”

    “The literature states that this new drug has been tested on dogs and cats with severed spinal cords. It’s never been tested in humans. It is absurd that consumers are being exposed to adulterated over-the-counter workout and weight loss supplements sold at some of the largest supplement retailers in America. The risks are entirely unknown,” said Dr. Pieter Cohen, an assistant professor of medicine at Harvard Medical School. “The possibility to cause harm is real. It’s a close cousin of DMAA, which is currently being investigated as the cause of bleeding strokes, heart failure and sudden death,” said Dr. Cohen, who is also an internist at Cambridge Health Alliance. “It is essential to steer clear of this new drug.”

    Consumers are urged to avoid products containing this substance, which may be listed on product labels as “4-amino-2-methylpentane citrate,” “AMP citrate,” “1,3-dimethylbutylamine citrate,” “4-amino-2-pentanamine,” “Pentergy,” “4-AMP” or “extracted from pouchong tea.”

    Using ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS), NSF International and RIVM scientists found DMBA in 12 of the 14 dietary supplement products analyzed (85.7%) with DMBA content ranging from 13 to 120 mg per serving. According to the recommended daily intake on product labels, consumers of these products would ingest 26-320 mg of DMBA per day.

    A recent independent survey conducted on behalf of NSF International indicated that 51% of consumers are concerned about the safety and quality of dietary supplements.
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