09.01.14
Nutraceutical: Probiotics
Indication: Blood Pressure Control
Source: Hypertension (published online July 21, 2014)
Research: Previous human clinical trials have shown that probiotic consumption may improve blood pressure (BP) control. The aim of this systematic review was to clarify the effects of probiotics on BP using a meta-analysis of randomized, controlled trials. PubMed, Scopus, Cochrane Library (Central), Physiotherapy Evidence Database, and Clinicaltrial.gov databases were searched until January 2014 to identify eligible articles. Meta-analysis using a random-effects model was chosen to analyze the impact of combined trials. Nine trials were included.
Results: Compared to control, probiotic consumption significantly changed systolic BP by −3.56 mm Hg (95% confidence interval, −6.46 to −0.66) and diastolic BP by −2.38 mm Hg (95% confidence interval, −2.38 to −0.93). A greater reduction was found with multiple compared to single species of probiotics for both systolic and diastolic BP. Subgroup analysis of trials with baseline BP ≥130/85 mm Hg compared with <130/85 mm Hg found a more significant improvement in diastolic BP. Duration of intervention <8 weeks did not result in a significant reduction in systolic or diastolic BP. Subgroup analysis of trials with daily dose of probiotics <1,011 colony-forming units did not result in a significant effect. Analysis suggested that consuming probiotics may improve BP by a modest degree, with a greater effect when baseline BP is elevated, multiple species of probiotics are consumed, the duration of intervention is ≥8 weeks or daily consumption dose is ≥1,011 colony-forming units.
Indication: Blood Pressure Control
Source: Hypertension (published online July 21, 2014)
Research: Previous human clinical trials have shown that probiotic consumption may improve blood pressure (BP) control. The aim of this systematic review was to clarify the effects of probiotics on BP using a meta-analysis of randomized, controlled trials. PubMed, Scopus, Cochrane Library (Central), Physiotherapy Evidence Database, and Clinicaltrial.gov databases were searched until January 2014 to identify eligible articles. Meta-analysis using a random-effects model was chosen to analyze the impact of combined trials. Nine trials were included.
Results: Compared to control, probiotic consumption significantly changed systolic BP by −3.56 mm Hg (95% confidence interval, −6.46 to −0.66) and diastolic BP by −2.38 mm Hg (95% confidence interval, −2.38 to −0.93). A greater reduction was found with multiple compared to single species of probiotics for both systolic and diastolic BP. Subgroup analysis of trials with baseline BP ≥130/85 mm Hg compared with <130/85 mm Hg found a more significant improvement in diastolic BP. Duration of intervention <8 weeks did not result in a significant reduction in systolic or diastolic BP. Subgroup analysis of trials with daily dose of probiotics <1,011 colony-forming units did not result in a significant effect. Analysis suggested that consuming probiotics may improve BP by a modest degree, with a greater effect when baseline BP is elevated, multiple species of probiotics are consumed, the duration of intervention is ≥8 weeks or daily consumption dose is ≥1,011 colony-forming units.
