• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Health Products Association - China Executive Director Reflects on Market Dynamics, Challenges

    Blood Sugar Management: Personalized Testing Drives Home The Need for Early Intervention

    New and Evolving Formulation Options Must Be Mindful of Blood Sugar Maintenance

    Tapping Functional Beverages to Meet Modern Wellness Needs

    Adaptogens: Where Ancient Remedies Meet Modern Wellness Products
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    Pharmavite Expands in Ohio with $200 Million Investment

    Nestlé Health Science Expands in New Zealand with Deal to Buy The Better Health Company

    Younger Consumers Drive Growing Demand for Ingestible Beauty and Skin Care Products

    NOW Identifies Misleading Certificate of Analysis for Supplements Sold on Amazon

    Kensing Acquires Vitae Naturals
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    Kensing Acquires Vitae Naturals

    Lynside® Forte B offers full range of B-vitamin benefits with nutritional yeast

    CoQ10 and Royal Jelly Supplementation May Improve High Intensity Exercise

    Shiitake Mushroom Extract Appears Helpful in HPV Infections

    United Plant Savers Launches First Film Festival
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    Pharmavite Expands in Ohio with $200 Million Investment

    Nestlé Health Science Expands in New Zealand with Deal to Buy The Better Health Company

    Younger Consumers Drive Growing Demand for Ingestible Beauty and Skin Care Products

    NOW Identifies Misleading Certificate of Analysis for Supplements Sold on Amazon

    Kensing Acquires Vitae Naturals
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    Younger Consumers Drive Growing Demand for Ingestible Beauty and Skin Care Products

    Lynside® Forte B offers full range of B-vitamin benefits with nutritional yeast

    CoQ10 and Royal Jelly Supplementation May Improve High Intensity Exercise

    Shiitake Mushroom Extract Appears Helpful in HPV Infections

    Upcycled Coffeeberry® Cascara Offers Versatility in Functional Beverage Development
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    Gencor

    Verdure Sciences

    Ecuadorian Rainforest

    Nutrition21, LLC

    Botanic Healthcare LLC
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    Gencor

    Verdure Sciences

    Ecuadorian Rainforest

    Nutrition21, LLC

    Botanic Healthcare LLC
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Industry News

    Synutra Research Team Discovers Chondroitin Adulterant, Advises on Effective Testing Methods

    ...

    Related CONTENT
    • Nutralliance Adds Eggshell-Derived Ingredients for Beauty and Joint Health to Portfolio
    • Bioiberica Unveils DAOgest and Dermial at Vitafoods 2022
    • Safe Iberoamericana to Distribute Certified Nutraceuticals’ Collagen Products in Mexico
    • Active Nutrition Market Expands to Meet Modern Health Challenges
    • Botanical Formula Significantly Effects Knee Pain in Five Days, Study Finds
    06.12.14
    Weiguo Zhang, president of Synutra International, Rockville, MD, revealed that a recently discovered adulterant of chondroitin sulfate, which Synutra called Zero One (Z1), has been identified as sodium hexametaphosphate by a team of industry experts the company convened. He further advises the industry of the effective ingredient testing methods to separate this adulterant and ensure chondroitin purity and quality.

    Aishan Li, director of R&D and Quality Control of Meitek Technology, a Synutra subsidiary, first reported discovery of the new adulterant Z1 in 2013, confirming the suitability of electrophoresis as an effective screening tool for detecting impurities and adulterants in chondroitin. What remained was to discover the identity of Z1, of particular importance in case it was a substance that presented a health risk.

    A research group was established, pooling input and resources from the industry’s top scientists with chondroitin expertise in the U.S. The team included Synutra’s Weiguo Zhang, James Neal-Kababick, director of Flora Research Laboratories, Jana Hildreth, director of technology and scientific affairs of Synutra Pure, Gabriel Giancaspro, vice president of the United States Pharmacopeia (USP), Kristie Adams, a nuclear magnetic resonance spectroscopy scientist at USP and the late Dr. Mark Roman, director of Tampa Bay Analytical Research Laboratories, to whom the resulting research paper is dedicated.

    Over several months this team gathered preponderant evidence that Z1 is a form of polyphosphate salt, namely sodium hexametaphosphate.  "It is an industrial chemical that is inexpensive and easily available," said Neal-Kababick, who performed polarized light microscopy, elemental and infrared analyses of the suspect substance. "It is commonly used in detergent or as a water treatment agent, and is sold under the commercial name Calgon." 

    "Sodium hexametaphosphate may be ingested by humans in small amounts, but if the level of adulteration goes to about 10% of the supplement serving size, it depletes calcium from the body,” commented Ms. Hildreth.  “Its use in joint health supplements may pose serious safety and health risks to consumers.”

    The most commonly used chondroitin assay method, cetylpyridinium chloride (CPC) titration, can be fooled by various known adulterants. Synutra advocates using CPC after cellulose acetate membrane electrophoresis (CAME), a complementary methodology to CPC that has been in the USP monograph for years and was designed to screen out ingredient material impurities and keep the CPC assay true.  Currently in the industry most companies use only CPC, but few use CAME in their routine screening of incoming raw materials. “Of the known chondroitin adulterants identified to date, including sodium alginate, propylene glycol alginate sulfate sodium, and sodium hexametaphosphate, all can be separated out from chondroitin material by their difference in electrophoretic mobility,” noted Zhang, who performed CAME in Synutra’s Rockville, MD research laboratory.

    "We advocate widespread adoption of CAME as a qualitative, raw material screening tool before running quantitative methods such as CPC for assay, or other specific methods such as enzymatic HPLC. CAME is an inexpensive, simple, and effective procedure that can serve us well in effectively deterring the practice of adulterating chondroitin ingredients with known adulterants," said Zhang.  
     
    Because of the global nature of the supply chain, food and dietary supplement ingredients are susceptible to adulteration, particularly when price is the main purchasing criteria, and therefore must be sourced very carefully. In addition to the concern about potentially negative health impact of adulterants, manufacturers are vulnerable to FDA action when their label claims are inaccurate due to missing or misidentified ingredients, and consumers do not get the health benefits they expect when ingredients are not what they are supposed to be. “Because of the size and scope of the supply chain, it is imperative that all responsible companies be proactive in ensuring the purity and identity of ingredients,” Zhang said.

    Because chondroitin products are in the top five best selling dietary supplements, with annual sales of about $1 billion, and most chondroitin ingredient is sourced from overseas, chondroitin is often targeted for adulteration. Synutra, currently the largest supplier of chondroitin as a dietary ingredient in the world, started tracking and monitoring chondroitin adulteration in the supply chain three years ago. 

    The research team intends to publish its findings in a peer-reviewed journal, with details of the collaborative studies currently being finalized.  These efforts have opened up other potential pathways to develop new methodologies to detect chondroitin adulteration. 
    Related Searches
    • Dietary Supplements
    • Quality Control
    • Adulteration
    • Calcium
    Related Knowledge Center
    • Dietary Supplements
    Suggested For You
    Nutralliance Adds Eggshell-Derived Ingredients for Beauty and Joint Health to Portfolio Nutralliance Adds Eggshell-Derived Ingredients for Beauty and Joint Health to Portfolio
    Bioiberica Unveils DAOgest and Dermial at Vitafoods 2022 Bioiberica Unveils DAOgest and Dermial at Vitafoods 2022
    Safe Iberoamericana to Distribute Certified Nutraceuticals’ Collagen Products in Mexico Safe Iberoamericana to Distribute Certified Nutraceuticals’ Collagen Products in Mexico
    Active Nutrition Market Expands to Meet Modern Health Challenges Active Nutrition Market Expands to Meet Modern Health Challenges
    Botanical Formula Significantly Effects Knee Pain in Five Days, Study Finds Botanical Formula Significantly Effects Knee Pain in Five Days, Study Finds
    Active Lifestyles Lead Health Markets in Fresh Directions Active Lifestyles Lead Health Markets in Fresh Directions
    Lonza Capsules & Health Ingredients to Feature Innovative Clean Label Solutions Lonza Capsules & Health Ingredients to Feature Innovative Clean Label Solutions
    Beauty Ingredient Formulation Directory Fall 2021 Beauty Ingredient Formulation Directory Fall 2021
    TSI Group’s HMB Ingredient Receives Brazil’s ANVISA Registration TSI Group’s HMB Ingredient Receives Brazil’s ANVISA Registration
    Joint Support Dietary Supplement Offers Functional Support with Range of Active Ingredients Joint Support Dietary Supplement Offers Functional Support with Range of Active Ingredients
    Bioiberica Rebrands Range of Nutraceutical Ingredients Bioiberica Rebrands Range of Nutraceutical Ingredients
    BioCell Collagen®: Leveraging Decades of R&D to Deliver Added Value to CPG Brands BioCell Collagen®: Leveraging Decades of R&D to Deliver Added Value to CPG Brands
    NXT USA Launches Novel Joint Health Ingredient NXT USA Launches Novel Joint Health Ingredient
    Bioiberica Bioiberica's b-2cool Ingredient Shown to Improve Joint Mobility In Vivo
    Nature Nature's Bounty Unveils New Line of Premium Pet Supplements

    Related Breaking News

    • Bone & Joint Health | Breaking News | Dietary Supplements | Proteins, Peptides, Amino Acids | Skin Health | Supplier News | World Markets
      Nutralliance Adds Eggshell-Derived Ingredients for Beauty and Joint Health to Portfolio

      Nutralliance Adds Eggshell-Derived Ingredients for Beauty and Joint Health to Portfolio

      The two ingredients, Ovoderm and Ovomet, are rich in collagen.
      06.20.22

    • Bioiberica Unveils DAOgest and Dermial at Vitafoods 2022

      Bioiberica Unveils DAOgest and Dermial at Vitafoods 2022

      DAOgest shown to improve histamine digestion while Dermial combines hyaluronic acid, glycosaminoglycans, and hydrolysed collagen.
      05.12.22

    • Bone & Joint Health | Breaking News | Cognitive Function | Proteins, Peptides, Amino Acids | Skin Health | Supplier News | World Markets
      Safe Iberoamericana to Distribute Certified Nutraceuticals’ Collagen Products in Mexico

      Safe Iberoamericana to Distribute Certified Nutraceuticals’ Collagen Products in Mexico

      The exclusive sales and marketing distribution agreement will cover all five of its branded collagen products.
      03.21.22


    • Bone & Joint Health | Dietary Supplements | Sports Nutrition
      Active Nutrition Market Expands to Meet Modern Health Challenges

      Active Nutrition Market Expands to Meet Modern Health Challenges

      Brands can bridge attitude-behavior gaps among mass consumer groups with convenient, personalized, and clean-label solutions.
      By Mike Montemarano, Associate Editor 03.02.22

    • Bone & Joint Health | Breaking News | Dietary Supplements | Healthy Aging | Herbs & Botanicals | Medical Nutrition | Natural/Organic | Research | Research News
      Botanical Formula Significantly Effects Knee Pain in Five Days, Study Finds

      Botanical Formula Significantly Effects Knee Pain in Five Days, Study Finds

      Supplementing with NXT USA’s TamaFlex resulted in short-term improvement in self-reported pain scores and inflammatory markers at both high and low doses.
      01.25.22

    Loading, Please Wait..
    Trending
    • 3 grams of Omega-3s May be Optimal Dose for Reducing Blood Pressu
    • Three Grams Of Omega-3s May Be Optimal Dose For Reducing Blood Pressure
    • High Blood DHA Levels Linked To 49% Reduced Risk Of Alzheimer’s
    • CoQ10 And Royal Jelly Supplementation May Improve High Intensity Exercise
    • First Day Life Shuts Down Children's Behavioral, Cognitive Health Claims Following Challenge
    Breaking News
    • Pharmavite Expands in Ohio with $200 Million Investment
    • Nestlé Health Science Expands in New Zealand with Deal to Buy The Better Health Company
    • Younger Consumers Drive Growing Demand for Ingestible Beauty and Skin Care Products
    • NOW Identifies Misleading Certificate of Analysis for Supplements Sold on Amazon
    • Kensing Acquires Vitae Naturals
    View Breaking News >
    CURRENT ISSUE

    June 2022

    • Tapping Functional Beverages to Meet Modern Wellness Needs
    • Adaptogens: Where Ancient Remedies Meet Modern Wellness Products
    • New and Evolving Formulation Options Must Be Mindful of Blood Sugar Maintenance
    • Health Products Association - China Executive Director Reflects on Market Dynamics, Challenges
    • Blood Sugar Management: Personalized Testing Drives Home The Need for Early Intervention
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Pharmavite Expands in Ohio with $200 Million Investment
    Nestlé Health Science Expands in New Zealand with Deal to Buy The Better Health Company
    Younger Consumers Drive Growing Demand for Ingestible Beauty and Skin Care Products
    Coatings World

    Latest Breaking News From Coatings World

    Azelis Acquires Chemical Partners, Strengthens Leadership in Africa and Middle East
    Emmanuelle Bromet Named Arkema Sustainable Development VP
    ROSS Planetary Dual Dispersers Have Unique Processing Flexibility
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    MPO's Most-Read Stories This Week—July 2
    OmniGuide Awarded FDA Clearance for RevoLix Hybrid Thulium Laser
    Pancryos Forges License Agreement for Microencapsulation Device
    Contract Pharma

    Latest Breaking News From Contract Pharma

    Bayer Opens New Research and Innovation Center at Kendall Square
    Lonza Names Maria Soler Nunez as Head, Group Operations
    Eurofins DiscoverX Opens Shanghai Office
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Dexlevo Introduces Beauty Treatment technique, ‘GOURI’
    Revision Skincare Exec Wins Ernst & Young Entrepreneur of the Year
    Latest Updates About Cosmoprof North America
    Happi

    Latest Breaking News From Happi

    L’Oréal’s Solution for Gray Hair, Scotch Porter's New President & Boots No. 7 Beauty Is Not for Sale
    SCOTUS EPA Ruling Won’t Impact General Regulatory Authority
    Toning Collection For Zero-Brass Blondes is New at Colorproof
    Ink World

    Latest Breaking News From Ink World

    Weekly Recap: Flint OPS, Xerox and MNYPIA Top This Week’s News
    Azelis Acquires Chemical Partners, Adds to Leadership in Africa and Middle East
    International Paper Publishes 2021 Sustainability Report
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    UPM Raflatac boosts operations in US, All4Labels returns to HP and more
    Fedrigoni Self-Adhesives to exhibit at Labelexpo Americas for first time
    CELAB Europe wins Paper Recycling award
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Weekly Recap: Lifetime Technical Achievement Award Presented to Richard Knowlson, Alkegen Completes Luyang Acquisition & More
    Glatfelter, Blue Ocean Closures Partner with Absolut
    What You’re Reading on Nonwovens-Industry.com
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    ODT's Most-Read Stories This Week—July 2
    NuVasive Inc. Opens Singapore Experience Center
    Pedicle Screw Systems Market to Top $3B in 2027
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Weekly Recap: eMagin, Identiv, and Japan Display Top This Week’s Stories
    Epishine is Building a New Solar Cell Factory in Linköping, Sweden
    Toppan Establishes CVC Fund and Investment Management Company in the US

    Copyright © 2022 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login