This trial measured the effect of glutathione supplementation at 250 mg/day and 1,000 mg/day on glutathione levels in different blood components and exfoliated buccal mucosal cells over a six month period among 54 healthy adults (41 females/13 males), 28-72 years of age (mean = 46.6 years).
Results of the study showed glutathione levels in the blood increased after one, three and six months vs. baseline at both doses. At six months, mean glutathione levels increased 30-35% in erythrocytes, plasma and lymphocytes, and 260% in buccal cells in the high dose group (P<0.05). Glutathione levels increased 17% and 29% in blood and erythrocytes, respectively, in the low dose group (P<0.05).
A reduction in oxidative stress in both glutathione dose groups was indicated by decreases in the oxidized to reduced glutathione ratio in whole blood after 6 months.
According to the study, the effects of glutathione supplementation on the levels of the glutathione precursor cysteine in plasma and the activity of the rate-limiting glutathione biosynthetic enzyme GCL in erythrocytes were examined after the six-month study period. No changes were observed in cysteine concentrations or GCL activity in any of the groups. This study was supported by Kyowa Hakko USA, Inc. and Kyowa Hakko Bio. Ltd.
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