12.26.13
The Journal of Nutrition & Metabolism has published a study that demonstrates the beneficial effects of the Health Enhancement Products, Inc.’s proprietary algal culture in supporting healthy cholesterol balance. Results found that fractions and isolates derived from HEPI’s proprietary algae culture “PAZ” (formerly referred to as “ProAlgaZyme”) were shown to be a viable candidate for supporting healthy cholesterol balance, in sharp contrast to the control group.
The project, led by Smiti Gupta, Ph.D., associate professor of nutrition and food science at Wayne State University, involved monitoring lipid metabolism in a widely accepted animal model for investigating human lipid metabolism. The scientific paper describes a follow-up study to the original research conducted by Dr. Gupta.
The test subjects in the recent study consumed a high fat diet for four weeks, at which point they became hypercholesterolemic (i.e. they had high plasma cholesterol levels.). Subsequently, the animals were given the extracts for 0 (untreated), 3, 7, 10, 14, and 21 days while still on the high fat diet. The results indicated that the PAZ extracts may be a useful option for improving the plasma cholesterol profile despite the hypercholesterolemic state induced by a high fat diet.
Specifically, “bad” cholesterol concentrations significantly decreased in all subjects consuming the PAZ extracts, compared to those who were not treated. Furthermore, increased levels of “good” cholesterol could be seen as early as day three for that same group. By day 21, “good” cholesterol levels increased by 28% and “bad” cholesterol levels decreased by 30%.
Additionally, metabolomics analysis was conducted to analyze the concentration of certain metabolites (small molecules which are byproducts of normal metabolic functions) in the blood. Administering the PAZ extract correlated with significantly decreased levels of several metabolites that are independent predictors of increased risk of atherosclerosis and cardiovascular disease.
Gene expression analysis was also conducted, to get a deeper insight into the increase in plasma HDL-c levels. Thus the expression levels (mRNA) of proteins involved in HDL-c metabolism were evaluated. By day 10, subjects showed a threefold increase in the gene expression of APO A1, a major protein associated with the production of HDL particles, the “good” cholesterol which increased sixfold by day 21.
For more information: http://health-enhancement-products.com
The project, led by Smiti Gupta, Ph.D., associate professor of nutrition and food science at Wayne State University, involved monitoring lipid metabolism in a widely accepted animal model for investigating human lipid metabolism. The scientific paper describes a follow-up study to the original research conducted by Dr. Gupta.
The test subjects in the recent study consumed a high fat diet for four weeks, at which point they became hypercholesterolemic (i.e. they had high plasma cholesterol levels.). Subsequently, the animals were given the extracts for 0 (untreated), 3, 7, 10, 14, and 21 days while still on the high fat diet. The results indicated that the PAZ extracts may be a useful option for improving the plasma cholesterol profile despite the hypercholesterolemic state induced by a high fat diet.
Specifically, “bad” cholesterol concentrations significantly decreased in all subjects consuming the PAZ extracts, compared to those who were not treated. Furthermore, increased levels of “good” cholesterol could be seen as early as day three for that same group. By day 21, “good” cholesterol levels increased by 28% and “bad” cholesterol levels decreased by 30%.
Additionally, metabolomics analysis was conducted to analyze the concentration of certain metabolites (small molecules which are byproducts of normal metabolic functions) in the blood. Administering the PAZ extract correlated with significantly decreased levels of several metabolites that are independent predictors of increased risk of atherosclerosis and cardiovascular disease.
Gene expression analysis was also conducted, to get a deeper insight into the increase in plasma HDL-c levels. Thus the expression levels (mRNA) of proteins involved in HDL-c metabolism were evaluated. By day 10, subjects showed a threefold increase in the gene expression of APO A1, a major protein associated with the production of HDL particles, the “good” cholesterol which increased sixfold by day 21.
For more information: http://health-enhancement-products.com
