A randomized, placebo-controlled, double-blind, parallel-group clinical trial was conducted, with 170 perimenopausal women given either placebo or 30 mg of Pycnogenol twice per day, over a period of 12 weeks.
The rationale of the study was to identify menopausal symptoms that respond well to supplementation with a low dosage of Pycnogenol. Researchers found that Pycnogenol is most effective for lowering hot flashes and night-time sweating. The study found that thermal dysregulation may relate to the inability of menopausal women to radiate off excess heat because peripheral blood vessels insufficiently expand. Pycnogenol supports vascular relaxation, which allows the body to rid of excess body heat, subsiding the sensation of hot flashes and night-time sweating. The report emphasizes the increased general risk for cardiovascular health problems of menopausal women, which may benefit from the improved vascular function with Pycnogenol. The discovery of lowered heart palpitations in women taking Pycnogenol in this study provides further support to this point.
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