03.01.13
Nutraceutical: B Vitamins
Indication: Colorectal Cancer
Source: American Journal of Clinical Nutrition, January 2013
Research: This study investigated associations between intakes of folate, riboflavin, vitamin B6 and vitamin B12 and colorectal cancer (CRC) in the Women’s Health Initiative Observational Study, stratified by time exposed to folic acid fortification and alcohol intake. A total of 88,045 postmenopausal women were recruited during 1993–1998; 1,003 incident CRC cases were ascertained as of 2009. Quartiles of dietary intakes were compared; HRs and 95% CIs were estimated by Cox proportional hazards models.
Results: Dietary and total intakes of vitamin B6 in quartile 4 compared with quartile 1 (HR: 0.80; 95% CI: 0.66, 0.97 and HR: 0.80; 95% CI: 0.66, 0.99, respectively) and total intakes of riboflavin (HR: 0.81; 95% CI: 0.66, 0.99) were associated with reduced risk of CRC overall and of regionally spread disease. In current drinkers who consumed < 1 drink (13 grams of alcohol)/week, B vitamin intakes were inversely associated with CRC risk (P-interaction < 0.05). Dietary folate intake was positively associated with CRC risk among women who had experienced the initiation of FA fortification for 3 to < 9 years (P-interaction < 0.01). Vitamin B6 and riboflavin intakes from diet and supplements were associated with a decreased risk of CRC in postmenopausal women. Associations of B vitamin intake were particularly strong for regional disease and among women drinkers who consumed alcohol infrequently. Researchers concluded this study provides new evidence that the increased folate intake during the early postfortification period may have been associated with a transient increase in CRC risk.
Indication: Colorectal Cancer
Source: American Journal of Clinical Nutrition, January 2013
Research: This study investigated associations between intakes of folate, riboflavin, vitamin B6 and vitamin B12 and colorectal cancer (CRC) in the Women’s Health Initiative Observational Study, stratified by time exposed to folic acid fortification and alcohol intake. A total of 88,045 postmenopausal women were recruited during 1993–1998; 1,003 incident CRC cases were ascertained as of 2009. Quartiles of dietary intakes were compared; HRs and 95% CIs were estimated by Cox proportional hazards models.
Results: Dietary and total intakes of vitamin B6 in quartile 4 compared with quartile 1 (HR: 0.80; 95% CI: 0.66, 0.97 and HR: 0.80; 95% CI: 0.66, 0.99, respectively) and total intakes of riboflavin (HR: 0.81; 95% CI: 0.66, 0.99) were associated with reduced risk of CRC overall and of regionally spread disease. In current drinkers who consumed < 1 drink (13 grams of alcohol)/week, B vitamin intakes were inversely associated with CRC risk (P-interaction < 0.05). Dietary folate intake was positively associated with CRC risk among women who had experienced the initiation of FA fortification for 3 to < 9 years (P-interaction < 0.01). Vitamin B6 and riboflavin intakes from diet and supplements were associated with a decreased risk of CRC in postmenopausal women. Associations of B vitamin intake were particularly strong for regional disease and among women drinkers who consumed alcohol infrequently. Researchers concluded this study provides new evidence that the increased folate intake during the early postfortification period may have been associated with a transient increase in CRC risk.
