• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Brain Health: A Mysterious Frontier

    State of the Industry: Positive Market Outlook Despite COVID-19 Turmoil

    2021 International Buyers' Guide

    A Health Gap: Disparity in Immunity & Well-Being in 2020

    Glass or Plastic: Understanding the Complete Costs & Sustainability Impact
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    Brown Fat Associated with Reductions in Chronic Disease Risk

    NIH Study Identifies Antibacterial Properties in Taurine

    NSF Begins New Certification Program

    Eriocitrin Shown to Have Metabolic Benefits in Recent Study

    EverGrain Introduces Sustainable Barley Ingredients
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    NIH Study Identifies Antibacterial Properties in Taurine

    Eriocitrin Shown to Have Metabolic Benefits in Recent Study

    EverGrain Introduces Sustainable Barley Ingredients

    AHPA Requests FDA Take a New Approach on Produce Regulation Affecting Herbs

    Preliminary Study Suggests Link Between Omega-3s and Lower COVID-19 Death Rates
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    Brown Fat Associated with Reductions in Chronic Disease Risk

    NIH Study Identifies Antibacterial Properties in Taurine

    NSF Begins New Certification Program

    Eriocitrin Shown to Have Metabolic Benefits in Recent Study

    EverGrain Introduces Sustainable Barley Ingredients
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    Brown Fat Associated with Reductions in Chronic Disease Risk

    NIH Study Identifies Antibacterial Properties in Taurine

    Eriocitrin Shown to Have Metabolic Benefits in Recent Study

    EverGrain Introduces Sustainable Barley Ingredients

    Preliminary Study Suggests Link Between Omega-3s and Lower COVID-19 Death Rates
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    AIDP

    Verdure Sciences

    KLK OLEO - Davos Life Science

    Indena USA, Inc.

    Vesta Nutra
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    Xsto Solutions

    KLK OLEO - Davos Life Science

    Vesta Nutra

    Bioenergy Life Science, Inc. (BLS)

    Indena USA, Inc.
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • eBook
    • Infographics
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Features

    A New Paradigm for Bone Health

    There’s a new sheriff in town, along with a new role for nutraceuticals.

    Related CONTENT
    • Brain Health: A Mysterious Frontier
    • Gencor Introduces Water-Dispersible Version of Veri-te Resveratrol
    • Rat Study Shows High Doses of Alpha Tocopherols Don’t Lead to Bone Loss
    • Branded Ingredient Showcase
    • Skeleton Crew: Solutions for Bone Health
    Case Adams, PhD, Contributing Writer04.01.12
    Osteoporosis afflicts more than 75 million people in the U.S., Europe and Japan; and 44 million Americans have osteoporosis, according to recent World Health Organization (WHO) and National Institutes of Health (NIH) reports.
     
    One in two women over 60 years of age will have an osteoporosis fracture, and 10-20% with hip fractures die within six months. The 1.6 million hip fractures occurring each year in developed countries are estimated to increase to 6.3 million by 2050 as the world’s 65-and-older population grows from 524 million to 1.5 billion—and from 38 million to 85 million in the U.S.
     
    Besides aging, generally accepted risk factors for osteoporosis include smoking, alcohol and caffeine consumption, lack of exercise and poor nutrition—all highest among developed countries.
     
    According to Transparency Market Research, Albany, NY, the global osteoporosis drug market has grown an average of 20% per year over 2009’s $6.8 billion. Bone health supplements are also growing, but at a slower pace. According to estimates from Nutrition Business Journal (NBJ), Boulder, CO, U.S. consumer sales of bone supplements reached $1.8 billion in 2010, representing 6% growth over 2009.
     
    According to data from SPINS, Schaumburg, IL, bone supplement sales grew 9.3% from 2010 to 2011 in combined U.S. channels. The conventional channel grew 12.4%. Vitamin D led in volume, growing 11.8%. Calcium volume followed, but grew only 4.1%. Vitamin K was last in total channel volume, but grew a hearty 23.7% in the natural channel. Magnesium sales grew 18.2% in total channel sales, and DHA sales grew 6.6%. Fish oil sales fell 1% during the year and bone-health multivitamins fell hard with a drop of 18.2%. Calcium sales in the natural channel dropped nearly 1%.
     
    Cracks in the ‘Bricks and Mortar’
     
    Calcium and calcium-plus-multivitamin weakness may come in part from two 2011 studies that received significant press coverage: one showing more cardiovascular events among women taking calcium; and another showing increased mortality among older women taking multivitamins.
     
    Lackluster calcium research—showing only 16% fractures reduction after three years of 1000 mg calcium plus 400 IU vitamin D3 supplementation among 4957 volunteers—points to another issue. The “bricks and mortar” hypothesis of bone health—that bone health is achieved through bioavailability of calcium (“bricks”) along with phosphorus and other elements (“mortar”)—has some major flaws, or cracks, as it were.
     
    An early crack getting more attention is research led by Harvard nutrition professor and leading Department of Agriculture nutritionist Dr. Mark Hegsted. Dr. Hegsted’s 1986 study, published in the Journal of Nutrition, found that countries consuming more calcium had higher hip fracture rates. The U.S. topped this list followed by New Zealand and Sweden—all top calcium-consuming countries.
     
    Research at the University of Hong Kong in 1996 confirmed that hip fractures among the Chinese and Taiwanese were 40-50% lower than American rates.
     
    In a 2001 review of continued research, Dr. Hegsted wrote in the American Journal of Nutrition, “Although high calcium intakes have long been recommended to prevent osteoporosis, there is little evidence that high calcium intakes effectively prevent fractures. Osteoporotic fractures are, like coronary artery disease, largely a disease of Western societies.” The data, illustrating “increasing evidence that diets high in fruit and vegetables are beneficial in preventing fractures, suggest common dietary etiologic factors.”
     
    Confounding Bone Density
     
    Low bone mineral density (BMD) is commonly equated with osteoporosis and bone fractures, and high BMD with health. Yet two decades of epidemiologic data indicate only about half of osteoporosis-related fracture sufferers have low bone density, or osteopenia.
     
    A Swedish review spanning 90,000 person years and 2000 bone fractures found bone density is not an accurate indicator of an individual’s risk of fracture. “We do not recommend a program of screening menopausal women for osteoporosis by measuring bone density,” the researchers stated.
     
    Reliance on bone density scans to gauge fracture risk is no longer acceptable. Today, the gold standard for determining fracture risk is FRAX, or Fracture Risk Assessment. FRAX factors include country of origin, clinical history, age, gender, body mass index, ethnicity, smoking, alcohol use, glucocorticoid use and rheumatoid arthritis along with osteoporosis symptoms and bone density measurements. Initially developed by WHO clinicians, FRAX is now embraced in the National Osteoporosis Foundation Clinician’s Guide and the National Osteoporosis Foundation Guide.
     
    As far as high BMD being healthier, research published in the Journal of the American Medical Association (JAMA) found higher BMD levels linked to breast cancer. Following 6854 women over the age of 65 found breast cancer incidence 30-50% higher for every BMD unit increase.
     
    Additionally, research by Michael Nevitt, PhD, MPH, and fellow University of California researcher Nancy Lane, MD, found high BMD levels linked to increased osteoarthritis incidence.
     
    The Metabolic Bone
     
    Michael McBurney, PhD, FACN, chairman of the Senior Scientific Advisory Committee at the Council for Responsible Nutrition (CRN), adjunct professor at Tufts University and head of scientific affairs at DSM Nutritional Products North America, Parsippany, NJ, clarified the nature of bones. “Despite their apparent rigidity, bones are metabolically active,” he noted. “Bone constantly remodels through bone resorption mainly by osteoclasts, and bone formation mainly by osteoblasts. As people age, bones may become brittle or osteoporotic when osteoclast activity exceeds osteoblast activity.”
     
    “Metabolically active” departs from the “bricks and mortar” thesis, but minerals are still the major component. “Bone,” said Dr. McBurney, “is composed of minerals (50-70%), an organic matrix (20-40%), water and lipid.”
     
    “Bones are a living substance and calcium is one important building element,” added Mona Møller, PhD, chief science officer of Norway-based Kappa Bioscience AS. “Bone mass increases until the early 20s, when it starts to decline. After 30 years of age, bone mass is decreasing in both men and women.”
     
    A New Sheriff in Town
     
    In 2005, researchers at Korea’s University of Ulsan College of Medicine found osteopenia and osteoporosis linked to 54% and 35% higher C-reactive protein (CRP) levels, respectively, among 4693 pre- and postmenopausal women. They also found significantly higher total alkaline phosphatase (ALP).
     
    Both markers—CRP and ALP—indicate systemic inflammation. They are prevalent in cardiovascular disease and other inflammatory disorders. “These findings suggest that subclinical systemic inflammation may be associated with bone turnover rate and bone mass in healthy women,” the researchers stated.
     
    University of Aberdeen Medical School researchers found the pro-inflammatory nitric oxide synthase pathway activated in osteoporosis. Sufferers had up to 344% higher nitric oxide levels, and higher pro-inflammatory nitric oxide levels yielded 64% lower bone density than controls.
     
    Anthony Yun, MD, and Patrick Lee, MD, from Stanford University have linked osteoporosis to inflammation, and a flurry of research has confirmed the hypothesis. University studies from around the world have established that low BMD and osteoporosis are associated with pro-inflammatory mediators IL-1β, IL-6, TNF-α, as well as RANK/RANKL.
     
    University of Zurich researchers characterized osteoporosis as relating to “systemic inflammation, oxidative stress, hypoxia and sympathetic activation.”
     
    University of Maryland research led by Natalie Silverman, MD, found aerobic exercise decreased bone loss together with inflammation markers IL-6 and TNF-α among 86 postmenopausal overweight women.
     
    The Sheriff’s Deputies
     
    Research has also been pinpointing the mechanisms. Last year, Scranton Commonwealth Medical College research confirmed bone’s remodeling processes are regulated by an extracellular protein called connective tissue growth factor (CTGF).
     
    CTGF regulates the building of blood vessel walls, joints and other tissues, as well as the repair and regeneration of bone matrix by osteoblasts. CTGF uses an immune system signaling cytokine called TGF-β1. TGF-β1 is expressed by regulating T-cells (rT-cells), which also regulate inflammatory wound repair.
     
    Yet over-expressed CTGF (and TGF-β) drives bone turnover overboard, inhibiting bone morphogenetic proteins (BMPs) that mitigate bone loss.
     
    BMP7, however, can shut down CTGF expression, halting TGF-β1 and bone loss. BMP7 rearranges priorities between mesenchymal stem cells, osteoblasts and osteoclasts, encouraging bone growth.
     
    University of Amsterdam researchers found BMP7 expressed in mechanical loading, connecting weight-bearing to increased bone strength. Vitamin D apparently stimulates BMP7 as well.
     
    BMPs regulate the matrix metalloproteinase (MMP) enzymes produced by osteoclasts and osteoblasts. These govern bone strength. BMP7s are also expressed in cancer, and they inhibit vascular calcification, or hardening of the arteries.
     
    TGF-β1 and NF-kB are the key mediators in bone loss. While T-cell-produced TGF-β1 regulates bone remodeling, NF-kB regulates inflammatory bone loss at the genetic level. NF-kB can be stimulated by TNF-α, IL-1 and others. Meanwhile, TGF-β1 modulates IL-1, IL-2 receptors, IL-6 and others. These countervailing inflammatory mediators—NF-kB and TGF-β1—provide key mechanisms linking bone loss to inflammation.
     
    Illustrating this notion, German researchers isolated osteoblasts from femurs of patients undergoing total hip replacement. TGF-β1 mediators proliferated among the osteoblasts. They reduced osteocalcin, increased osteopontin and decreased BMPs, accelerating bone loss.
     
    Vanderbilt University researchers found TGF-β1 increases parathyroid hormone-related protein (PTHrP) activity by stimulating the Gli2 signaling molecule, speeding bone loss.
     
    In other words, bone loss is an inflammatory event.
     
    Implications of Inflammatory Bone Loss
     
    Harvard School of Public Health researcher Dallas Jones, PhD, has characterized the study of inflammatory bone loss as “osteoimmunology.” University of Lille Nord de France researchers have dubbed the mechanism “inflammaging.”  “Inflammaging may be the driving force in age-related bone loss and may even be responsible for osteoporosis due to estrogen deficiency,” they stated. “The latter is illustrated by a 2-4-fold increase in the levels CRP or IL-6.”
     
    Gregory Mundy, MD, former professor of medicine at Vanderbilt University and the author of more than 500 scientific papers, found inflammation at the heart of osteoporosis. “Human and animal experiments have implicated pro-inflammatory cytokines as primary mediators of the accelerated bone loss at menopause including IL-1, TNF-α, and IL-6.”
     
    Dr. Paul Lacativa, bone researcher and professor of Clinical Medicine at the State University of Rio de Janeiro, stated, “several inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, celiac disease, cystic fibrosis and chronic obstructive pulmonary disease have been associated with bone resorption. The link between osteoclast, macrophage colony stimulating factor and pro-inflammatory cytokines, especially TNF-α and IL-1 explain the association between inflammation and osteoporosis.”
     
    Bone loss has also been associated with HIV/AIDS, various cancers, sarcoidosis, amyloidosis, cardiovascular disease, kidney disorders, diabetes and others.
     
    Dr. Lacativa believes the discovery offers new clinical realities: “I firmly believe that the relationship between inflammation and osteoporosis is a field that can reveal answers to many questions we face in our clinical practice. For example, I just finished a study—not yet published—that connects lumbar pain with hypovitaminosis D. How can we explain this connection? By the relationship between vitamin D and inflammation.
     
    “The problem,” he continued, “is how to control all the cytokines, since they have numerous functions in the body. Vitamin D appears as a good modulator, but we need more studies to explore that.”
     
    Metabolic Acidosis
     
    Lynda Frassetto, MD, clinical professor of Medicine at UCSF and internist at the UCSF Medical Center, analyzed hip fracture rates among 33 countries. Her research established that countries with higher plant-based protein consumption have lower rates of hip fractures. This confirmed research, led by Yale professor Dr. Benjamin Abelow, which analyzed 34 studies from 16 countries, finding hip fracture rates lowest among higher plant-protein-consuming countries.
     
    Research led by University of California professor Deborah Sellmeyer, MD, followed 1035 elderly women for seven years. Those who ate a higher ratio of plant-proteins suffered less bone loss and fractures after controlling for other possible effects.
     
    Dr. Frassetto related this effect to metabolic acidosis. “Our group has shown that contemporary net acid-producing diets characteristically produce a low-grade systemic metabolic acidosis in otherwise healthy adult subjects, and the degree of acidosis increases with age.”
     
    Minerals & Alkalinity
     
    Dr. Frassetto found that administering NaCl (salt) increased urinary calcium excretion and bone loss, while potassium bicarbonate (KHCO3), “improved calcium and phosphorus balances, reduced bone resorption rates, improved nitrogen balance and mitigated the normally occurring age-related decline in growth hormone secretion.”
     
    Research led by Linda Massey, PhD, RD, professor of Human Nutrition and Dietetics at Washington State University, has also found salt consumption deleterious to bone health. “Dietary salt over the recommended amounts directly causes urinary calcium loss. The loss of calcium is compensated for by taking calcium from bone. In a recent metabolic study we found all [salt-consuming] subjects lost calcium, but amounts ranged from modest to severe,” explained Dr. Massey.
     
    Healthy bones relate to more than calcium, potassium and salt for mineral balancing, according to expert Lawrence Wilson, MD. In addition to calcium and vitamin D, Dr. Wilson suggested that magnesium, manganese, copper, boron, selenium, zinc and vanadium are all critical for bone metabolism. “The bone matrix must be strong, not just having enough minerals in the bones,” Dr. Wilson added. “This is a cartilage type of substance that requires dozens of nutrients for its health. Removing metals like lead and aluminum is imperative as well.”
     
    A broad range of minerals and trace elements also promote alkaline metabolism. “Bioactivity and optimal mineral levels increase bone mineral content and enhance bone integrity. Good mineral nutrition depends on more than just calcium,” said Cristina Munteanu, scientist, technical service, with Corn Products International, Inc., Westchester, IL.
     
    Dr. Frassetto’s solution is alkalinity. “My belief is that it depends in part on the acid loads from protein intake—and it is the balance of acid and non-acid foods that is important.”
     
    This balance, Dr. Frassetto suggested, “would entail increasing consumption of potassium-rich net-base-producing fruits and vegetables for maintenance of energy balance and greatly reducing sodium chloride consumption.”
     
    Anti-Inflammatory Vitamins D and K
     
    Dr. Lacativa suggests that vitamin D’s effects—linked to more than 70 inflammatory disorders—relate to its ability to modulate inflammation. Whatever the mechanism, the research is clear. “A meta-analysis of randomized controlled trials among older individuals published in 2009 by Bischoff-Ferrari and colleagues found serum 25(OH)D levels inversely correlated with fractures,” said DSM’s Dr. McBurney.
     
    “The International Osteoporosis Foundation recommends maintaining serum 25(OH)D levels of at least 75 nmol/L (30 ng/mL). This will probably require between 800-2000 IU of vitamin D3 daily. Research shows vitamin D3 is more potent in raising serum 25(OH)D levels than vitamin D2,” Dr. McBurney added.
     
    University of Alberta researchers linked bone loss among celiac children to deficiencies in both vitamin D and K. Japan’s approval of vitamin K2 treatment for osteoporosis drew from a Kagoshima University study that found a year’s supplementation suppressed bone loss among 72 postmenopausal women.
     
    A 2009 Keio University School of Medicine review found high dose vitamin K1 and K2 supplementation “improved indices of bone strength in the femoral neck and reduced the incidence of clinical fractures.”
     
    Vitamin K is also essential for blood clotting, wound healing and inhibiting blood vessel calcification. “Vitamin K serves as a co-factor for γ-glutamyl-carboxylase, which activates Gla-proteins,” said Dr. Møller of Kappa Bioscience. “These gamma-carboxy glutamate (Gla) residues form calcium-binding sites. Vitamin K helps activate osteocalcin in bone and matrix Gla-protein (MGP) in the vessel wall.”
     
    Dr. Møller referenced a University of Bergen, Norway study of 1238 elderly men and 1569 elderly women that found K1 deficiency increased hip fracture risk by 57%.”
     
    Dr. Møller also discussed vitamin K’s relationship to inflammation. “The anti-inflammatory transcription factor NF-kB seems to be influenced by vitamin K2—a central player in chronic inflammation—through a set of genes encoding pro-inflammatory cytokines such as IL-1, IL-2, IL-6, TNF-α and monocyte chemotactic protein-1. What is common to all these molecules is that they are regulated by NF-kB.”
     
    “Very high doses of vitamin K1 (1-5 mg) or MK-4 (45 mg) are required to show effects on bone strength or fracture incidences in postmenopausal women,” she continued. “These dosages are much higher than multivitamin doses, which typically contain 50-100 mcg (vitamin K1). Studies on vitamin K2/MK-7 are mainly based on natto intake—a traditional Japanese fermented soybean dish. Numerous studies demonstrate a link between natto and fracture reduction, bone strength and improved BMD with an intake equivalent to between 50-200 mcg MK-7/day for three years.”
     
    Estrogen & Phytoestrogens
     
    INSERM researcher Thierry Thomas, MD, PhD, has linked reduced estrogen to inflammation and subsequent bone loss. “Bone metabolism is mainly under estrogenic control,” he stated. “Indeed, T-cells are activated by estrogen deficiency and produce pro-inflammatory cytokines such as TNF-α, which stimulates osteoclastogenesis both directly and indirectly through the RANKL pathway.”
     
    “Prospective epidemiologic studies in Asian populations have associated isoflavone intakes with a reduced risk of bone fracture,” DSM’s Dr. McBurney added. “Increases in spinal and hip BMD have been measured after genistein supplementation.” He pointed to a study of 70 volunteers published in the European Journal of Nutrition this January finding soy isoflavone genistein in combination with vitamin D3, vitamin K1 and omega 3s increased bone density. Animal research has also found soy isoflavones raise BMD levels and reduce estrogen-deficiency related bone loss.
     
    University of Melbourne researchers surveyed the diets and lifestyles of 354 postmenopausal women and found those who consumed more soy foods had fewer menopausal symptoms and less bone loss. However, those consuming more soy also ate more whole foods, fruits and vegetables, smoked less and exercised more—all inflammation moderators.
     
    A New Vision for Nutraceuticals
     
    A cursory review of the research literature indicates many nutraceuticals moderate TGF-β, NF-kB and other bone inflammatory pathways. These include resveratrol, quercetin, grape seed extract, omega 3s, astragalus, vitamin D, selenium, curcumin, saikosaponin, N-acetylcysteine, rosmarinic acid, Pycnogenol, strontium, astaxanthin, vitamin K, vitamin E and many others.
     
    Not surprisingly, some new research finds nutraceuticals can help prevent bone loss. University research has found tocotrienols protect osteoblasts against oxidative stress; tocotrienols and alpha-tocopherols suppress IL-1 and IL-6; and tocotrienols and alpha-tocopherols restore bone calcium loss in vivo.
     
    In a German study of seven healthy volunteers, five days of Pycnogenol supplementation significantly reduced MMP-9 and NF-kB levels. “Pycnogenol normalizes the sensitivity of NF-kB to avoid inflammation from being triggered,” explained Frank Schonlau, PhD, scientific director for Horphag Research, Geneva, Switzerland. Pycnogenol also reduced CRP levels in a 2008 Italian study of 156 osteoarthritis patients.
     
    Many herbs are authenticated anti-inflammatory agents, yet herb/bone studies have been rare. Kyung Hee University School of Medicine researchers gave Siberian ginseng (Eleutherococcus senticosus) extract plus 500 mg of calcium daily or just the calcium to 81 postmenopausal women with osteopenia or osteoporosis. After six months, the ginseng group had significantly higher serum osteocalcin levels, indicating bone remodeling benefits.
     
    Whole herbs and green foods can also apply Dr. Frassetto’s conclusions, as they provide potassium-rich alkalizing minerals, trace elements and phytonutrients.
     
    “Eicosanoids derived from omega 3 fatty acids, eicosapentaenoic (EPA) and docosahexaenoic (DHA) are less inflammatory than eicosanoids derived from omega 6 fatty acids,” Dr. McBurney stated. “Thus, increasing one’s intake of EPA and DHA can help reduce pro-inflammatory signals to mediate inflammation. Research has established that high intakes of DHA are positively associated with bone mineral accrual and peak BMD.”
     
    More than 200 studies have illustrated that prebiotics are another bone health nutraceutical. Corn Product’s Ms. Munteanu clarified the mechanism, saying “The production of short chain fatty acids in the gastrointestinal tract helps nourish the gut tissues through which minerals are absorbed and at the same time lower pH to an optimal level.”
     
    While more research applying anti-inflammatory nutraceuticals to bone loss disorders will be necessary, the door has been flung open. It’s a new day for nutraceuticals in the bone health category. And there’s a new sheriff in town.
     
    About the author: Case Adams is a California Naturopath with a PhD in Natural Health Sciences, and the author of several books on natural health. He is also the president of Realnatural, Inc. and can be contacted at ca@caseadams.com.
     

    References
    1. Riggs BL, Melton LJ 3rd. The worldwide problem of osteoporosis: insights afforded by epidemiology. Bone. 1995 Nov;17(5 Suppl):505S-511S.
    2. Bolland MJ, Avenell A, Baron JA, Grey A, MacLennan GS, Gamble GD, Reid IR. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ. 2010 Jul 29;341:c3691.
    3. Mursu J, Robien K, Harnack LJ, Park K, Jacobs DR Jr. Dietary supplements and mortality rate in older women: the Iowa Women’s Health Study. Arch Intern Med. 2011 Oct 10;171(18):1625-33.
    4. Larsen ER, Mosekilde L, Foldspang A. Vitamin D and calcium supplementation prevents osteoporotic fractures in elderly community dwelling residents: a pragmatic population-based 3-year intervention study. J Bone Miner Res. 2004 Mar;19(3):370-8.
    5. Hegsted DM. Calcium and osteoporosis. J Nutr. 1986 Nov;116(11):2316-9. PubMed PMID: 3794834. Siris ES, Baim S, Nattiv A. Primary care use of FRAX: absolute fracture risk assessment in postmenopausal women and older men. Postgrad Med. 2010 Jan;122(1):82-90.
    6. Ho SC. Body measurements, bone mass, and fractures. Does the east differ from the west? Clin Orthop Relat Res. 1996 Feb;(323):75-80.
    7. Siris ES, Baim S, Nattiv A. Primary care use of FRAX: absolute fracture risk assessment in postmenopausal women and older men. Postgrad Med. 2010 Jan;122(1):82-90.
    8. Marshall D, Johnell O, Wedel H. Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ. 1996 May 18;312(7041):1254-9.
    9. Cauley JA, Lucas FL, Kuller LH, Vogt MT, Browner WS, Cummings SR. Bone mineral density and risk of breast cancer in older women: the study of osteoporotic fractures. Study of Osteoporotic Fractures Research Group. JAMA. 1996 Nov 6;276(17):1404-8.
    10. Lane NE, Nevitt MC. Osteoarthritis, bone mass, and fractures: how are they related? Arthritis Rheum. 2002 Jan;46(1):1-4.
    11. Koh JM, Khang YH, Jung CH, Bae S, Kim DJ, Chung YE, Kim GS. Higher circulating hsCRP levels are associated with lower bone mineral density in healthy pre- and postmenopausal women: evidence for a link between systemic inflammation and osteoporosis. Osteoporos Int. 2005 Oct;16(10):1263-71.
    12. Armour KJ, Armour KE, van’t Hof RJ, Reid DM, Wei XQ, Liew FY, Ralston SH. Activation of the inducible nitric oxide synthase pathway contributes to inflammation-induced osteoporosis by suppressing bone formation and causing osteoblast apoptosis. Arthritis Rheum. 2001 Dec;44(12):2790-6.
    13. Yun AJ, Lee PY. Maldaptation of the link between inflammation and bone turnover may be a key determinant of osteoporosis. Med Hypotheses. 2004;63(3):532-7.
    14. Bai P, Sun Y, Jin J, Hou J, Li R, Zhang Q, Wang Y. Disturbance of the OPG/RANK/RANKL pathway and systemic inflammation in COPD patients with emphysema and osteoporosis. Respir Res. 2011 Dec 16;12:157.
    15. Liang B, Feng Y. The association of low bone mineral density with systemic inflammation in clinically stable COPD. Endocrine. 2011 Dec 24.
    16. Nazrun AS, Norazlina M, Norliza M, Nirwana SI. The anti-inflammatory role of vitamin E in prevention of osteoporosis. Adv Pharmacol Sci. 2012;2012:142702.
    17. García-Hernández A, Arzate H, Gil-Chavarría I, Rojo R, Moreno-Fierros L. High glucose concentrations alter the biomineralization process in human osteoblastic cells. Bone. 2012 Jan;50(1):276-88.
    18. Arends S, Spoorenberg A, Bruyn GA, Houtman PM, Leijsma MK, Kallenberg CG, Brouwer E, van der Veer E. The relation between bone mineral density, bone turnover markers, and vitamin D status in ankylosing spondylitis patients with active disease: a cross-sectional analysis. Osteoporos Int. 2011 May;22(5):1431-9.
    19. Clarenbach CF, Thurnheer R, Kohler M. Vascular dysfunction in chronic obstructive pulmonary disease: current evidence and perspectives. Expert Rev Respir Med. 2012 Feb;6(1):37-43.
    20. Silverman NE, Nicklas BJ, Ryan AS. Addition of aerobic exercise to a weight loss program increases BMD, with an associated reduction in inflammation in overweight postmenopausal women. Calcif Tissue Int. 2009 Apr;84(4):257-65.
    21. Arnott JA, Lambi AG, Mundy C, Hendesi H, Pixley RA, Owen TA, Safadi FF, Popoff SN. The role of connective tissue growth factor (CTGF/CCN2) in skeletogenesis. Crit Rev Eukaryot Gene Expr. 2011;21(1):43-69.
    22. Moussad EE, Brigstock DR. Connective tissue growth factor: what’s in a name? Mol Genet Metab. 2000 Sep-Oct;71(1-2):276-92.
    23. Rosen V. BMP and BMP inhibitors in bone. Ann N Y Acad Sci. 2006 Apr;1068:19-25.
    24. Xu YF, Wan JX, Jiang DW. [Effects of bone morphogenic protein-7 on transdifferentiation and the expression of connective tissue growth factor of human renal tubular epithelial cells induced by transforming growth factor-beta1]. Zhonghua Yi Xue Za Zhi. 2009 Jun 16;89(23):1639-44.
    25. Takahashi T, Muneta T, Tsuji K, Sekiya I. BMP-7 inhibits cartilage degeneration through suppression of inflammation in rat zymosan-induced arthritis. Cell Tissue Res. 2011 May;344(2):321-32.
    26. Santos A, Bakker AD, Willems HM, Bravenboer N, Bronckers AL, Klein-Nulend J. Mechanical loading stimulates BMP7, but not BMP2, production by osteocytes. Calcif Tissue Int. 2011 Oct;89(4):318-26. doi: 10.1007/s00223-011-9521-1.
    27. Kang YH, Jin JS, Yi DW, Son SM. Bone morphogenetic protein-7 inhibits vascular calcification induced by high vitamin D in mice. Tohoku J Exp Med. 2010;221(4):299-307.
    28. Nyman JS, Lynch CC, Perrien DS, Thiolloy S, O’Quinn EC, Patil CA, Bi X, Pharr GM, Mahadevan-Jansen A, Mundy GR. Differential effects between the loss of MMP-2 and MMP-9 on structural and tissue-level properties of bone. J Bone Miner Res.2011 Jun;26(6):1252-60.
    29. Aoki M, Ishigami S, Uenosono Y, Arigami T, Uchikado Y, Kita Y, Kurahara H, Matsumoto M, Ueno S, Natsugoe S. Expression of BMP-7 in human gastric cancer and its clinical significance. Br J Cancer. 2011 Feb 15;104(4):714-8.
    30. Braig S, Wallner S, Junglas B, Fuchshofer R, Bosserhoff AK. CTGF is overexpressed in malignant melanoma and promotes cell invasion and migration. Br J Cancer. 2011 Jul 12;105(2):231-8.
    31. Ehnert S, Baur J, Schmitt A, Neumaier M, Lucke M, Dooley S, Vester H, Wildemann B, Stöckle U, Nussler AK. TGF-β1 as possible link between loss of bone mineral density and chronic inflammation. PLoS One. 2010 Nov 22;5(11):e14073. 1
    32. Johnson RW, Nguyen MP, Padalecki SS, Grubbs BG, Merkel AR, Oyajobi BO, Matrisian LM, Mundy GR, Sterling JA. TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling. Cancer Res. 2011 Feb 1;71(3):822-31.
    33. Jones D, Glimcher LH, Aliprantis AO. Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection. J Clin Invest. 2011 Jul 1;121(7):2534-42. doi: 10.1172/JCI46262.
    34. Lencel P, Magne D. Inflammaging: the driving force in osteoporosis? Med Hypotheses. 2011 Mar;76(3):317-21.
    35. Mundy GR. Osteoporosis and inflammation. Nutr Rev. 2007 Dec;65(12 Pt 2):S147-51.
    36. Lacativa PG, Farias ML. Osteoporosis and inflammation. Arq Bras Endocrinol Metabol. 2010 Mar;54(2):123-32.
    37. Frassetto LA, Todd KM, Morris RC Jr, Sebastian A. Worldwide incidence of hip fracture in elderly women: relation to consumption of animal and vegetable foods. J Gerontol A Biol Sci Med Sci. 2000 Oct;55(10):M585-92.
    38. Abelow BJ, Holford TR, Insogna KL. Cross-cultural association between dietary animal protein and hip fracture: a hypothesis. Calcif Tissue Int. 1992. Jan;50(1):14-8.
    39. Sellmeyer DE, Stone KL, Sebastian A, Cummings SR. A high ratio of dietary animal to vegetable protein increases the rate of bone loss and the risk of fracture in postmenopausal women. Study of Osteoporotic Fractures Research Group. Am J Clin Nutr. 2001 Jan;73(1):118-22.
    40. Frassetto L, Morris RC Jr, Sellmeyer DE, Todd K, Sebastian A. Diet, evolution and aging—the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet. Eur J Nutr. 2001 Oct;40(5):200-13.
    41. Mager DR, Qiao J, Turner J. Vitamin D and K status influences bone mineral density and bone accrual in children and adolescents with celiac disease. Eur J Clin Nutr. 2011 Oct 5. doi: 10.1038/ejcn.2011.176.
    42. Iwamoto I, Kosha S, Noguchi S, Murakami M, Fujino T, Douchi T, Nagata Y. A longitudinal study of the effect of vitamin K2 on bone mineral density in postmenopausal women a comparative study with vitamin D3 and estrogen-progestin therapy. Maturitas. 1999 Jan 4;31(2):161-4.
    43. Iwamoto J, Sato Y, Takeda T, Matsumoto H. High-dose vitamin K supplementation reduces fracture incidence in postmenopausal women: a review of the literature. Nutr Res. 2009 Apr;29(4):221-8.
    44. Apalset EM, Gjesdal CG, Eide GE, Tell GS. Intake of vitamin K1 and K2 and risk of hip fractures: The Hordaland Health Study. Bone. 2011 Nov;49(5):990-5.
    45. Thomas T. [New actors in bone remodelling: a role for the immune system]. Bull Acad Natl Med. 2010 Nov;194(8):1493-503; discussion 1503-4.
    46. Lappe J, Kunz I, Bendik I, Prudence K, Weber P, Recker R, Heaney RP. Effect of a combination of genistein, polyunsaturated fatty acids and vitamins D3 and K1 on bone mineral density in postmenopausal women: a randomized, placebo-controlled, double-blind pilot study. Eur J Nutr. 2012 Feb 3.
    47. Blum SC, Heaton SN, Bowman BM, Hegsted M, Miller SC. Dietary soy protein maintains some indices of bone mineral density and bone formation in aged ovariectomized rats. J Nutr. 2003 May;133(5):1244-9.
    48. Mihalache G, Mihalache GD, Indrei LL, Indrei A, Hegsted M. [Phytoestrogens role in bone functional structure protection in the ovariectomized rat]. Rev Med Chir Soc Med Nat Iasi. 2002 Jan-Mar;106(1):89-92.
    49. Guthrie JR, Ball M, Murkies A, Dennerstein L. Dietary phytoestrogen intake in mid-life Australian-born women: relationship to health variables. Climacteric. 2000 Dec;3(4):254-61.
    50. Nizar AM, Nazrun AS, Norazlina M, Norliza M, Ima Nirwana S. Low dose of tocotrienols protects osteoblasts against oxidative stress. Clin Ter. 2011 Nov;162(6):533-8.
    51. Norazlina M, Lee PL, Lukman HI, Nazrun AS, Ima-Nirwana S. Effects of vitamin E supplementation on bone metabolism in nicotine-treated rats. Singapore Med J. 2007 Mar;48(3):195-9.
    52. Grimm T, Chovanová Z, Muchová J, Sumegová K, Liptáková A, Duracková Z, Högger P. Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol). J Inflamm (Lond). 2006 Jan 27;3:1.
    53. Belcaro G, Cesarone MR, Errichi S, Zulli C, Errichi BM, Vinciguerra G, Ledda A, Di Renzo A, Stuard S, Dugall M, Pellegrini L, Gizzi G, Ippolito E, Ricci A, Cacchio M, Cipollone G, Ruffini I, Fano F, Hosoi M, Rohdewald P. Variations in C-reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pycnogenol. Redox Rep. 2008;13(6):271-6.
    54. Hwang YC, Jeong IK, Ahn KJ, Chung HY. The effects of Acanthopanax senticosus extract on bone turnover and bone mineral density in Korean postmenopausal women. J Bone Miner Metab. 2009;27(5):584-90.
     
    Related Searches
    • Fermented
    • Calcium
    • Multivitamins
    • Children
    Related Knowledge Center
    • Dietary Supplements
    • Green Foods
    • Inflammation
    Suggested For You
    Brain Health: A Mysterious Frontier Brain Health: A Mysterious Frontier
    Gencor Introduces Water-Dispersible Version of Veri-te Resveratrol Gencor Introduces Water-Dispersible Version of Veri-te Resveratrol
    Rat Study Shows High Doses of Alpha Tocopherols Don’t Lead to Bone Loss Rat Study Shows High Doses of Alpha Tocopherols Don’t Lead to Bone Loss
    Branded Ingredient Showcase Branded Ingredient Showcase
    Skeleton Crew: Solutions for Bone Health Skeleton Crew: Solutions for Bone Health
    Rousselot to Showcase Peptan Collagen Range Rousselot to Showcase Peptan Collagen Range
    DSM Launches 3C Technology for Omega-3 Supplements DSM Launches 3C Technology for Omega-3 Supplements
    ExcelVite to Present Unique Health Benefits of Plant-Derived Beta-Carotene ExcelVite to Present Unique Health Benefits of Plant-Derived Beta-Carotene
    Nutrition: Essential, Yet Dismissed & Overlooked Nutrition: Essential, Yet Dismissed & Overlooked
    Adopting Electioneering Tactics to Eradicate Micronutrient Inadequacies Adopting Electioneering Tactics to Eradicate Micronutrient Inadequacies
    Healthy Aging Healthy Aging
    Strengthening the Bone Health Market Strengthening the Bone Health Market
    OptiMSM K-Blend OptiMSM K-Blend
     Vitamin K Vitamin K
    Vitamin K Vitamin K

    Related Features

    • Antioxidants | Contract Manufacturing | Fiber & Carbohydrates | Herbs & Botanicals | Marine Nutraceuticals | Minerals | Omega-3s | Probiotics & Prebiotics | Proteins, Peptides, Amino Acids | Vitamins
      2021 International Buyers

      2021 International Buyers' Guide

      An annual reference of companies supplying nutraceutical ingredients, products, and services around the world.
      Compiled by Nutraceuticals World Staff 12.04.20

    • Dietary Supplements | Healthcare Trends | Quality & Safety | Regulations
      State of the Industry: Positive Market Outlook Despite COVID-19 Turmoil

      State of the Industry: Positive Market Outlook Despite COVID-19 Turmoil

      Third annual survey reveals gains for businesses as consumers focus on health and wellness, but supply chain disruptions cause concern.
      By Sean Moloughney, Editor 12.04.20

    • Cognitive Function | Dietary Supplements | Healthcare Trends | Healthy Aging | Herbs & Botanicals | Minerals | Mood Health & Sleep | Omega-3s | Proteins, Peptides, Amino Acids | Vitamins
      Brain Health: A Mysterious Frontier

      Brain Health: A Mysterious Frontier

      Despite many unknowns, nutrition has a clear role in protecting and optimizing the most critical organ at every life stage.
      By Mike Montemarano, Associate Editor 12.04.20


    • Functional Foods & Beverages | Green Foods | Immune Function | Mood Health & Sleep | Proteins, Peptides, Amino Acids
      Key Trends in Functional Foods & Beverages for 2021

      Key Trends in Functional Foods & Beverages for 2021

      If you want to succeed in the business of food and health, reinventing traditional foods will give you the greatest chance of success, as it has done for years.
      By Julian Mellentin, Director, New Nutrition Business 11.09.20

    • Consumer Trends | Dietary Supplements | Healthcare Trends | Quality & Safety | Sports Nutrition
      How Sports Nutrition is Adapting to COVID-19 Upheaval

      How Sports Nutrition is Adapting to COVID-19 Upheaval

      Experts specializing in fitness, dietary supplements, and third-party testing discussed where they see the industry headed.
      By Mike Montemarano, Associate Editor 11.09.20

    • Fatty Acids | Herbs & Botanicals | Immune Function | Men's Health | Mood Health & Sleep | Research | Women's Health
      A Health Gap: Disparity in Immunity & Well-Being in 2020

      A Health Gap: Disparity in Immunity & Well-Being in 2020

      Men face greater health risks from COVID-19, likely due to a combination of biological, behavioral, and psychosocial factors.
      By Maggie McNamara, Marketing Director, Gencor 11.09.20


    • Herbs & Botanicals | Immune Function | Quality & Safety | Research
      Black Elderberry: A New Age of Science & Quality

      Black Elderberry: A New Age of Science & Quality

      With support from clinical findings and increased consumer demand, elderberry is a top ingredient in the dietary supplement and natural products industry.
      By Melanie Bush, Director of Science, Artemis International, Inc. 10.01.20

    • Delivery & Dosage Technologies | Immune Function | Minerals | Vitamins
      Key Immune Health Ingredients & A Unique Delivery System

      Key Immune Health Ingredients & A Unique Delivery System

      Oral Thin Film Strip Melts work particularly well with popular ingredients like vitamins D3, K2, and zinc.
      By John G. Tobin, President/CEO NutraFood Science Delivery System, Inc. 10.01.20

    • Cardiovascular Health | Fatty Acids | Marine Nutraceuticals | Omega-3s | Research
      Groundbreaking Study Links Omega-3 EPA & DHA Dosage to Positive Cardiovascular Outcomes

      Groundbreaking Study Links Omega-3 EPA & DHA Dosage to Positive Cardiovascular Outcomes

      Comprehensive meta-analysis helps clear up confusion on contradictory omega-3 research.
      By Chris Gearheart, Director – Member Communications and Engagement, GOED (Global Organization for EPA & DHA Omega-3s) 10.01.20


    • Diabetes & Blood Sugar Management | Fiber & Carbohydrates | Healthcare Trends | Research
      Metabolic Health: It’s All About Insulin

      Metabolic Health: It’s All About Insulin

      Products for metabolic and glycemic health will constitute a huge market segment for decades to come.
      By Rhonda Witwer, Executive Director of www.ResistantStarchResearch.com., and Amy Gilliland, Business Development Manager and Food Scientist 10.01.20

    • Herbs & Botanicals | Immune Function | Research
      Mushrooms: Immune Support Workhorses

      Mushrooms: Immune Support Workhorses

      Fungi-based supplements fit well in a true healthcare model founded in prevention.
      By David Law, President & CEO, Gourmet Mushrooms, Inc 10.01.20

    • Delivery & Dosage Technologies | Dietary Supplements | Immune Function | Minerals | Products | Vitamins
      Nature Made Launches ImmuneMax Fizzy Drink Mix

      Nature Made Launches ImmuneMax Fizzy Drink Mix

      Powdered drink mix delivers 2,000 mg of vitamin C, 25 mcg of vitamin D, and 20 mg of zinc per stick pack.
      By Sean Moloughney, Editor 10.01.20


    • Cardiovascular Health | Consumer Trends | Diabetes & Blood Sugar Management | Dietary Supplements | Healthcare Trends | Herbs & Botanicals | Proteins, Peptides, Amino Acids | Quality & Safety | Weight Management/Weight Loss
      The Big Picture: Weight Wellness Trends

      The Big Picture: Weight Wellness Trends

      Consumers continue to tip the scales at a time when health hangs in the balance.
      By Sean Moloughney, Editor 09.08.20

    • Herbs & Botanicals | Minerals | Mood Health & Sleep | Probiotics & Prebiotics | Proteins, Peptides, Amino Acids | Vitamins
      Mood in the Time of COVID-19

      Mood in the Time of COVID-19

      In turbulent times, natural products are more sought-after than ever before by the stressed and the sleepless.
      By Mike Montemarano, Associate Editor 09.08.20

    • Consumer Trends | Healthcare Trends | Herbs & Botanicals | Mood Health & Sleep | Research
      Botanicals for Managing Stress Naturally: Leveraging Wisdom and Science from Plants

      Botanicals for Managing Stress Naturally: Leveraging Wisdom and Science from Plants

      Scientific evidence indicates herbal supplements can play a role in managing the effects of modern living.
      By James Roza, Chief Science Advisor, Layn Natural Ingredients-USA 09.08.20

    Trending
    • Preliminary Study Suggests Link Between Omega-3s And Lower COVID-19 Death Rates
    • Dietary Fiber Intake Associated With Lower Risk For Depression In Premenopausal Women
    • NSF Begins New Certification Program
    • ConsumerLab Tests: Collagen Supplements Meet Label Claims
    • DuPont Introduces HOWARU, A Probiotic Formulated For Stress
    Breaking News
    • Brown Fat Associated with Reductions in Chronic Disease Risk
    • NIH Study Identifies Antibacterial Properties in Taurine
    • NSF Begins New Certification Program
    • Eriocitrin Shown to Have Metabolic Benefits in Recent Study
    • EverGrain Introduces Sustainable Barley Ingredients
    View Breaking News >
    CURRENT ISSUE

    December 2020

    • 2021 International Buyers' Guide
    • State of the Industry: Positive Market Outlook Despite COVID-19 Turmoil
    • Brain Health: A Mysterious Frontier
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Brown Fat Associated with Reductions in Chronic Disease Risk
    NIH Study Identifies Antibacterial Properties in Taurine
    NSF Begins New Certification Program
    Coatings World

    Latest Breaking News From Coatings World

    Zeppelin Acquires MTI Mischtechnik
    Ezio Braggio Joins ChemQuest Europe
    IFS Coatings Announce Carbon Offset Program
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    Optimize EP Launches CaRM Cardiac Device Data Management Platform
    U.S. TAVR Market Projected to Reach Nearly $5 Billion by 2030
    FDA Clears Canon Medical's Compressed SPEEDER for 3D Exams on 1.5T MR
    Contract Pharma

    Latest Breaking News From Contract Pharma

    KORSCH, MEDELPHARM Partner on R&D Equipment Portfolio
    Frontage Bolsters Clinical Services Capabilities
    Sanofi Unveils EUROAPI as Name of New European API Company
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Neenah to Host Packaging Webinar for Printers
    W.S. Badger is Named a ‘150 Top Impact Company’
    Mana Products, Meiyume and RPG Form The Vertical Beauty Alliance
    Happi

    Latest Breaking News From Happi

    A Surge in Interest for Supplements & Vitamins
    P&G, L'Oréal & Amorepacific Make News at CES
    Three Form Vertical Beauty Alliance
    Ink World

    Latest Breaking News From Ink World

    dar-tech, inc. Becomes U.S. Midwestern Distributor for ZS Interpolymer
    Techkon USA, Konica Minolta Partner
    Alon Bar-Shany Appointed Chairman of Highcon Board
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    Exhibitor registration opens for virtual.drupa
    FTA planning in-person Forum & INFOFLEX
    Fortis Solutions Group achieves SGP certification
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Shemesh Adds U.S. Headquarters
    TZMO USA, Special Needs Group Form Partnership
    BAHP Announces 2021 Officers, Board of Directors
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    Rapid Recovery Protocol Can Lead to Increased Range of Motion After TKA
    Boston Scientific Releases WaveWriter Alpha Spinal Cord Stimulators in U.S.
    New Chief Clinical Officer on Board at IncludeHealth
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Roadsimple Modernizes Warehouse Ops with Zebra Technologies
    Toppan Announces 2050 Environmental Vision
    SOI Industry Consortium Joins SEMI as Strategic Association Partner

    Copyright © 2021 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login