01.09.12
A new research study on NEM (Natural Eggshell Membrane) ESM Technologies has been published in the Journal of Medicinal Food. This new mechanism of action research was conducted to gain insight into NEM’s clinical efficacy in reducing joint pain and stiffness.
Kevin Ruff, PhD, MBA, director of scientific and regulatory affairs for ESM Technologies, said “When human immune cells were exposed to a water extract of NEM and subsequently compounds that are known to cause an inflammatory response, NEM was shown to significantly reduce a number of pro-inflammatory cytokines.”
This effect was most pronounced for the cytokines Interferon-gamma (IFN-g) and Tumor Necrosis Factor-alpha (TNF-α). The reduction in TNF-α was further enhanced by a simulated gastric digestion, likely giving insight into the compounds produced in the stomach following digestion of NEM. TNF-α plays an important role in inflammatory processes, particularly chronic joint inflammation. Dr. Ruff concludes, “This preliminary work demonstrates that NEM’s ability to reduce joint pain and stiffness may well be a result of its ability to reduce TNF-α systemically or locally in the joints.”
The bioactivity of NEM was compared to a digested sample of the same product/lot. The digestion mimicked specific phases of the human digestive processes (acid/pepsin, followed by bile enzymes and salts) and was performed using an in vitro digest protocol at NIS Labs. The testing was performed to examine whether the biological properties of NEM were preserved or enhanced after digestion. The data showed that specific anti-inflammatory properties were enhanced after the in vitro digest. Where the crude product suppressed the inflammatory cytokine TNF-alpha production in cultures of human immune cells, the NEM after an in vitro digest produced similar effect at 100 times lower doses, suggesting stronger anti-inflammatory effects after digestion. For further information: www.esmingredients.com
Kevin Ruff, PhD, MBA, director of scientific and regulatory affairs for ESM Technologies, said “When human immune cells were exposed to a water extract of NEM and subsequently compounds that are known to cause an inflammatory response, NEM was shown to significantly reduce a number of pro-inflammatory cytokines.”
This effect was most pronounced for the cytokines Interferon-gamma (IFN-g) and Tumor Necrosis Factor-alpha (TNF-α). The reduction in TNF-α was further enhanced by a simulated gastric digestion, likely giving insight into the compounds produced in the stomach following digestion of NEM. TNF-α plays an important role in inflammatory processes, particularly chronic joint inflammation. Dr. Ruff concludes, “This preliminary work demonstrates that NEM’s ability to reduce joint pain and stiffness may well be a result of its ability to reduce TNF-α systemically or locally in the joints.”
The bioactivity of NEM was compared to a digested sample of the same product/lot. The digestion mimicked specific phases of the human digestive processes (acid/pepsin, followed by bile enzymes and salts) and was performed using an in vitro digest protocol at NIS Labs. The testing was performed to examine whether the biological properties of NEM were preserved or enhanced after digestion. The data showed that specific anti-inflammatory properties were enhanced after the in vitro digest. Where the crude product suppressed the inflammatory cytokine TNF-alpha production in cultures of human immune cells, the NEM after an in vitro digest produced similar effect at 100 times lower doses, suggesting stronger anti-inflammatory effects after digestion. For further information: www.esmingredients.com