This research confirmed that not all beta-glucans are alike. Led by David Underhill, PhD, researchers demonstrated that beta-glucan size and molecular structure is critical to receptor binding and the resulting innate immune cell response. Dr. Underhill and his research team found that specific beta-glucan structures bind to a particular receptor (Dectin-1) while other beta-glucans structures may not.
The study shows that Dectin-1 distinguishes between direct microbial contact and detection of microbes at a distance, a distinction that enables effective microbial killing responses. When bound to Biothera’s Wellmune WGP, Dectin-1 signaling primed immune cells for phagocytosis, a mechanism used to recognize and destroy pathogens.
“This research was possible because of Biothera’s capability to isolate, modify and characterize these beta-glucan compounds,” said Dr. Underhill, associate professor, IBD and Immunobiology Research Institute, Cedars-Sinai Medical Center. For further information: www.biothera.com