05.16.11
A review published in Phytotherapy Research provides an in-depth scientific analysis of the chemistry and safety of bitter orange drawn from 89 clinical research studies and other reference sources. The article concludes that the "preponderance of human clinical studies have reported that bitter orange extract (p-synephrine) either alone or in combination with caffeine and other ingredients has no effect on blood pressure or heart rate."
This summary of the most current research and knowledge available on bitter orange contains a detailed discussion of p-synephrine receptor binding and the reasons for the absence of negative cardiovascular side effects. It also reports that 19 separate analytical studies determined that m-synephrine was not present among the protoalkaloids of bitter orange. m-Synephrine (phenylephrine), which is often found in nasal decongestants and sprays, has the potential for raising blood pressure in humans. For further information: www.nutratechinc.com
This summary of the most current research and knowledge available on bitter orange contains a detailed discussion of p-synephrine receptor binding and the reasons for the absence of negative cardiovascular side effects. It also reports that 19 separate analytical studies determined that m-synephrine was not present among the protoalkaloids of bitter orange. m-Synephrine (phenylephrine), which is often found in nasal decongestants and sprays, has the potential for raising blood pressure in humans. For further information: www.nutratechinc.com