09.01.06
Indication: Lowering homocysteine and cognitive performance
Source: New Eng J Med, June 29, 2006;354(26):2764-2772.
Research: Researchers conducted a two-year, double-blind, placebo-controlled, randomized clinical trial involving 276 healthy participants, 65 years of age or older, with plasma homocysteine concentrations of at least 13 μmol per liter. Homocysteine-lowering treatment was a daily supplement containing folate (1000 μg) and vitamins B12 (500 μg) and B6 (10 mg). Tests of cognition were conducted at baseline and after one and two years of treatment.
Results:
On average, during the course of the study, the plasma homocysteine concentration was 4.36 μmol per liter lower in the vitamin group than in the placebo group. Overall there were no significant differences between the vitamin and placebo groups in the scores on tests of cognition. Researchers believe that the results of this trial do not support the hypothesis that homocysteine lowering with B vitamins improves cognitive performance.
Source: New Eng J Med, June 29, 2006;354(26):2764-2772.
Research: Researchers conducted a two-year, double-blind, placebo-controlled, randomized clinical trial involving 276 healthy participants, 65 years of age or older, with plasma homocysteine concentrations of at least 13 μmol per liter. Homocysteine-lowering treatment was a daily supplement containing folate (1000 μg) and vitamins B12 (500 μg) and B6 (10 mg). Tests of cognition were conducted at baseline and after one and two years of treatment.
Results:
On average, during the course of the study, the plasma homocysteine concentration was 4.36 μmol per liter lower in the vitamin group than in the placebo group. Overall there were no significant differences between the vitamin and placebo groups in the scores on tests of cognition. Researchers believe that the results of this trial do not support the hypothesis that homocysteine lowering with B vitamins improves cognitive performance.
