05.01.03
Indication: Bioavailability
Source: J Nutr, 2002;132:3668-3673.
Research: Researchers from the University of Illinois, Chicago, performed a head-to-head comparison of the bioavailability of lutein esters and free (unesterified) lutein. Using a randomized, crossover study design, they gave eight women and 10 men a single dose of either lutein esters or free lutein. The doses were calculated based on the volunteer’s body weight and on the all-trans lutein content of each formulation, so that the same amount of all-trans lutein was delivered in each formulation. The free lutein formulation was a crystalline suspension in safflower oil; the lutein ester formulation was a powder and both formulations were packed into gelatin capsules for administration. Blood samples were taken before administration of the dose and at various intervals afterward. The diet was carefully controlled from two days prior until two days after the dose was given.
Results: The lutein ester supplement resulted in greater bioavailability of lutein, compared with free lutein, in 14 of the 18 subjects. Overall, lutein was 62% more bioavailable from the lutein ester formulation than from the lutein formulation. In addition, lutein from the lutein ester supplement was absorbed faster and resulted in higher blood levels of lutein. During digestion, a normal process known as hydrolysis splits the ester bond, allowing for absorption of lutein and assimilation into the bloodstream, so it can reach tissues.
Source: J Nutr, 2002;132:3668-3673.
Research: Researchers from the University of Illinois, Chicago, performed a head-to-head comparison of the bioavailability of lutein esters and free (unesterified) lutein. Using a randomized, crossover study design, they gave eight women and 10 men a single dose of either lutein esters or free lutein. The doses were calculated based on the volunteer’s body weight and on the all-trans lutein content of each formulation, so that the same amount of all-trans lutein was delivered in each formulation. The free lutein formulation was a crystalline suspension in safflower oil; the lutein ester formulation was a powder and both formulations were packed into gelatin capsules for administration. Blood samples were taken before administration of the dose and at various intervals afterward. The diet was carefully controlled from two days prior until two days after the dose was given.
Results: The lutein ester supplement resulted in greater bioavailability of lutein, compared with free lutein, in 14 of the 18 subjects. Overall, lutein was 62% more bioavailable from the lutein ester formulation than from the lutein formulation. In addition, lutein from the lutein ester supplement was absorbed faster and resulted in higher blood levels of lutein. During digestion, a normal process known as hydrolysis splits the ester bond, allowing for absorption of lutein and assimilation into the bloodstream, so it can reach tissues.
