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The microbiome, proof of benefit, and personalized solutions are top of mind in the market today.
August 21, 2023
By: Sean Moloughney
Editor
The human body consists of trillions of microbial cells. The gastrointestinal (GI) tract in particular contains a diverse community of bacteria that help to regulate digestion while playing an important role in the extraction, synthesis, and absorption of nutrients and metabolites. Research continues to reveal various ways the human microbiome influences physiology, health and wellness states, emotion, and behavior. Market growth is evident as well. The global human microbiome sector is currently valued at about $7 billion, and is expected to reach $9.1 billion by 2026, growing at a CAGR of 8.6% between 2020 and 2026, according to Euromonitor International. The gastrointestinal tract plays a significant role in immune health, with more than 70% of the body’s immune cells contained within the gut-associated lymphoid tissue (GALT). So it’s no wonder that digestive health and the role of the microbiome are increasingly viewed as central to overall wellness. Most of our bacteria reside in the colon, while the skin is the second most-abundant site. More than half (58%) of global consumers are aware of the benefits that bacteria in the digestive system can have on overall health, according to the Hartman Group (October 2021). However, only 14% are familiar with the term “microbiome.” Alongside digestive health (72%), immune health (71%), and healthy aging (71%), top perceived benefits of bacteria in the digestive system include mental/cognitive health (34%), weight management (28%), metabolic health (23%), and skin health (16%). With growing recognition about the connections between mind and body, consumers are paying more attention to the impact their food, beverage, and supplement choices may have on their wellbeing. Research is also uncovering the role of the skin microbiome and how probiotics may support skin health in both oral and topical applications. According to an article published in Frontiers in Microbiology (Salem et al., 2018): “The gut and skin, densely vascularized and richly innervated organs with crucial immune and neuroendocrine roles, are uniquely related in purpose and function. As our primary interface with the external environment, both organs are essential to the maintenance of physiologic homeostasis. Cumulative evidence has demonstrated an intimate, bidirectional connection between the gut and skin, and numerous studies link gastrointestinal (GI) health to skin homeostasis and allostasis. GI disorders are often accompanied by cutaneous manifestations and the GI system, particularly the gut microbiome, appears to participate in the pathophysiology of many inflammatory disorders.” In their review of the gut microbiome as a major regulator of the gut-skin axis, Salem et al. noted that clinical studies have demonstrated the gut microbiome’s contribution to homeostasis, allostasis, and the pathogenesis of disease. “Through complex immune mechanisms, the influence of the gut microbiome extends to involve distant organ systems including the skin. With intentional modulation of the microbiome, probiotics, prebiotics, and synbiotics have proven beneficial in the prevention and/or treatment of inflammatory skin diseases including acne vulgaris, AD (atopic dermatitis), and psoriasis. “In this up-and-coming field,” they continued, “future research should improve our understanding of the complex mechanisms underlying the gut-skin axis, investigate the therapeutic potential of long-term modulation of the gut microbiome, and potentially expand therapeutic manipulation to include commensal gut fungi and viruses in order to fully harness the gut microbiome’s influence in the treatment of skin disease.”
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