Two in depth studies by world renowned Alzheimer research scientist, Dr. Nibaldo Inestrosa, — "Andrographolide activates the canonical Wnt signalling pathway by a mechanism that implicates the non-ATP competitive inhibition of GSK-3β: Auto regulation of GSK-3β in vivo (Tapia-Rojas, C., et al, Biochemical Journal, Nov. 2014), and "Andrographolide reduces cognitive impairment in young and mature AbetaPPswe/PS-1 mice," (Serrano, F., et al, Molecular Neurodegeneration, Dec 2014, 9:61) — have demonstrated that NeuroActin activates both canonical and non-canonical Wnt signaling; inhibits GSK-3β; reduces tau hyperphosphorylation; Induces postsynaptic proteins and synaptic function (LTP); and stimulates neurogenesis.
"These two in-depth studies illuminate the potent and diligent activities as well as the affinity of the Andrographis extract in supporting brain integrity," said Annie Eng, CEO of HP Ingredients. "The genesis of our long-term research and development of NeuroActin was to provide a powerful ingredient to address the desires of millions of active Americans who are concerned with maintaining brain and cognitive fitness well into their futures."
“Andrographolide keeps Tau molecules from collapsing and tangled, reduces oxidative stress and inflammation in the brain,” explained Dr. Juan Hancke, another research scientist in both publications. “Andrographis is used in Traditional Chinese Medicine and Ayurvedic to balance insulin. Even though the in vitro and in vivo research is not showing much effects on beta-amyloid, APP Alzheimer modeled mice treated with Andrographolide are able to find the escape platform in the water maze experiment as quickly as normal mice.” The next step is to conduct human clinical to confirm the findings in the in vitro and in vivo study.
These two in-depth studies have found NeuroActin to promote integrity of brain structure and function, and can help stimulate keener learning and memory, thereby providing consumers with confidence in protecting the health of their brain and cognition as they age.
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