The triple-blind, dose-response study concluded that the four-strain probiotic combination in HOWARU Restore appears to lower the risk and duration of antibiotic-associated diarrhea (AAD). A decrease in gastrointestinal symptoms —fever, bloating and abdominal pain — also was observed compared to the placebo group.
The 503 adult subjects were divided into three groups: a placebo group and two groups that received either a low dose or high dose of HOWARU Restore. Both probiotic treatments and the placebo were administered daily in the form of capsules during and for seven days following antibiotic treatment.
While the low-dose group clearly experienced fewer antibiotic side effects than the placebo group, the incidence of AAD in the high-dose group was, at 12.5%, close to half that of the placebo group (24.6%). The high-dose group similarly had a considerably lower rate of fever and gastrointestinal discomfort.
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