02.22.08
Indication: Physical decline (elderly)
Source: JAMA, January 2008;23;299(3):308-15.
Research: Maintaining independence of older persons is a public health priority, and identifying the factors that contribute to decline in physical function is needed to prevent or postpone the disablement process. The potential deleterious effect of poor nutrition on decline in physical function in older persons is unclear, so researchers set out to determine whether a low serum concentration of micronutrients is associated with subsequent decline in physical function among older men and women living in the community. This longitudinal study evaluated 698 community-living persons 65 years or older who were randomly selected from a population registry in Tuscany, Italy. Researchers measured their levels of several micronutrients, including serum folate and vitamins E, D, B6 and B12. Researchers then measured decline in physical function, as defined by a loss of at least one point in the Short Physical Performance Battery.
Results: The results provided empirical evidence showing that a low serum concentration of vitamin E is associated with subsequent decline in physical function, as brought on by oxidative stress, a situation that induces muscle fatigue. Clinical trials may be warranted to determine whether an optimal concentration of vitamin E reduces functional decline and the onset of disability in older persons.