Indication: Multiple organ dysfunction syndrome (MODS)
Source:Am J Clin Nutr, March 2007;85(3):816-23.
Research: Multiple organ dysfunction syndrome (MODS) is a major cause of mortality in intensive care units. A breakdown in gut barrier function and immune dysfunction are associated with the onset of MODS. Probiotic bacteria have been shown to modulate intestinal barrier and immune function. This study sought to determine the efficacy of a probiotic compound in a viable and nonviable formulation in modulating intestinal permeability and immune function and preventing the onset of MODS in patients in an intensive care unit. A double-blind, randomized, controlled trial was conducted in the intensive care unit of a tertiary care teaching hospital. Twenty-eight critically ill patients admitted to the intensive care unit were randomly assigned to receive 1 of 3 treatments daily for 7 days: 1) placebo, 2) viable probiotics, or 3) equivalent probiotic sonicates. MODS scores and systemic concentrations of immunoglobulin (Ig) A and IgG were measured on days -1, 4, and 7, and intestinal permeability measurements were taken daily.
Results: The patients responded to viable probiotics with a significantly larger increase in systemic IgA and IgG concentrations than in the patients who received placebo or sonicates. MODS scores, however, were not significantly affected by probiotic treatment. Over the study period, intestinal permeability decreased in most patients. Researchers said patients receiving viable probiotics showed a greater enhancement in immune activity than patients receiving either placebo or probiotic bacterial sonicates.