• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Nutraceuticals for Men: Muscle Health and Performance Nutrition

    Aging in Place: Healthy Lifestyles Supplement Science-Based Solutions

    Getting an Edge in Esports: Meeting the Health Needs of Competitive Gamers

    Beyond CBD: Cannabis Compounds Warrant Recognition and More Research

    Leveling Out the Energy Segment for Mainstream, and Rethinking Caffeine
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    GOED Creates Infographic Highlighting Omega-3 Health Claims Approved in Europe

    Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board

    Expert Consensus Statement: Diet is Best Primary Intervention to Achieve Diabetes Remission

    Choline Alone May Improve Maternal DHA Status During Pregnancy

    Cranberry Consumption Linked to Memory and Neurological Function Improvements
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    GOED Creates Infographic Highlighting Omega-3 Health Claims Approved in Europe

    Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board

    Choline Alone May Improve Maternal DHA Status During Pregnancy

    Cranberry Consumption Linked to Memory and Neurological Function Improvements

    Bilberon Bilberry Extract Receives U.S. Patent For Eye Strain, Neck/Shoulder Pain
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    FDA Issues Draft Guidance on NDI Enforcement Discretion

    GOED Creates Infographic Highlighting Omega-3 Health Claims Approved in Europe

    Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board

    Expert Consensus Statement: Diet is Best Primary Intervention to Achieve Diabetes Remission

    Choline Alone May Improve Maternal DHA Status During Pregnancy
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board

    Expert Consensus Statement: Diet is Best Primary Intervention to Achieve Diabetes Remission

    Choline Alone May Improve Maternal DHA Status During Pregnancy

    Cranberry Consumption Linked to Memory and Neurological Function Improvements

    Bilberon Bilberry Extract Receives U.S. Patent For Eye Strain, Neck/Shoulder Pain
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    ESHA Research

    Sabinsa Corporation

    Botanic Healthcare LLC

    Ecuadorian Rainforest

    Applied Food Sciences, Inc.
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    ESHA Research

    Sabinsa Corporation

    Botanic Healthcare LLC

    Ecuadorian Rainforest

    Applied Food Sciences, Inc.
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Online Exclusives

    New Pathways for Menopause Relief

    Metagenics’ Siberian rhubarb extract proven to alleviate common symptoms and ease link between menopause and the development of chronic illness.

    Related CONTENT
    • The Immunity Imperative
    • NSF International Launches Raised Without Antibiotics Certification
    • Dietary Potassium Linked with Lower Blood Pressure
    • Getting to the Heart of Cardiovascular Health
    • Getting Ahead of the Curve: Global Nutraceutical Hot Spots
    Joanna Cosgrove, Online Editor08.20.12
    The World Health Organization has estimated that 1.1 billion women worldwide will be transitioning into menopause by 2025. It’s also been estimated that up to 70% of women experience menopause symptoms, which can occur five to ten years prior menopause, during a period called peri-menopause. The link between menopause and the development of chronic disease has been the subject of much research and was at the center of a recent webinar hosted by Deanna Minich, PhD, FACN, CNS, vice president of scientific affairs at Metagenics.
     
    Dr. Minich presented clinical research supporting the use of Estrovera™ dietary supplement (ERr 731) to help combat the symptoms of menopause. Although hot flushes and night sweats might seem like minor annoyances to some, these vasomotor symptoms, coupled with other symptoms such as exhaustion, mood imbalance, sleep problems, heart discomfort, urogenital problems and joint/muscle problems make women more susceptible to major health problems because the loss of estrogen can critically impact the  brain, the heart, breasts, liver, uterus and bones.
     
    “Women are more prone to chronic disease onset during the menopausal transition, like osteoporosis and bone fragility, cardiovascular disease, increased rates of diabetes and metabolic syndrome, and inflammation in the body,” said Dr. Minich. “Anxiety and depression are also more apparent. If you talk to women during this time in their lives, they say that they just don’t feel like themselves anymore.”
     
    The standard of care is typically hormone therapy but while its benefits include improved vasomotor symptoms, reduced risks of colorectal cancer, bone related challenges and coronary heart issues, there are risks related to breast tissue, endometrial and cardiovascular health; altered mood, and cognitive effects. And those risks have been enough for women to seek alternative solutions that include avoiding or minimizing caffeine and alcohol, getting seven to eight hours of sleep per night, breathing exercises, consuming low-glycemic foods, getting regular exercise, and staying hydrated.
     
    Dr. Minich added that consuming the right nutrients can have a beneficial impact. Natural approaches—such as soy/clover isoflavones, hops, flax lignans or black cohosh—may offer a higher degree of safety for both peri- and postmenopausal use, but have shown a varying degree of clinical success and lack adequate scientific support that demonstrates a high degree of efficacy.  “Phytonutrients play a huge role in helping the cell to communicate better and help with genomic stability,” she said, spotlighting probiotics, minerals (calcium and magnesium), vitamin D, fish oil and medical foods that include specific targeted nutrients.
     
    One such nutrient, she said, was ERr 731, an extract of Siberian rhubarb – not the typical garden variety plant but one introduced from Asia to Europe, where it is now cultivated. Its beneficial constituents are rhaponticin, desoxyrhaponticin, rhapontigenin and desoxyrhapontigenin – all of which are natural hydroxystilbenes.
     
    ERr 731 is an estrogen receptor (ER)-beta agonist and Dr. Minich explained that it does not contain estrogen or impact blood estrogen levels. “It weakly stimulates the receptor in the body between 18-31 times more than genestein (a soy isoflavone),” she said. “A study published in the Journal of Steroid Biochemistry & Molecular Biology stated that ‘since the ER-beta is a negative regulator of ER-alpha, it may play an important role for preventing menopause associated symptoms such as depression, anxiety and hot flushes, and may offer protection to some degree from inflammation, hyperplasia and cancer.’”
     
    She went on to talk about how in a 12 week study of 109 perimenopausal women, ERr 731 reduced the number of hot flashes from 12 per day to 1.5 per day on average in 12 weeks. It’s also been studied in relation to menopausal anxiety, prior to launch by Metagenics.
     
    “Multiple in vitro and in vivo studies for toxicology and metabolism demonstrated a high degree of predicted safety,” Dr. Minich reported. “No clinical relevant changes in safety parameters including gynecological findings, vital parameters and laboratory safety parameters [were] associated with treatment after 108 weeks of clinical observation.”

    Its taste and tolerance was also studied at Metagenics’ own Functional Medicine Research Center. A total of 18 participants tolerated ERr 731 well and all three subscales (psychological, somatic and urogenital symptoms) were “significantly improved” after four weeks of ERr 731 intervention (4mg per day).

    “In total, the product is supported by five published human clinical studies that have tested a cumulative total of 400 women, all of which observed a reduction in menopausal symptoms within about 28 days compared to placebo,” commented Dr. Minich.

    A 12-week trial coupled with Metagenics’ UltraMeal® Plus 360 medicinal food yielded even more comprehensive results related to cholesterol and homosysteine levels. The product also demonstrated increased benefits to bone matrix health, as well as improvements in markers of urogenital health.

    “Women are looking for natural, safe therapeutics to manage their menopausal symptoms [and] targeted nutrients can have nutrigenomics-based effects in the body, resulting in a more balanced physiology,” concluded Dr. Minich. “ERr 731 has been shown to be effective for reducing a spectrum of menopausal systems, and at parity with low dose hormone therapy in quelling hot flushes. Adjunctive nutritional support can also include specific phytonutrients, fish oil, and vitamin D, to name a few.”

    For more information about Estrova ERr 731, click this link.
     
    Related Searches
    • Calcium
    • Bones
    • Health
    • Menopause
    Related Knowledge Center
    • Immune Function
    • Functional Foods & Beverages
    • Dietary Supplements
    Suggested For You
    The Immunity Imperative The Immunity Imperative
    NSF International Launches Raised Without Antibiotics Certification NSF International Launches Raised Without Antibiotics Certification
    Dietary Potassium Linked with Lower Blood Pressure Dietary Potassium Linked with Lower Blood Pressure
    Getting to the Heart of Cardiovascular Health Getting to the Heart of Cardiovascular Health
    Getting Ahead of the Curve: Global Nutraceutical Hot Spots Getting Ahead of the Curve: Global Nutraceutical Hot Spots
    Industry Attorney Robert Ullman Remembered Industry Attorney Robert Ullman Remembered
    UNPA to Host Personalized Medicine Seminar UNPA to Host Personalized Medicine Seminar
    Convergence of the Health Practitioner Channel & Medical Foods Convergence of the Health Practitioner Channel & Medical Foods
    Lyc-O-Fem Treats Menopause Symptoms & Supports Bone Health Lyc-O-Fem Treats Menopause Symptoms & Supports Bone Health
    The Future of Medical Foods The Future of Medical Foods
    Metagenics Acquires Bariatric Advantage Maker Metagenics Acquires Bariatric Advantage Maker
    Estrovera Relieves Hot Flashes and Other Menopausal Symptoms Estrovera Relieves Hot Flashes and Other Menopausal Symptoms
    Alticor Obtains Ownership in Metagenics Alticor Obtains Ownership in Metagenics
    Solbar Enters Cosmeceuticals Market Solbar Enters Cosmeceuticals Market
    Health Strategy Spotlight: Case Study: Metagenics Health Strategy Spotlight: Case Study: Metagenics

    Related Content

    • Antioxidants | Consumer Trends | Dietary Supplements | Healthcare Trends | Herbs & Botanicals | Immune Function | Probiotics & Prebiotics | Proteins, Peptides, Amino Acids
      The Immunity Imperative

      The Immunity Imperative

      The best way to preserve health is through preventive approaches. These nutraceuticals are on the front lines.
      By Alan Richman, Contributing Writer 06.02.17

    • Breaking News | Certifications, Approvals & Patents | Testing

      NSF International Launches Raised Without Antibiotics Certification

      New protocol helps consumers identify animal products that do not contribute to growth of antibiotic-resistant bacteria.
      05.03.17

    • Breaking News | Cardiovascular Health | Minerals | Research | Research News

      Dietary Potassium Linked with Lower Blood Pressure

      Hypertension affects more than 1 billion people worldwide.
      04.17.17


    • Cardiovascular Health | Consumer Trends | Dietary Supplements | Fatty Acids | Functional Foods & Beverages | Healthcare Trends | Healthy Aging | Herbs & Botanicals | Minerals | Omega-3s | Research | Vitamins
      Getting to the Heart of Cardiovascular Health

      Getting to the Heart of Cardiovascular Health

      With so many consumers at risk for heart disease, the need for supporting supplements and natural products is palpable.
      Sean Moloughney, Editor 04.03.17

    • Bone & Joint Health | Cardiovascular Health | Cognitive Function | Consumer Trends | Cosmeceuticals / Nutricosmetics | Diabetes & Blood Sugar Management | Dietary Supplements | Digestive Health | Energy | Eye Health | Functional Foods & Beverages | Healthcare Trends | Healthy Aging | Herbs & Botanicals | Immune Function | Infant & Children's Health | Inflammation | Minerals | Mood Health & Sleep | Natural/Organic | Oral Health | Probiotics & Prebiotics | Sports Nutrition | Vitamins | World Markets
      Getting Ahead of the Curve: Global Nutraceutical Hot Spots

      Getting Ahead of the Curve: Global Nutraceutical Hot Spots

      Sales of consumer health products reached $219 billion worldwide in 2016.
      Dr. A. Elizabeth Sloan & Dr. Catherine Adams Hutt, Sloan Trends, Inc. 03.01.17

      Trending
      • Vitamin D3, Omega-3s, Exercise May Cumulatively Reduce Cancer Risk In Older Adults | Nutraceuticals World
      • Leaven Essential To Launch Branded Botanical Extracts To Global Markets | Nutraceuticals World
      • Vitamin D3, Omega-3s, Exercise May Cumulatively Reduce Cancer Risk in Older Adults
      • Oregon Files Lawsuit Against GNC | Nutraceuticals World
      • Vitamin K2 Status May Impact Blood Pressure And Pulse Wave Velocity | Nutraceuticals World
      Breaking News
      • GOED Creates Infographic Highlighting Omega-3 Health Claims Approved in Europe
      • Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board
      • Expert Consensus Statement: Diet is Best Primary Intervention to Achieve Diabetes Remission
      • Choline Alone May Improve Maternal DHA Status During Pregnancy
      • Cranberry Consumption Linked to Memory and Neurological Function Improvements
      View Breaking News >
      CURRENT ISSUE

      May 2022

      • Aging in Place: Lifestyle Supplements Science-Based Solutions
      • Getting an Edge in Esports: Meeting Health & Nutrition Needs
      • Nutraceuticals for Men: Muscle Health and Performance Nutrition

      Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
      You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

      • About Us
      • Privacy Policy
      • Terms And Conditions
      • Contact Us

      follow us

      Subscribe
      Nutraceuticals World

      Latest Breaking News From Nutraceuticals World

      GOED Creates Infographic Highlighting Omega-3 Health Claims Approved in Europe
      Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board
      Expert Consensus Statement: Diet is Best Primary Intervention to Achieve Diabetes Remission
      Coatings World

      Latest Breaking News From Coatings World

      Teknos Receives EcoVadis Gold Medal for Sustainability Performance
      AkzoNobel and Partners Team Up to Hack Carbon Reduction Challenges
      Five PPG Facilities in Ohio Recognized for Sustainability, Health, Safety Practices
      Medical Product Outsourcing

      Latest Breaking News From Medical Product Outsourcing

      MPO's Most-Read Stories This Week—May 21
      Iterative Scopes Expands its Senior Leadership Team
      Viz.ai Raises $100 Million in Series D Funding
      Contract Pharma

      Latest Breaking News From Contract Pharma

      Piramal Pharma Solutions New API Plant in Canada Now Online
      MG America Appoints Claudio Radossi as President
      Catalent Invests $175M to Expand Mfg. Capabilities at Winchester, KY
      Beauty Packaging

      Latest Breaking News From Beauty Packaging

      Authentic Beauty Concept Launches Second-Generation ‘Refill Bar’
      HASK Beauty Enters Exclusive Partnership with Amazon
      Garance Doré Launches Made in France Skincare Line
      Happi

      Latest Breaking News From Happi

      SPF Setting Spray, Lip Contour and Knotless Braids Are Hot Trends: Spate
      Nutrafol Launches Collagen Infusion
      ÄZ Craft Luxury Haircare Products Support All Hairstyles
      Ink World

      Latest Breaking News From Ink World

      Weekly Recap: Zeller+Gmelin, Sun Chemical and Kornit Top This Week’s News
      Nazdar Celebrates 100 Years with a New Look
      hubergroup Chemicals Exhibits at Paint India for First Time
      Label & Narrow Web

      Latest Breaking News From Label & Narrow Web

      Specialty announces move to new facility
      Mark Andy hosts dealer's open house in Warsaw
      Nazdar celebrates 100th anniversary with refreshed brand identity
      Nonwovens Industry

      Latest Breaking News From Nonwovens Industry

      3M to Expand in Nebraska
      Nicely Offers Nonwoven Slitters, Winders
      'Right' Hygiene Conference to be Held in June
      Orthopedic Design & Technology

      Latest Breaking News From Orthopedic Design & Technology

      ODT's Most Read Stories This Week—May 21
      FDA Clears Anika Therapeutics' X-Twist Knotless Fixation System
      Paragon 28 Rolls Out TenoTac 2.0 Hammertoe and Soft Tissue Repair
      Printed Electronics Now

      Latest Breaking News From Printed Electronics Now

      Weekly Recap: Graphene Flagship, Japan Display and LG Display Top This Week’s Stories
      Evonik Launches New Processing Aids for PV Wafer Cutting
      NREL Creates Highest Efficiency 1-Sun Solar Cell

      Copyright © 2022 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

      AD BLOCKER DETECTED

      Our website is made possible by displaying online advertisements to our visitors.
      Please consider supporting us by disabling your ad blocker.


      FREE SUBSCRIPTION Already a subscriber? Login