• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Health Products Association - China Executive Director Reflects on Market Dynamics, Challenges

    Blood Sugar Management: Personalized Testing Drives Home The Need for Early Intervention

    New and Evolving Formulation Options Must Be Mindful of Blood Sugar Maintenance

    Tapping Functional Beverages to Meet Modern Wellness Needs

    Adaptogens: Where Ancient Remedies Meet Modern Wellness Products
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    CoQ10 and Royal Jelly Supplementation May Improve High Intensity Exercise

    Shiitake Mushroom Extract Appears Helpful in HPV Infections

    Fi & Hi Europe Returns with Over 20,000 Global Attendees Expected

    United Plant Savers Launches First Film Festival

    Azelis Opens Food and Nutrition Lab in Cairo, Egypt
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    CoQ10 and Royal Jelly Supplementation May Improve High Intensity Exercise

    Shiitake Mushroom Extract Appears Helpful in HPV Infections

    United Plant Savers Launches First Film Festival

    Roquette Launches Nutralys Rice Protein

    Upcycled Coffeeberry® Cascara Offers Versatility in Functional Beverage Development
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    CoQ10 and Royal Jelly Supplementation May Improve High Intensity Exercise

    Shiitake Mushroom Extract Appears Helpful in HPV Infections

    Fi & Hi Europe Returns with Over 20,000 Global Attendees Expected

    Azelis Opens Food and Nutrition Lab in Cairo, Egypt

    Florida Food Products Acquires Javo
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    CoQ10 and Royal Jelly Supplementation May Improve High Intensity Exercise

    Shiitake Mushroom Extract Appears Helpful in HPV Infections

    Upcycled Coffeeberry® Cascara Offers Versatility in Functional Beverage Development

    Botanical Gum for Kids Aims to Curb Sugar Cravings

    Combination of Collagen and Boswellia Serrata Shown to Reduce Joint Discomfort
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    KLK OLEO

    Botanic Healthcare LLC

    Aiya America, Inc. (Aiya Matcha)

    Ecuadorian Rainforest

    ESHA Research
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    KLK OLEO

    Botanic Healthcare LLC

    Aiya America, Inc. (Aiya Matcha)

    Ecuadorian Rainforest

    ESHA Research
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Online Exclusives

    Milk Thistle and Lung Cancer

    University of Colorado Cancer Center finds milk thistle extract stops lung cancer in mice.

    Related CONTENT
    • NIH Study Confirms Superior Benefit of AREDS2 Formula for Eye Health
    • Cocoa Flavanol Supplementation Associated with 27% Reduction in Cardiovascular Death
    • In Memoriam: Robin Pask Donkersloot (1948-2021), Nutraceuticals World Publisher, 1997-2004
    • Lycored to Focus on Skin Care from Inside Out
    • Vitamin D Shows Promise in Reducing Cancer in Older Women
    Joanna Cosgrove, Online Editor01.09.12
    Over the course of 2000 years, milk thistle (Silybum marianum) has earned a beneficial reputation in matters relating to the liver, kidneys and gall bladder. Its most well known compound, the flavonoid silymarin derived from the seed of the plant, has both antioxidant and anti-inflammatory properties and has been the subject of many animal and human studies that have yielded mixed results. The most recent study of note focused on silibinin, another component of milk thistle, and its effect on cancer cells in mice.
     
    In a study published in the journal Molecular Carcinogenesis,researchers at the University of Colorado Cancer Center treated lung cancer cells in mice with silibinin and found the compound inhibited tumorigenesis in part by targeting the tumor’s microenvironment.
     
    An article published by the University of Colorado Denver explained the foundation and scope of the study, noting that cells are governed by a chain of signals that accumulate and lead to an end product. To manipulate a cell’s end product, one must discover how to break a link in the signaling chain that leads to it.
     
    In the case of this study, tissue with wound-like conditions allowed tumors to grow and spread. The end products in the cell signal chain resulted in cyclooxygenase 2 (COX2) and inducible nitric oxide synthase (iNOS)enzymes which played a role in the inflammatory response to perceived wounds and, subsequently, in tumor growth. Early in the signaling chain that led to those unwanted enzymes were STAT1 and STAT3—transcription factors that allowed the blueprint of DNA to bind with proteins that continue the signal cascade, eventually leading to the production of harmful COX2 and iNOS. By stopping STAT1 and STAT3, the chains that led to COX2 and iNOS enzymes were broken, halting the growth of lung tumors.
     
    Researchers at the University of Colorado applied the aforementioned theory to mouse lung cancer cells, treating the cells with silibinin, which subsequently removed the “molecular billboards” that signal wound-like conditions, effectively stopping the spread of lung cancers, the researchers reported.
     
    “This relatively nontoxic substance—a derivative of milk thistle, called silibinin—was able to inhibit the upstream signals that lead to the expression of COX2 and iNOS,” commented Alpna Tyagi, PhD, of the University of Colorado Skaggs School of Pharmacy. Dr. Tyagi works in the lab of University of Colorado Cancer Center investigator Rajesh Agarwal, PhD.
     
    In addition, Dr. Tyagi and her colleagues compared the effects of silibinin to drugs currently in clinical trials for lung cancer. Would drugs that target other signaling pathways—other linked chains—similarly cut into the production of COX2 and iNOS?
     
    It turned out that inhibiting the chains of JAK1/2 and MEK in combination, and also inhibiting the signaling pathways of EGFR and NF-kB in combination, blocked the ability of STAT1 and STAT3 to trap the energy they needed to eventually signal COX2 and iNOS production.
     
    Compared to multi-million dollar lung cancer drugs, naturally-occurring silibinin blocked not only the expression of COX2 and iNOS, but also the migration of existing lung cancer cells.
     
    “Together, we showed that STAT3 and STAT1 could be valuable chemopreventive and therapeutic targets within the lung tumor microenvironment in addition to being targets within tumor itself, and that silibinin inhibits their activation as a plausible mechanism of its efficacy against lung cancer,” the researchers concluded.
     
    “What we showed is that STAT1 and STAT3 may be promising therapeutic targets in the treatment of lung cancer, no matter how you target them,” echoed Dr. Tyagi. “And also that naturally-derived products like silibinin may be as effective as today’s best treatments.”
     
    This research endeavor was supported by a grant from the National Cancer Institute.
    Related Searches
    • Energy
    • Enzymes
    • Research
    • Proteins
    Related Knowledge Center
    • Enzymes
    • Research
    Suggested For You
    NIH Study Confirms Superior Benefit of AREDS2 Formula for Eye Health NIH Study Confirms Superior Benefit of AREDS2 Formula for Eye Health
    Cocoa Flavanol Supplementation Associated with 27% Reduction in Cardiovascular Death Cocoa Flavanol Supplementation Associated with 27% Reduction in Cardiovascular Death
    In Memoriam: Robin Pask Donkersloot (1948-2021), Nutraceuticals World Publisher, 1997-2004 In Memoriam: Robin Pask Donkersloot (1948-2021), Nutraceuticals World Publisher, 1997-2004
    Lycored to Focus on Skin Care from Inside Out Lycored to Focus on Skin Care from Inside Out
    Vitamin D Shows Promise in Reducing Cancer in Older Women Vitamin D Shows Promise in Reducing Cancer in Older Women
    Weighty Matters: Implications for Repeal of the Affordable Care Act Weighty Matters: Implications for Repeal of the Affordable Care Act
    In Vivo Study Finds Supplement Enhances Breast Cancer Drug Treatment In Vivo Study Finds Supplement Enhances Breast Cancer Drug Treatment
    Prebiotic Shown to Improve Appetite Control in Obese Children Prebiotic Shown to Improve Appetite Control in Obese Children
    Curcumin May Improve Vascular Endothelial Function in Older Adults Curcumin May Improve Vascular Endothelial Function in Older Adults
    Journalism Fails when Stories are not Adequately Verified Journalism Fails when Stories are not Adequately Verified
    New Article Makes Recommendations to Combat Obesity New Article Makes Recommendations to Combat Obesity
    Vitamin D Levels Linked to Survival Rates Among Cancer Patients Vitamin D Levels Linked to Survival Rates Among Cancer Patients
    Vitamin D Improves Survival Rates Among Cancer Patients Vitamin D Improves Survival Rates Among Cancer Patients
    Kava Root Study Shows Promise for Lung Cancer Prevention Kava Root Study Shows Promise for Lung Cancer Prevention
    Kava Root Study Shows Promise for Lung Cancer Prevention Kava Root Study Shows Promise for Lung Cancer Prevention

    Related Breaking News

    • Antioxidants | Breaking News | Dietary Supplements | Eye Health | Healthy Aging | Medical Nutrition | Research | Research News | Vitamins
      NIH Study Confirms Superior Benefit of AREDS2 Formula for Eye Health

      NIH Study Confirms Superior Benefit of AREDS2 Formula for Eye Health

      Ten years after its introduction, additional research confirms the second AREDS formula had increased efficacy in age-related macular degeneration.
      06.02.22

    • Antioxidants | Cancer Risk | Cardiovascular Health | Herbs & Botanicals | Minerals | Research | Research News | Vitamins
      Cocoa Flavanol Supplementation Associated with 27% Reduction in Cardiovascular Death

      Cocoa Flavanol Supplementation Associated with 27% Reduction in Cardiovascular Death

      Trial finds modest reduction in cardiovascular events for those taking cocoa extract, no association between multivitamins and reduced risk of cancer or CVD.
      By Sean Moloughney, Editor 03.16.22

    • Dietary Supplements | Herbs & Botanicals | Omega-3s | World Markets
      In Memoriam: Robin Pask Donkersloot (1948-2021), Nutraceuticals World Publisher, 1997-2004

      In Memoriam: Robin Pask Donkersloot (1948-2021), Nutraceuticals World Publisher, 1997-2004

      The Founding Publisher of NW passed away at her home in Vermont on Nov. 9 following a brief battle with lung cancer.
      By Ellen Schutt, Founding Editor, Nutraceuticals World 12.04.21


    • Lycored to Focus on Skin Care from Inside Out

      Lycoderm is a unique blend of carotenoids that fosters skin wellness from within.
      05.08.17

    • Cancer Risk | Minerals | Research | Vitamins | Women's Health
      Vitamin D Shows Promise in Reducing Cancer in Older Women

      Vitamin D Shows Promise in Reducing Cancer in Older Women

      Higher blood levels of 25(OH)D were associated with lower cancer risk, according to an RCT published in JAMA.
      Sean Moloughney, Editor 04.04.17

    Loading, Please Wait..
    Trending
    • Three Grams Of Omega-3s May Be Optimal Dose For Reducing Blood Pressure
    • 3 grams of Omega-3s May be Optimal Dose for Reducing Blood Pressu
    • Olive/Pomegranate Extract May Improve Dyslipidemia
    • First Day Life Shuts Down Children's Behavioral, Cognitive Health Claims Following Challenge
    Breaking News
    • CoQ10 and Royal Jelly Supplementation May Improve High Intensity Exercise
    • Shiitake Mushroom Extract Appears Helpful in HPV Infections
    • Fi & Hi Europe Returns with Over 20,000 Global Attendees Expected
    • United Plant Savers Launches First Film Festival
    • Azelis Opens Food and Nutrition Lab in Cairo, Egypt
    View Breaking News >
    CURRENT ISSUE

    June 2022

    • Tapping Functional Beverages to Meet Modern Wellness Needs
    • Adaptogens: Where Ancient Remedies Meet Modern Wellness Products
    • New and Evolving Formulation Options Must Be Mindful of Blood Sugar Maintenance
    • Health Products Association - China Executive Director Reflects on Market Dynamics, Challenges
    • Blood Sugar Management: Personalized Testing Drives Home The Need for Early Intervention
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    CoQ10 and Royal Jelly Supplementation May Improve High Intensity Exercise
    Shiitake Mushroom Extract Appears Helpful in HPV Infections
    Fi & Hi Europe Returns with Over 20,000 Global Attendees Expected
    Coatings World

    Latest Breaking News From Coatings World

    Barentz Showcases Lincoln MFG’s New ISO 9001:2015 Certification
    H.M. Royal Becomes Exclusive OCSiAl Distributor
    American Colors to Expand Sandusky, Ohio Facility
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    Cepheid, BioGX Partner to Create GeneXpert Monkeypox Test
    Siemens' Varian Gains FDA IDE Nod for FAST-02 Trial
    Acutus Medical Launches AcQCross Line Extension
    Contract Pharma

    Latest Breaking News From Contract Pharma

    Ixaka & Minaris Sign Tech Transfer & GMP Manufacturing Agreement for Cell Therapy Candidate
    Pfizer, BioNTech Adapt COVID Vax Against Omicron
    CoreRx Expands Capabilities
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Top 5 Beauty Tech Trends at Perfect Corp.'s Global Forum
    John Frieda Supports the LGBTQIA+ Community
    Athena Club Launches in Canada
    Happi

    Latest Breaking News From Happi

    Fencing Champion Bebe Vio Grandis Named Spokeswoman of L’Oréal Paris
    Past Henkel Exec Christian Chopra Named President of Scotch Porter
    Color Street Celebrates Foster, Adoption Awareness with Limited-Edition Print
    Ink World

    Latest Breaking News From Ink World

    Barentz Highlights Lincoln MFG’s New ISO 9001:2015 Certification
    Ingevity Appoints Christine Stunyo as Chief Human Resources Officer
    Dr. Tammo Boinowitz to Join Management Board of ALTANA AG
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    Harveer Sahni recognized with Global Achievement Award
    Color-Logic partners with Taktiful 
    ALTANA announces Management Board change
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Fibertex Personal Care Awarded EcoVadis Awards for Sustainability
    Yanpai Orders Batt Forming Equipment for Needlepunch Line
    Weekly Recap: SWM and Neenah Introduce Mativ Inc., Avgol honored for Biotransformation Technology & More
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    Researchers Discover Novel Patching Material for Bone Defects
    Boston Centerless Opens Second Manufacturing Plant in Indiana
    Researchers Develop Patient-Specific 3D-Printed Smart Metamaterial Implants
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Identiv-Powered CVS Spoken Rx Wins NFC Forum 2022 Innovation Award
    LG Display Announces Winners of This Year’s OLEDs GO! Competition
    Weekly Recap: eMagin, Applied Materials, and Schott Top This Week’s Stories

    Copyright © 2022 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login