• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Contract Manufacturing: Trials & Tribulations of Today’s Supply Chains

    Analytical Testing in Nutraceuticals: Methods and Mindsets to Uphold Quality

    Nutrition and Flavor: Formulating for Modern Product Preferences

    What Do Consumers Know About the Gut Microbiome?

    How Will the European Green Deal Impact Dietary Supplements?
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process

    ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market

    Tazo Transitions to Regenerative Organic Agriculture

    Protein Ingredient Formulated for Chronic Kidney Disease Patients

    IADSA Calls for Addressing Discrepancies in Vitamin C Recommendations
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process

    ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market

    Tazo Transitions to Regenerative Organic Agriculture

    Protein Ingredient Formulated for Chronic Kidney Disease Patients

    IADSA Calls for Addressing Discrepancies in Vitamin C Recommendations
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process

    ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market

    Tazo Transitions to Regenerative Organic Agriculture

    Protein Ingredient Formulated for Chronic Kidney Disease Patients

    IADSA Calls for Addressing Discrepancies in Vitamin C Recommendations
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process

    Caffeine-Free Energy Supplement Linked to Alertness, Fatigue Benefits

    Monk Fruit Sweetener May Have Prebiotic Activity, Study Finds

    People with Low-Fiber Diets Benefit the Most from Fiber Supplements, Study Finds

    Gut Microbiome May Be Part of Link Between Red Meat and Heart Disease Risk
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    Gencor

    BGG World

    Ecuadorian Rainforest

    Sabinsa Corporation

    JRS Pharma
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    Gencor

    BGG World

    Ecuadorian Rainforest

    Sabinsa Corporation

    JRS Pharma
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Online Exclusives

    Antioxidants and Melanoma Risk

    New Kaiser Permanente study refutes the 2007 SUVIMAX connection.

    Related CONTENT
    • Kellogg Venture Capital Fund Invests in Moringa Manufacturer
    • SuperNutrition Debuts SimplyOne CalNatal
    • SuperNutrition Reformulates with MenaQ7 Vitamin K2
    • MenaQ7 Included in PreNatal Blend
    • Numi Launches Turmeric Tea Line
    Joanna Cosgrove11.19.09
    Melanoma, the uncontrolled growth of pigment-producing cells, is the most serious form of skin cancer and is expected to afflict an estimated 122,000 men and women in the U.S. in 2009, according to the American Academy of Dermatology. Two years ago, the Supplementation in Vitamins and Mineral Antioxidants (SUVIMAX) study (Journal of Nutrition 137:2098-2105, Sept. 2007) reported a 4-fold higher melanoma risk in women randomized to receive a supplement with nutritionally appropriate doses of antioxidants. However, a new study from researchers at Kaiser Permanente in Oakland, CA, took the SUVIMAX study to task, refuting its results and reassuring consumers that taking vitamins will not increase their chances of developing melanoma.

    The 2007 SUVIMAX study tested the efficacy of antioxidants in reducing the cancer incidence in the general population and found that oral daily supplementation with a combination of antioxidants—120 mg of vitamin C, 30 mg of vitamin E, 6 mg of beta carotene, 100 μg of selenium and 20 mg of zinc—over the course of 7.5 years increased the incidence of melanoma in women by 4%. The study results prompted the researchers to conclude that their results suggested that “regular intake of such nutrients may be associated with harmful effects.”

    Kaiser Permanente researchers sought to confirm these findings by examining melanoma incidence in their Vitamins and Lifestyle (VITAL) study, a 2-year-long population-based prospective cohort study that examined a total of 69,671 men and women from western Washington state, aged 50-76. The participants answered a lengthy questionnaire about their lifestyle, health history, diet, supplement use, personal characteristics and cancer risk factors in spanning the past decade. About 66% of the participants were either current or past users of multivitamins.

    Researchers paid particular attention to the self-reported use of the five supplements used in the SUVIMAX trial—vitamin C, vitamin E, beta carotene, selenium and zinc—in the 10 years before baseline. The doses of vitamin C, vitamin E and zinc supplements used in the SUVIMAX study corresponded to the amounts found in a standard multivitamin. In the SUVIMAX study, the beta carotene and selenium doses were several times greater than those in a standard multivitamin, prompting researchers to conduct further analyses on the supplemental use of those two nutrients.

    In the end, the researchers did not detect a significant connection between multivitamin use and melanoma risk in women or in men. They also did not observe increased melanoma risk with the use of supplemental beta carotene at doses comparable with those of the SUVIMAX study. Their complete findings were published in the Archives of Dermatology (Vol. 145 (No. 8), Aug. 2009).

    Points of Conjecture



    In addition to their vitamin research, the Kaiser Permanente team also speculated on where the SUVIMAX study went wrong, writing that its results could be attributed to “methodological shortcomings.”

    “Their analysis,” they wrote, “was limited to a subsample of participants who agreed to answer a single question on their lifetime sun exposure ('How would you describe the intensity of your skin’s exposure to the sun during your lifetime?'), which could introduce selection bias and limit generalizability. Also, the response to that question, which was the only melanoma risk factor ascertained other than age, current smoking status and latitude of residence, was excluded from their multivariable analysis.”

    The study also identified few incident melanomas, they said, possibly “owing to inaccurate case ascertainment, which may explain the 5-fold lower rates of incident melanomas in the SUVIMAX trial (25 cases per 100,000 person-years) compared with the VITAL study (120 cases per 100,000 person-years).”

    They also cited several limitations in the SUVIMAX study, including the absence of detailed information on some known melanoma risk factors, such as sunlight exposure at early ages and number of birthmarks, moles or any other kind of skin growths (nevi) the participant might have had.

    With regard to antioxidant supplement usage, Kaiser Permanente researchers also pointed to SUVIMAX’s lack of physiologic measures (such as serum levels) of such usage, relying instead on self-reported use data. “In summary,” they wrote, “these data suggest no association between self-reported multivitamin use and supplemental selenium and beta carotene use similar to doses used in the SUVIMAX study and melanoma risk.”

    They concluded by advising that the results of the SUVIMAX study “should be interpreted with caution.”

    Lead study author, Maryam Asgari, MD, MPH, dermatologist and research scientist, Kaiser Permanente, said she was inspired to convene this study because she was worried the results of the SUVIMAX trail were misleading. “I was concerned about the results of the SUVIMAX trial suggesting that women who were taking nutritionally appropriate doses of certain supplements were at increased risk of melanoma,” she said, noting that at present she is not planning additional research in this area of study.

    “Because an estimated 48% to 55% of U.S. adults use vitamin or mineral supplements regularly, it’s important for consumers to know that our study did not replicate the findings from the SUVIMAX study,” concluded Dr. Asgari. “No one study can tell the whole story, so it’s important for scientists and consumers alike to consider the entire evidence base.”
    Related Searches
    • Antioxidants
    • Dietary Supplements
    • Cancer Risk
    • Research
    Related Knowledge Center
    • Research
    • Vitamins
    • Dietary Supplements
    Suggested For You
    Kellogg Venture Capital Fund Invests in Moringa Manufacturer Kellogg Venture Capital Fund Invests in Moringa Manufacturer
    SuperNutrition Debuts SimplyOne CalNatal SuperNutrition Debuts SimplyOne CalNatal
    SuperNutrition Reformulates with MenaQ7 Vitamin K2 SuperNutrition Reformulates with MenaQ7 Vitamin K2
    MenaQ7 Included in PreNatal Blend MenaQ7 Included in PreNatal Blend
    Numi Launches Turmeric Tea Line Numi Launches Turmeric Tea Line
    NIH Adds Substantial Set of Genetic, Health Information to Online Database NIH Adds Substantial Set of Genetic, Health Information to Online Database
    MarketWatch MarketWatch
    Antioxidant Science Drives New Skin Care Developments
Antioxidant Science Drives New Skin Care Developments
    Obesity Costs U.S. $147 Billion a Year Obesity Costs U.S. $147 Billion a Year
    Spotlights Shine on Vitamin D Spotlights Shine on Vitamin D
    Public Health Organization Stresses Importance of Vitamin D Intake Public Health Organization Stresses Importance of Vitamin D Intake
    Alternative therapies Alternative therapies
     Alternative therapies Alternative therapies
    Phoenix Biologics to Manufacture Migraine Prevention Product Phoenix Biologics to Manufacture Migraine Prevention Product
    Heart Thrive Cakes Heart Thrive Cakes

    Related Breaking News

    • Breaking News | Herbs & Botanicals | Industry & Market News
      Kellogg Venture Capital Fund Invests in Moringa Manufacturer

      Kellogg Venture Capital Fund Invests in Moringa Manufacturer

      eighteen94 makes first investment in U.S.-based superfood company Kuli Kuli.
      01.17.17

    • Dietary Supplements | Infant & Children's Health | Minerals | Products | Sexual & Reproductive Health | Vitamins | Women's Health
      SuperNutrition Debuts SimplyOne CalNatal

      SuperNutrition Debuts SimplyOne CalNatal

      Supplement designed to help moms build and maintain stronger bones.
      03.08.16

    • Bone & Joint Health | Cardiovascular Health | Dietary Supplements | Products | Vitamins

      SuperNutrition Reformulates with MenaQ7 Vitamin K2

      The decision comes on the heels of the growing scientific research demonstrating the benefits of vitamin K2 (MK-7).
      01.12.16


    • Dietary Supplements | Infant & Children's Health | Products | Sexual & Reproductive Health | Women's Health

      MenaQ7 Included in PreNatal Blend

      ...
      09.30.15

    • Functional Foods & Beverages | Products
      Numi Launches Turmeric Tea Line

      Numi Launches Turmeric Tea Line

      ...
      05.11.15

    Loading, Please Wait..
    Trending
    • First Day Life Shuts Down Children's Behavioral, Cognitive Health Claims Following Challenge
    • Study Examines Vitamin K2 Content In Cheese
    • Chenland Nutritionals Self-Affirms GRAS For Cumin UP60 Ingredient
    • Pycnogenol Evidenced To Have Skin Benefits In Dermatology Study
    • ADM And Benson Hill Partner To Scale High Protein Soy For U.S. Market
    Breaking News
    • Charlotte’s Web Sports Product Line to Undergo NSF Certification Process
    • ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market
    • Tazo Transitions to Regenerative Organic Agriculture
    • Protein Ingredient Formulated for Chronic Kidney Disease Patients
    • IADSA Calls for Addressing Discrepancies in Vitamin C Recommendations
    View Breaking News >
    CURRENT ISSUE

    July/August 2022

    • A Growing Herbal Products Market Still Faces Formidable Threats, Challenges
    • Analytical Testing in Nutraceuticals: Methods and Mindsets to Uphold Quality
    • Nutrition and Flavor: Formulating for Modern Product Preferences
    • Contract Manufacturing: Trials & Tribulations of Today’s Supply Chains
    • How Will the European Green Deal Impact Dietary Supplements?
    • What Do Consumers Know About the Gut Microbiome?
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process
    ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market
    Tazo Transitions to Regenerative Organic Agriculture
    Coatings World

    Latest Breaking News From Coatings World

    Valspar Reveals Fresh Lineup of New Shades in 2023 Colors of the Year
    Evonik Grows Strongly in 1H 2022
    PPG Chairman and CEO Joins Disability:IN Effort to Advance Disability Inclusion
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    BD Recalls Intraosseous Products Over Multiple Issues
    Rapid Medical Expands U.S. Portfolio
    MMS Holdings Partners With Lindsay Goldberg
    Contract Pharma

    Latest Breaking News From Contract Pharma

    Almac Invests $65M to Expand North American HQ
    Pace Appoints Nisheet Gupta as EVP and Chief Financial Officer
    West Pharmaceutical Makes Strategic Investment in Latch Medical
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Arkay Chairman Emeritus Howard Kaneff Has Died
    Nutricosmetics Market to Hit $13.7 Billion by 2030
    Estée Lauder Pledges 100% Electric Fleet of Vehicles by 2030
    Happi

    Latest Breaking News From Happi

    Murad Unveils Supplement Product Lineup to Combat Acne, Aging
    R+Co Launches New Hairstyling Products
    Clinique Launches Pop Plush Creamy Gloss in its Iconic Black Honey Hue
    Ink World

    Latest Breaking News From Ink World

    Evonik Enjoys 31% Growth in 1H 2022
    Sun Chemical Returns to Labelexpo Americas 2022
    DIC Reports Consolidated Financial Results 1H 2022
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    Hybrid Software joins The Flexo Xperience Center
    Flexo Wash LLC and Mike Potter celebrate 20 years
    Colordyne hosts open house featuring hybrid print technology
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Focke & Co. to Host Destination: Your Hygiene Hub on August 31
    Exports Dominate Chinese Trade of Tissues, Hygiene Products and Wipes
    Freudenberg to Present Friction Inserts for Wind Energy
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    Study Results Released for Abbott's Concussion Blood Test
    Bone Growth Stimulators Market to Top $3B by 2030
    Surgalign, RTI Settle Lawsuit Over OEM Biz Sale
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Zebra Technologies’ Emission Reduction Targets Validated by SBTi
    Identiv Delivers Impressive 41% Year-over-Year Growth in RFID Business
    Stratasys Signs Agreement to Acquire Covestro’s Additive Manufacturing Materials Business

    Copyright © 2022 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login