• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Nutraceuticals for Men: Muscle Health and Performance Nutrition

    Aging in Place: Healthy Lifestyles Supplement Science-Based Solutions

    Getting an Edge in Esports: Meeting the Health Needs of Competitive Gamers

    Beyond CBD: Cannabis Compounds Warrant Recognition and More Research

    Leveling Out the Energy Segment for Mainstream, and Rethinking Caffeine
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board

    Expert Consensus Statement: Diet is Best Primary Intervention to Achieve Diabetes Remission

    Choline Alone May Improve Maternal DHA Status During Pregnancy

    Cranberry Consumption Linked to Memory and Neurological Function Improvements

    Bilberon Bilberry Extract Receives U.S. Patent For Eye Strain, Neck/Shoulder Pain
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board

    Choline Alone May Improve Maternal DHA Status During Pregnancy

    Cranberry Consumption Linked to Memory and Neurological Function Improvements

    Bilberon Bilberry Extract Receives U.S. Patent For Eye Strain, Neck/Shoulder Pain

    Jordan Process Receives Nutrasource ICAP Certification for CBD
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board

    Expert Consensus Statement: Diet is Best Primary Intervention to Achieve Diabetes Remission

    Choline Alone May Improve Maternal DHA Status During Pregnancy

    Cranberry Consumption Linked to Memory and Neurological Function Improvements

    Bilberon Bilberry Extract Receives U.S. Patent For Eye Strain, Neck/Shoulder Pain
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board

    Expert Consensus Statement: Diet is Best Primary Intervention to Achieve Diabetes Remission

    Choline Alone May Improve Maternal DHA Status During Pregnancy

    Cranberry Consumption Linked to Memory and Neurological Function Improvements

    Bilberon Bilberry Extract Receives U.S. Patent For Eye Strain, Neck/Shoulder Pain
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    ESHA Research

    Xsto Solutions

    Sabinsa Corporation

    Atlantia Clinical Trials

    Aiya America, Inc. (Aiya Matcha)
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    ESHA Research

    Xsto Solutions

    Sabinsa Corporation

    Atlantia Clinical Trials

    Aiya America, Inc. (Aiya Matcha)
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Features

    Managing AGE(s): The Other Health Marker

    With consumer focus on disease prevention and anti-aging growing, a new marker of health may be emerging.

    Related CONTENT
    • Mibelle Biochemistry Launches FenuKale Nu Ingredient
    • Lanfam LLC Launches Medical Food for Pain Relief
    • Top Health Benefits of Glutathione, the Master Antioxidant
    • Quercetin in the Antioxidant Spotlight
    • Mitsubishi Receives U.S. Patent for Glutathione Ingredient
    Sean Moloughney, Editor09.02.13
    Poor eating habits, stress, lack of sleep, sun exposure and other lifestyle factors can accelerate the natural aging process.

    Harmful compounds that attack organs and healthy tissue, known as advanced glycation end-products (AGEs), result from chemical processes in the human body that are brought on by poor lifestyle habits. AGEs form when a sugar molecule and a protein peptide bind together. They can develop from consumption of sugary, processed foods or foods that have been browned. While the body needs sugars and proteins to fuel normal functions, excess sugar in the blood results in higher than normal AGE levels.

    AGEs are emerging as medical markers for the aging of internal organs, tissues and body systems, according to the AGE Foundation, a non-profit organization focused on generating awareness. Linked to many age-related health concerns, AGEs can be measured by a reader that scans levels using an LED light.

    “Science now shows that AGEs accumulate when foods are cooked at very high temperature and the whole browning process really accelerates AGEs,” noted Pat Baird, RD, nutrition/health consultant and author. “Cooking methods like steaming, poaching, boiling and slow cookers are a good way to reduce AGEs. Slow cookers are very popular right now. This is the ideal time to change some of the methods of cooking.”

    Lifestyle modifications for preventing AGE accumulation and reducing inflammation include regular exercise. “Specifically, exercise burns excess sugar in the blood before it can become harmful,” Ms. Baird added. “We know that people who are highly stressed have higher levels of inflammation. It’s the same thing with sleep; people who are sleep deprived (i.e., getting less than 7 hours of sleep per night) tend to be overweight, are more likely to have heart disease and have higher levels of inflammation.”

    The Iridoid Solution
    Research indicates a specific class of phytochemicals known as iridoids, which fall under the larger subcategory of terpenoids, can help defend against AGEs. The two major types of iridoids include deacetylasperulosidic acid (DAA) and asperulosidic acid (AA).

    According to Brett West, director of research at Utah-based Morinda Inc., human clinical trials involving heavy smokers have confirmed that iridoids discovered in noni fruit offer protective effects against DNA damage in white blood cells. Morinda’s Tahitian Noni Juice was compared with placebo in the clinical trials.

    Morinda citrifolia, commonly known as noni, is a tropical tree that grows on the islands of the South Pacific, Southeast Asia, Central America, the Indian subcontinent and in the Caribbean. The fruit and leaves have a history of use both as food and for the promotion of health. With a well-established safety profile, noni has received Novel Food approval in Europe.

    “In looking for other sources of iridoids, we found they’re not very common to fruits,” noted Mr. West, adding that Cornelian cherries found in Asia (Cornus officinalis) and Europe (Cornus mas) also contain iridoids. “We reviewed some research done in Japan on diabetic rats where iridoids from the Cornelian cherries lowered blood sugar levels and also lowered AGE levels in the kidneys of these animals.”

    Cranberries, blueberries (Vaccinium) and olive leaf (Olea europaea) offer additional sources of iridoids, though in smaller concentrations than noni. Formulated to feature these iridoid sources, TruAge Max, developed by Morinda, is a dietary supplement shown to lower AGE levels. In a recent study, diabetic participants who consumed 60 mL per day lowered AGEs by up to 24%, according to the company.

    Researchers have uncovered multiple ways in which TruAge Max helps control AGEs, including preventing the formation of AGEs by helping to metabolize protein and fat before they can bind and become AGEs, stabilizing blood sugar levels and reducing levels of free radicals in the body. A clinical study among adults found the iridoids in TruAge Max reduced free radicals in participants by 19%.

    AGEs & Free Radicals
    While AGEs and free radicals have “similar personality attributes,” according to Mr. West, they are distinct. “They are both reactive,” he noted. “They like to react with other things, and they do that very rapidly. A free radical is an issue of an unpaired electron that’s looking for a partner. One of the properties of AGEs involves dicarbonyls—these bonds that are highly reactive. So the mechanism of action is different.”

    The formation of free radicals is much more rapid than AGEs that develop from elevated sugars, he added.

    “If you started at the beginning of the reaction with protein and sugar binding, then it goes through a series of chemical reactions, over weeks to months time, to actually form the advanced glycation end-product at the very end. In the middle is something called an amadori product. An example is Hemoglobin A1C or glycosylated hemoglobin, that people get measured to see if they have diabetes. The snapshot you get from that is 3 months previous, showing how well you’ve controlled sugar.”

    A “vicious cycle” between oxidative stress and AGEs can develop. “Things that cause oxidative stress in the body actually speed up reaction rates that form AGEs,” Mr. West continued. “So one contributes to the other. There is some back and forth. Oxidative stress can increase AGE levels faster and then those elevated levels also interact with receptors on the cells called RAGE (receptor for AGE) that causes a cell response that increases oxidative stress.”

    Essentially, free radicals destroy cells, noted Ms. Baird. “The good news is that many foods, especially fruits and vegetables, contain naturally occurring compounds—plant nutrients that act as antioxidants, which destroy free radicals. We know that free radicals contribute to inflammation, and inflammation contributes to aging. It also contributes to a number of different diseases, like heart disease, diabetes, liver disease and cancer.”

    Ms. Baird stressed the importance of eating a variety of colorful fruits and vegetables. “A lot of these phytochemicals are found in the pigment, and that’s what makes red and yellow and green so important.”

    “I truly believe that beauty starts from the inside out,” she added. Still, the AGE Foundation recently conducted a survey that showed 52% of respondents pay attention to their external physical appearance rather than the internal health of their organs (48%).

    Simple lifestyle changes like drinking more fluids, consuming more fiber (soluble and insoluble) and eating more fruits and vegetables can make a significant difference.

    Moving Science Forward
    While the body naturally rids itself of AGEs, this ability decreases with age. “During the AGE forming process there is a possibility of keeping that somewhat in check, but that declines as we get older,” said Mr. West. “That accumulation can go up if you’re a smoker and if you’re diabetic.”

    Focused on future research, Mr. West recently presented preliminary data from a human clinical trial on skin autofluorescence, a non-invasive AGE marker. He said the intention is to add more people to that trial, and to conduct additional clinicals.

    Mr. West and his colleagues are also interested in further analyzing the mechanism of action for iridoids. “What is it about iridoids that actually slows down or prevents AGE formation?” Currently, iridoids may act as dicarbonyl scavengers, preventing AGE formation; other enzymatic processes may also be at play.
    Related Searches
    • Peptide
    • Anti-Aging
    • Diabetes
    • Fruits
    Related Knowledge Center
    • Antioxidants
    • Functional Foods & Beverages
    • Inflammation
    Suggested For You
    Mibelle Biochemistry Launches FenuKale Nu Ingredient Mibelle Biochemistry Launches FenuKale Nu Ingredient
    Lanfam LLC Launches Medical Food for Pain Relief Lanfam LLC Launches Medical Food for Pain Relief
    Quercetin in the Antioxidant Spotlight Quercetin in the Antioxidant Spotlight
    Top Health Benefits of Glutathione, the Master Antioxidant Top Health Benefits of Glutathione, the Master Antioxidant
    Mitsubishi Receives U.S. Patent for Glutathione Ingredient Mitsubishi Receives U.S. Patent for Glutathione Ingredient
    Astaxanthin Complex May Help Reduce Self-Reported Pain After Exercise Astaxanthin Complex May Help Reduce Self-Reported Pain After Exercise
    SRW Laboratories Debuts Line of Supplements Targeting Cellular Health SRW Laboratories Debuts Line of Supplements Targeting Cellular Health
    Astaxanthin: Decades of Research and a Wide Net of Benefits Astaxanthin: Decades of Research and a Wide Net of Benefits
    Carlson’s New Kid’s Immune Boost Gummies Feature Astaxanthin and Vitamin C Carlson’s New Kid’s Immune Boost Gummies Feature Astaxanthin and Vitamin C
    Plant-Based Diet May Lead to Lower Ubiquinol Concentrations Plant-Based Diet May Lead to Lower Ubiquinol Concentrations
    Nutricosmetics Reflect Wellness Inside-Out Nutricosmetics Reflect Wellness Inside-Out
     Lycored’s Lumenato Evidenced to Support Collagen Network in the Skin Lycored’s Lumenato Evidenced to Support Collagen Network in the Skin
    Functional Food, Beverage Possibilities Open with GRAS Status of Blue California’s Dihydroquercetin Functional Food, Beverage Possibilities Open with GRAS Status of Blue California’s Dihydroquercetin
    Pilot Study Suggests Tomato Powder has Superior Exercise Recovery Benefits to Lycopene Pilot Study Suggests Tomato Powder has Superior Exercise Recovery Benefits to Lycopene
    Pycnogenol Study Finds Benefits in Fibromyalgia Patients Pycnogenol Study Finds Benefits in Fibromyalgia Patients

    Related Content

    • Breaking News | Cosmeceuticals / Nutricosmetics | Dietary Supplements | Herbs & Botanicals | Skin Health | Supplier News
      Mibelle Biochemistry Launches FenuKale Nu Ingredient

      Mibelle Biochemistry Launches FenuKale Nu Ingredient

      The formula of fenugreek and kale extracts had a protective effect on skin in a human clinical study.
      04.11.22

    • Breaking News | Herbs & Botanicals | Inflammation | Medical Nutrition | Products | Proteins, Peptides, Amino Acids
      Lanfam LLC Launches Medical Food for Pain Relief

      Lanfam LLC Launches Medical Food for Pain Relief

      Proleeva is formulated to address amino acid deficiencies seen in inflammatory disorders and chronic pain.
      03.21.22

    • Antioxidants | Healthy Aging | Immune Function | Inflammation | Proteins, Peptides, Amino Acids
      Top Health Benefits of Glutathione, the Master Antioxidant

      Top Health Benefits of Glutathione, the Master Antioxidant

      GSH stops free radicals from damaging cells while also assisting other antioxidants along the way.
      By Nayan Patel, PharmD, Author of The Glutathione Revolution 03.02.22


    • Antioxidants | Immune Function | Inflammation
      Quercetin in the Antioxidant Spotlight

      Quercetin in the Antioxidant Spotlight

      This flavonol has been used for allergies, heart health, prostate issues, and more.
      By Sean Moloughney, Editor 03.02.22

    • Antioxidants | Breaking News | Certifications, Approvals & Patents | Dietary Supplements | Medical Nutrition | Supplier News | World Markets
      Mitsubishi Receives U.S. Patent for Glutathione Ingredient

      Mitsubishi Receives U.S. Patent for Glutathione Ingredient

      The L-glutathione reduced ingredient Opitac was granted a patent based on applications in non-alcoholic fatty liver disease.
      02.24.22

      Trending
      • Vitamin D3, Omega-3s, Exercise May Cumulatively Reduce Cancer Risk In Older Adults | Nutraceuticals World
      • Leaven Essential To Launch Branded Botanical Extracts To Global Markets | Nutraceuticals World
      • Indena’s Meriva Curcumin Supplement May Benefit Kidney Function
      • Vitamin D3, Omega-3s, Exercise May Cumulatively Reduce Cancer Risk in Older Adults
      • Test On Hydrolyzed Collagen Shows Resoundingly High Bioavailability | Nutraceuticals World
      Breaking News
      • Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board
      • Expert Consensus Statement: Diet is Best Primary Intervention to Achieve Diabetes Remission
      • Choline Alone May Improve Maternal DHA Status During Pregnancy
      • Cranberry Consumption Linked to Memory and Neurological Function Improvements
      • Bilberon Bilberry Extract Receives U.S. Patent For Eye Strain, Neck/Shoulder Pain
      View Breaking News >
      CURRENT ISSUE

      May 2022

      • Aging in Place: Lifestyle Supplements Science-Based Solutions
      • Getting an Edge in Esports: Meeting Health & Nutrition Needs
      • Nutraceuticals for Men: Muscle Health and Performance Nutrition

      Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
      You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

      • About Us
      • Privacy Policy
      • Terms And Conditions
      • Contact Us

      follow us

      Subscribe
      Nutraceuticals World

      Latest Breaking News From Nutraceuticals World

      Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board
      Expert Consensus Statement: Diet is Best Primary Intervention to Achieve Diabetes Remission
      Choline Alone May Improve Maternal DHA Status During Pregnancy
      Coatings World

      Latest Breaking News From Coatings World

      Teknos Receives EcoVadis Gold Medal for Sustainability Performance
      AkzoNobel and Partners Team Up to Hack Carbon Reduction Challenges
      Five PPG Facilities in Ohio Recognized for Sustainability, Health, Safety Practices
      Medical Product Outsourcing

      Latest Breaking News From Medical Product Outsourcing

      Viz.ai Raises $100 Million in Series D Funding
      FDA Clears Arterys' AI Mapping and Quantification Tools
      Prometheus Group Sued Over Reused Catheters and Rectal Sensors
      Contract Pharma

      Latest Breaking News From Contract Pharma

      Catalent Invests $175M to Expand Mfg. Capabilities at Winchester, KY
      Sartorius Expands Manufacturing Site in Tunisia
      BioMoti Partners with Pharma Company to Develop Ovarian Cancer Treatment
      Beauty Packaging

      Latest Breaking News From Beauty Packaging

      HASK Beauty Enters Exclusive Partnership with Amazon
      Garance Doré Launches Made in France Skincare Line
      The World’s Most Popular Perfumes & Celebrity Fragrances
      Happi

      Latest Breaking News From Happi

      Indie Beauty Brand i-On Skincare Releases New Skin Emulsion, AI Diagnostic Tool
      Estée Lauder Companies' New Research on Oxidative Damage, Skin Barrier Function & Hyperpigmentation
      Lush Gay is OK Soap Supports Equality Florida
      Ink World

      Latest Breaking News From Ink World

      hubergroup Chemicals Exhibits at Paint India for First Time
      Award for Sustainability: Evonik Receives Platinum Rating Again
      Nazdar Ink Technologies to Showcase Latest Ink Innovations at FESPA Global Print Expo 2022
      Label & Narrow Web

      Latest Breaking News From Label & Narrow Web

      Dantex Group receives accreditation for Pico digital presses
      Heidelberg USA launches new Print Media Performance & Training Center
      Avery Dennison announces Global Supplier Award winners
      Nonwovens Industry

      Latest Breaking News From Nonwovens Industry

      'Right' Hygiene Conference to be Held in June
      Freudenberg to Present Battery Pack and Liquid Absorbers at Battery Show
      H&V Appoints Vice President and General Counsel
      Orthopedic Design & Technology

      Latest Breaking News From Orthopedic Design & Technology

      FDA Clears Anika Therapeutics' X-Twist Knotless Fixation System
      Paragon 28 Rolls Out TenoTac 2.0 Hammertoe and Soft Tissue Repair
      Cionic Expands Scientific Advisory Board
      Printed Electronics Now

      Latest Breaking News From Printed Electronics Now

      Evonik Launches New Processing Aids for PV Wafer Cutting
      NREL Creates Highest Efficiency 1-Sun Solar Cell
      eMagin Wins People’s Choice Award at Display Week 2022

      Copyright © 2022 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

      AD BLOCKER DETECTED

      Our website is made possible by displaying online advertisements to our visitors.
      Please consider supporting us by disabling your ad blocker.


      FREE SUBSCRIPTION Already a subscriber? Login