• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Health Products Association - China Executive Director Reflects on Market Dynamics, Challenges

    Blood Sugar Management: Personalized Testing Drives Home The Need for Early Intervention

    New and Evolving Formulation Options Must Be Mindful of Blood Sugar Maintenance

    Tapping Functional Beverages to Meet Modern Wellness Needs

    Adaptogens: Where Ancient Remedies Meet Modern Wellness Products
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    CoQ10 and Royal Jelly Supplementation May Improve High Intensity Exercise

    Shiitake Mushroom Extract Appears Helpful in HPV Infections

    Fi & Hi Europe Returns with Over 20,000 Global Attendees Expected

    United Plant Savers Launches First Film Festival

    Azelis Opens Food and Nutrition Lab in Cairo, Egypt
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    CoQ10 and Royal Jelly Supplementation May Improve High Intensity Exercise

    Shiitake Mushroom Extract Appears Helpful in HPV Infections

    United Plant Savers Launches First Film Festival

    Roquette Launches Nutralys Rice Protein

    Upcycled Coffeeberry® Cascara Offers Versatility in Functional Beverage Development
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    CoQ10 and Royal Jelly Supplementation May Improve High Intensity Exercise

    Shiitake Mushroom Extract Appears Helpful in HPV Infections

    Fi & Hi Europe Returns with Over 20,000 Global Attendees Expected

    Azelis Opens Food and Nutrition Lab in Cairo, Egypt

    Florida Food Products Acquires Javo
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    CoQ10 and Royal Jelly Supplementation May Improve High Intensity Exercise

    Shiitake Mushroom Extract Appears Helpful in HPV Infections

    Upcycled Coffeeberry® Cascara Offers Versatility in Functional Beverage Development

    Botanical Gum for Kids Aims to Curb Sugar Cravings

    Combination of Collagen and Boswellia Serrata Shown to Reduce Joint Discomfort
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    Nutrition21, LLC

    Ecuadorian Rainforest

    Xsto Solutions

    Gencor

    Aiya America, Inc. (Aiya Matcha)
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    Nutrition21, LLC

    Ecuadorian Rainforest

    Xsto Solutions

    Gencor

    Aiya America, Inc. (Aiya Matcha)
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Breaking News

    Review Highlights Gut Microbiome’s Influence on CVD Risk Factors

    Several studies suggest that certain gut metabolites could ameliorate atherosclerosis, inflammation, obesity, insulin resistance, and more.

    Review Highlights Gut Microbiome’s Influence on CVD Risk Factors
    Related CONTENT
    • HMB Supplementation May Benefit Delayed-Onset Muscle Soreness
    • FrieslandCampina Ingredients Launches High-Purity Prebiotic Fiber
    • Research Trends in Nutrition and Mental Health
    • Aavishkar: Oral Films Poised for Success in Nutraceuticals Market
    • Health Products Association - China Executive Director Reflects on Market Dynamics, Challenges
    01.07.21
    A new review published in the journal Nutrients by Asim K. Duttaroy, a professor and group leader of Clinical Nutrition at the Faculty of Medicine in the University of Oslo, highlights a breadth of research which suggests that certain beneficial bacteria in the gut have a plethora of positive benefits to cardiovascular disease (CVD) risk factors.
     
    “Emerging data have demonstrated a strong association between the gut microbiota and the development of cardiovascular disease risk factors such as atherosclerosis, inflammation, obesity, insulin resistance, platelet hyperactivity, and plasma lipid abnormalities,” Duttaroy wrote.”
     
    A large part of the benefit stems from the metabolites sourced from certain gut microbes, he said, such as trimethylamine-N-oxide (TMAO), short-chain fatty acids, and bile acid metabolites (amino acid breakdown products), each of which is positively associated with better CVD outcomes.
     
    These metabolites are also associated with blood platelet activity, lipid disorders, and oxidative stress, leading Duttaroy to believe that the potential benefits which can be achieved by modulating the bacterial content in the gut are well worth investigating from a clinical perspective in the context of heart disease. Hyperactive platelets are of particular concern to Duttaroy as they have a role in hemostasis, thrombosis, and atherosclerosis – evidence suggests that platelet hyperactivity is more prevalent in people with diabetes, smokers, sedentary lifestyles, aging, obesity, certain gut metabolites, and an unhealthy diet.
     
    Atherosclerosis
    Duttaroy pointed to a number of clinical trials further substantiating the role that gut dysbiosis could have in the genesis of atherosclerosis. Inflammation could affect the integrity of a gut barrier, and maintaining a gut barrier’s integrity could be preventative toward inflammation in the atherosclerosis process, he said. One strain in particular, Akkermansia muciniphila, appears to exert notable protective effects toward gut barrier function, by increasing tight junction proteins, which are shown to fix intestinal permeability to prevent pro-inflammatory cytokines from permeating the digestive tract.
     
    One study in particular substantiated the cardiovascular risk that gut dysbiosis could pose. Duttaroy pointed to a number of animal studies which show that the varied effects of antibiotics could increase or decrease cardiac event risk in animal models of heart injury.
     
    Further, certain microbes are able to reduce circulating concentrations of TMAO, a compound which is associated with obesity, insulin resistance, renal disease, CVD on the whole, cardiovascular events, and atherosclerotic plaque size. This is because TMAO exacerbates inflammatory reactions of the vascular wall, and modulates cholesterol and sterol metabolism harmfully.
     
    Hypertension
    Studies on animal models show clearly that germ-free mice tend to be hypertensive – beyond this, the short-chain fatty acids that some bacteria produce, and their effect on LDL levels and other pathways are important to consider in the development of hypertension.
     
    “Dysbiosis can promote oxidation of LDL to oxLDL,” Duttaroy said. “Thus, gut dysbiosis also contributes to hypertension through vasoconstriction mediated by oxLDL. Higher levels of oxLDL contribute to hypertension by inhibiting nitric oxide synthesis and endothelin-1.”
     
    Platelet Hyperactivity
    “Apart from homeostasis, platelets are involved in several cardiovascular processes, including atherosclerosis, immune system, inflammation, interaction with other cells, and cardiac events,” Duttaroy said.
     
    TMAO, a metabolite produced by gut microbiota, has a clear and pronounced effect on the development of atherosclerosis and thrombotic events, Duttaroy said, pointing to in vitro studies which show that hyperactive platelets have a role in producing more reactive oxygen species, and decreasing NO availability. “Platelet hyperactivity plays a causal role in triggering and maintaining the pro-inflammatory and pro-thrombotic state of obesity, creating an environment favorable for atherothrombotic vascular events,” Duttaroy said.
     
    “Sufficient convincing data have emerged on the relationship between gut dysbiosis and CVD,” Duttaroy said. “However, further work is required for the establishment of gut microbiota-targeted therapy for CVD. Since various experimental and clinical data on the mechanisms of gut microbiota mediated-development of CVD are available, there is a strong possibility of finding new approaches to treat or prevent CVD.”
    Related Searches
    • Healthy Aging
    • Inflammation
    • Dietary Supplements
    • Digestive Health
    Related Knowledge Center
    • Healthcare Trends
    • Research
    • Probiotics & Prebiotics
    Suggested For You
    HMB Supplementation May Benefit Delayed-Onset Muscle Soreness HMB Supplementation May Benefit Delayed-Onset Muscle Soreness
    FrieslandCampina Ingredients Launches High-Purity Prebiotic Fiber FrieslandCampina Ingredients Launches High-Purity Prebiotic Fiber
    Research Trends in Nutrition and Mental Health Research Trends in Nutrition and Mental Health
    Aavishkar: Oral Films Poised for Success in Nutraceuticals Market Aavishkar: Oral Films Poised for Success in Nutraceuticals Market
    FDCA Preemption of State-Level Misbranding Laws for Structure/Function Ingredient Claims FDCA Preemption of State-Level Misbranding Laws for Structure/Function Ingredient Claims
    New and Evolving Formulation Options Must Be Mindful of Blood Sugar Maintenance New and Evolving Formulation Options Must Be Mindful of Blood Sugar Maintenance
    Health Products Association - China Executive Director Reflects on Market Dynamics, Challenges Health Products Association - China Executive Director Reflects on Market Dynamics, Challenges
    DSM and Firmenich to Merge to Create Nutrition, Beauty, and Wellness Brand DSM and Firmenich to Merge to Create Nutrition, Beauty, and Wellness Brand
    Thorne Relaunches Gut Health Test with Microbiome Wipe Thorne Relaunches Gut Health Test with Microbiome Wipe
    Danone Celebrates 10th Anniversary of Grant Program for Probiotics Research Danone Celebrates 10th Anniversary of Grant Program for Probiotics Research
    Vitafoods Europe 2022 Attendance Returns to 2019 Level Vitafoods Europe 2022 Attendance Returns to 2019 Level
    Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board Kyowa Hakko Appoints Dr. Colin Hill to Immuse Scientific Advisory Board
    Tocotrienols May Aid Weight Loss and Cognitive Performance, Animal Study Finds Tocotrienols May Aid Weight Loss and Cognitive Performance, Animal Study Finds
    Tocotrienols May Aid Weight Loss and Cognitive Performance, Animal Study Finds Tocotrienols May Aid Weight Loss and Cognitive Performance, Animal Study Finds
    A Postbiotic with Unmatched Clinical Research A Postbiotic with Unmatched Clinical Research

    Related Breaking News

    • Dietary Supplements | Research | Sports Nutrition
      HMB Supplementation May Benefit Delayed-Onset Muscle Soreness

      HMB Supplementation May Benefit Delayed-Onset Muscle Soreness

      The amino acid metabolite was tested in a population of 24 professional soccer players.
      06.10.22

    • Breaking News | Delivery & Dosage Technologies | Dietary Supplements | Digestive Health | Probiotics & Prebiotics | Supplier News
      FrieslandCampina Ingredients Launches High-Purity Prebiotic Fiber

      FrieslandCampina Ingredients Launches High-Purity Prebiotic Fiber

      The latest product in the Biotis profile contains 90% galacto-oligosaccharides.
      06.08.22

    • Cardiovascular Health | Mood Health & Sleep | Omega-3s | Probiotics & Prebiotics | Research | Weight Management/Weight Loss
      Research Trends in Nutrition and Mental Health

      Research Trends in Nutrition and Mental Health

      UKRI research fellow Dr. Joseph Firth discussed evidence supporting dietary habits and supplementation at Vitafoods Europe 2022.
      By Mike Montemarano, Associate Editor 06.06.22


    • Breaking News | Consumer Trends | Contract Manufacturing | Delivery & Dosage Technologies | Dietary Supplements | Supplier News | World Markets
      Aavishkar: Oral Films Poised for Success in Nutraceuticals Market

      Aavishkar: Oral Films Poised for Success in Nutraceuticals Market

      The patent-pending delivery system can carry a 60% active ingredient content.
      06.02.22

    • Consumer Trends | Dietary Supplements | Healthcare Trends | Regulations | World Markets
      Health Products Association - China Executive Director Reflects on Market Dynamics, Challenges

      Health Products Association - China Executive Director Reflects on Market Dynamics, Challenges

      China’s supplement market is growing at double digit levels. Jeff Crowther has the market intel to assist companies in capitalizing on emerging opportunities.
      By Sean Moloughney, Editor 06.02.22

    Loading, Please Wait..
    Trending
    • Three Grams Of Omega-3s May Be Optimal Dose For Reducing Blood Pressure
    • 3 grams of Omega-3s May be Optimal Dose for Reducing Blood Pressu
    • Olive/Pomegranate Extract May Improve Dyslipidemia
    • First Day Life Shuts Down Children's Behavioral, Cognitive Health Claims Following Challenge
    Breaking News
    • CoQ10 and Royal Jelly Supplementation May Improve High Intensity Exercise
    • Shiitake Mushroom Extract Appears Helpful in HPV Infections
    • Fi & Hi Europe Returns with Over 20,000 Global Attendees Expected
    • United Plant Savers Launches First Film Festival
    • Azelis Opens Food and Nutrition Lab in Cairo, Egypt
    View Breaking News >
    CURRENT ISSUE

    June 2022

    • Tapping Functional Beverages to Meet Modern Wellness Needs
    • Adaptogens: Where Ancient Remedies Meet Modern Wellness Products
    • New and Evolving Formulation Options Must Be Mindful of Blood Sugar Maintenance
    • Health Products Association - China Executive Director Reflects on Market Dynamics, Challenges
    • Blood Sugar Management: Personalized Testing Drives Home The Need for Early Intervention
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    CoQ10 and Royal Jelly Supplementation May Improve High Intensity Exercise
    Shiitake Mushroom Extract Appears Helpful in HPV Infections
    Fi & Hi Europe Returns with Over 20,000 Global Attendees Expected
    Coatings World

    Latest Breaking News From Coatings World

    H.M. Royal Becomes Exclusive OCSiAl Distributor
    American Colors to Expand Sandusky, Ohio Facility
    Vaughn O’Dea Named Director of Epoxytec
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    Cepheid, BioGX Partner to Create GeneXpert Monkeypox Test
    Siemens' Varian Gains FDA IDE Nod for FAST-02 Trial
    Acutus Medical Launches AcQCross Line Extension
    Contract Pharma

    Latest Breaking News From Contract Pharma

    Ixaka & Minaris Sign Tech Transfer & GMP Manufacturing Agreement for Cell Therapy Candidate
    Pfizer, BioNTech Adapt COVID Vax Against Omicron
    CoreRx Expands Capabilities
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Top 5 Beauty Tech Trends at Perfect Corp.'s Global Forum
    John Frieda Supports the LGBTQIA+ Community
    Athena Club Launches in Canada
    Happi

    Latest Breaking News From Happi

    Fencing Champion Bebe Vio Grandis Named Spokeswoman of L’Oréal Paris
    Past Henkel Exec Christian Chopra Named President of Scotch Porter
    Color Street Celebrates Foster, Adoption Awareness with Limited-Edition Print
    Ink World

    Latest Breaking News From Ink World

    Dr. Tammo Boinowitz to Join Management Board of ALTANA AG
    Flint Offset Packaging Solutions Announces Price Increases for Sheetfed Inks
    Weekly Recap: INX’s VC Fund, Screen Industry and Ball Top This Week’s News
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    Harveer Sahni recognized with Global Achievement Award
    Color-Logic partners with Taktiful 
    ALTANA announces Management Board change
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Fibertex Personal Care Awarded EcoVadis Awards for Sustainability
    Yanpai Orders Batt Forming Equipment for Needlepunch Line
    Weekly Recap: SWM and Neenah Introduce Mativ Inc., Avgol honored for Biotransformation Technology & More
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    Researchers Discover Novel Patching Material for Bone Defects
    Boston Centerless Opens Second Manufacturing Plant in Indiana
    Researchers Develop Patient-Specific 3D-Printed Smart Metamaterial Implants
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Identiv-Powered CVS Spoken Rx Wins NFC Forum 2022 Innovation Award
    LG Display Announces Winners of This Year’s OLEDs GO! Competition
    Weekly Recap: eMagin, Applied Materials, and Schott Top This Week’s Stories

    Copyright © 2022 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login