• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Contract Manufacturing: Trials & Tribulations of Today’s Supply Chains

    Analytical Testing in Nutraceuticals: Methods and Mindsets to Uphold Quality

    Nutrition and Flavor: Formulating for Modern Product Preferences

    What Do Consumers Know About the Gut Microbiome?

    How Will the European Green Deal Impact Dietary Supplements?
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process

    ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market

    Tazo Transitions to Regenerative Organic Agriculture

    Protein Ingredient Formulated for Chronic Kidney Disease Patients

    IADSA Calls for Addressing Discrepancies in Vitamin C Recommendations
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    Fact or Myth: Antioxidants Negatively Impact Iron Absorption

    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process

    ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market

    Tazo Transitions to Regenerative Organic Agriculture

    Protein Ingredient Formulated for Chronic Kidney Disease Patients
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    Fact or Myth: Antioxidants Negatively Impact Iron Absorption

    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process

    ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market

    Tazo Transitions to Regenerative Organic Agriculture

    Protein Ingredient Formulated for Chronic Kidney Disease Patients
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process

    Caffeine-Free Energy Supplement Linked to Alertness, Fatigue Benefits

    Monk Fruit Sweetener May Have Prebiotic Activity, Study Finds

    People with Low-Fiber Diets Benefit the Most from Fiber Supplements, Study Finds

    Gut Microbiome May Be Part of Link Between Red Meat and Heart Disease Risk
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    Sabinsa Corporation

    Nutrition21, LLC

    PhytoGaia Inc

    Bioenergy Life Science, Inc. (BLS)

    Botanic Healthcare LLC
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    Sabinsa Corporation

    Nutrition21, LLC

    PhytoGaia Inc

    Bioenergy Life Science, Inc. (BLS)

    Botanic Healthcare LLC
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Breaking News

    Do Optimal Vitamin D Levels Impact Cancer Risk?

    Researchers made the case that vitamin D’s homeostatic impact on immune function may contribute to cancer prevention.

    Do Optimal Vitamin D Levels Impact Cancer Risk?
    Research evaluating vitamin D's possible protective effect against cancer dates back decades.
    Related CONTENT
    • Organic & Natural Health Association Launches Vitamin D Campaign
    • Vitamin D May Help Reduce Recurrence of Vertigo
    • Large-Scale Study Finds No Link Between Vitamin D and Depression Risk
    • Earthlight Whole Food Vitamin D Receives Additive Petition Approval in U.S.
    • CAIF Launches Acerola Powder Extract with Minimum 32% Native Vitamin C
    06.30.20
    In a review published in the journal Cancer Biology, researchers suggested that there could be an optimal level of vitamin D that can be attained in order to fight against a number of various cancers, including colon, breast, prostate, and hematological cancers, which are known to occur at higher frequencies among populations with a low vitamin D status.
     
    The most active vitamin D metabolite is responsible for a biological mechanism targeting approximately 1,000 target genes in a large proportion of human tissues and cell types. The primary role of vitamin D is believed to be the control of energy metabolism later shifting to modulate innate and adaptive immunity, as well as to regulate calcium and bone homeostasis.
     
    The authors believe that the properties of vitamin D associated with immune function and anti-cancer are linked because vitamin D signaling is associated with both of the genetic pathways used by immune and cancer cells to proliferate.  
     
    “Since rapidly growing immune and cancer cells both use the same pathways and genes for controlling their proliferation, differentiation, and apoptosis, not surprisingly, vitamin D signaling changes these processes also in neoplastic cells,” the authors wrote. “Thus, anti-cancer effects of vitamin D may derive from managing growth in differentiation and immunity.”
     
    Evidence that vitamin D may hold anti-cancer benefits dates back to 40 years ago, when the first epidemiological study of its kind suggested that vitamin D may protect against colorectal cancer, due to the fact that scientists at the time linked increased sun exposure to a lower incidence of this type of cancer. Follow-up intervention trials further discovered that vitamin D, from an observational level, appeared to mitigate the risk of other types cancers, as well.
     
    VITAL, a randomized controlled trial that enrolled over 25,000 participants with a history of cancer, evaluated the effects of supplementing with 2000 IU of vitamin D daily in an effort ot prevent cancer. While the primary analysis did not report a significant risk reduction, a secondary analysis suggested a benefit after excluding early follow-up data and subgroups of individuals in cancer incidence and/or mortality. Three follow-up trials also observed a statistical benefit, the authors wrote.
     
    The authors also included in their meta-analysis a breakdown of the plethora of cancers which vitamin D may play an active role in preventing, and the extent to which researchers have begun to understand the mechanisms by which this is possible, through its ability to repress immune cells and the carcinomas which proliferate through the same genetic pathways, and that cancers with a number of pathological and genetic subtypes will pose the greatest challenge to further research.
     
    They’ve stated that there is a need for more research into the mechanistic link between vitamin D and colorectal cancer, breast cancer, prostate cancer (which they said was a less compelling case), hematological malignancies such as leukemias, lymphomas, and multiple myeloma (which often show poorer prognoses in those with low vitamin D status), and more.
     
    “Epigenomic and transcriptomic analyses as well as numerous experimental studies in a variety of cancer systems provided large sets of strong data that jointly indicate a protective action of vitamin D signaling against several types of cancer,” the authors concluded. “Most convincing molecular data exist for CRC [colorectal carcinoma] and AML [acute myeloid leukemia]. This results from the regulation of a high number of genes that control the proliferation, survival, differentiation, migration, and communication of cancer cells and stromal cells, such as fibroblasts, adipocytes, immune, and endothelial cells. Conceivably, the lack of concordant positive clinical data in large randomized controlled trials may be due to a lack of sub-analysis of disease cohorts as well as short follow-up.”
     
    “Vitamin D is a major regulator of signaling in human cells, which displays a long list of protective homeostatic effects in cultured cells and animal models of cancer. Thus, it contributes to maintain and defend the normal physiology of the organism against the apparition and development of neoplasias.”
     
     
     
    Related Searches
    • Cancer Risk
    • Research
    • Vitamins
    • Dietary Supplements
    Related Knowledge Center
    • Medical Nutrition
    • Dietary Supplements
    • Vitamins
    Suggested For You
    Organic & Natural Health Association Launches Vitamin D Campaign Organic & Natural Health Association Launches Vitamin D Campaign
    Vitamin D May Help Reduce Recurrence of Vertigo Vitamin D May Help Reduce Recurrence of Vertigo
    Large-Scale Study Finds No Link Between Vitamin D and Depression Risk Large-Scale Study Finds No Link Between Vitamin D and Depression Risk
    Earthlight Whole Food Vitamin D Receives Additive Petition Approval in U.S. Earthlight Whole Food Vitamin D Receives Additive Petition Approval in U.S.
    CAIF Launches Acerola Powder Extract with Minimum 32% Native Vitamin C CAIF Launches Acerola Powder Extract with Minimum 32% Native Vitamin C
    Vitamin K1 Deficiency Associated with All-cause Mortality, but Not CVD  Vitamin K1 Deficiency Associated with All-cause Mortality, but Not CVD
    The Link Between Vitamin D Deficiency and COVID-19 Mortality The Link Between Vitamin D Deficiency and COVID-19 Mortality
    ChromaDex Highlights The Latest Research on Niagen ChromaDex Highlights The Latest Research on Niagen
    An Interview with Douglas Wyatt, Founder, Sovereign Laboratories An Interview with Douglas Wyatt, Founder, Sovereign Laboratories
    Study Links Low Vitamin K Levels to Severity in COVID-19 Outcomes Study Links Low Vitamin K Levels to Severity in COVID-19 Outcomes
    The Latest in Vitamin D Research The Latest in Vitamin D Research
    Are you getting enough essential Vitamin E? Are you getting enough essential Vitamin E?

    Related Breaking News

    • Breaking News | Consumer Trends | Dietary Supplements | Healthcare Trends | Immune Function | Industry & Market News | Medical Nutrition | Vitamins
      Organic & Natural Health Association Launches Vitamin D Campaign

      Organic & Natural Health Association Launches Vitamin D Campaign

      The education initiative aims to inform consumers at the greatest risk of vitamin D deficiency with relevant research.
      08.17.20

    • Breaking News | Research | Research News | Vitamins
      Vitamin D May Help Reduce Recurrence of Vertigo

      Vitamin D May Help Reduce Recurrence of Vertigo

      There appears to be greater benefit for those who are more deficient in vitamin D.
      08.10.20

    • Breaking News | Dietary Supplements | Medical Nutrition | Mood Health & Sleep | Research | Research News | Vitamins
      Large-Scale Study Finds No Link Between Vitamin D and Depression Risk

      Large-Scale Study Finds No Link Between Vitamin D and Depression Risk

      Thousands of participants were administered high doses of vitamin D3, which did not impact clinical outcomes or scores on yearly mood assessments.
      08.07.20


    • Consumer Trends | Functional Foods & Beverages | Immune Function | Natural/Organic | Vitamins
      Earthlight Whole Food Vitamin D Receives Additive Petition Approval in U.S.

      Earthlight Whole Food Vitamin D Receives Additive Petition Approval in U.S.

      The clean-label, plant-based ingredient can now be used to fortify foods in 18 different categories.
      07.15.20

    • Antioxidants | Breaking News | Consumer Trends | Contract Manufacturing | Dietary Supplements | Functional Foods & Beverages | Immune Function | Inflammation | Natural/Organic | Supplier News | Vitamins | World Markets
      CAIF Launches Acerola Powder Extract with Minimum 32% Native Vitamin C

      CAIF Launches Acerola Powder Extract with Minimum 32% Native Vitamin C

      The high-potency ingredient can be used in supplements, beverages, and snacks.
      07.01.20

    Loading, Please Wait..
    Trending
    • Study Examines Vitamin K2 Content In Cheese
    • Chenland Nutritionals Self-Affirms GRAS For Cumin UP60 Ingredient
    • Pycnogenol Evidenced To Have Skin Benefits In Dermatology Study
    • ADM And Benson Hill Partner To Scale High Protein Soy For U.S. Market
    Breaking News
    • Charlotte’s Web Sports Product Line to Undergo NSF Certification Process
    • ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market
    • Tazo Transitions to Regenerative Organic Agriculture
    • Protein Ingredient Formulated for Chronic Kidney Disease Patients
    • IADSA Calls for Addressing Discrepancies in Vitamin C Recommendations
    View Breaking News >
    CURRENT ISSUE

    July/August 2022

    • A Growing Herbal Products Market Still Faces Formidable Threats, Challenges
    • Analytical Testing in Nutraceuticals: Methods and Mindsets to Uphold Quality
    • Nutrition and Flavor: Formulating for Modern Product Preferences
    • Contract Manufacturing: Trials & Tribulations of Today’s Supply Chains
    • How Will the European Green Deal Impact Dietary Supplements?
    • What Do Consumers Know About the Gut Microbiome?
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process
    ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market
    Tazo Transitions to Regenerative Organic Agriculture
    Coatings World

    Latest Breaking News From Coatings World

    What are you Reading this Week?
    SONGWON Industrial Group Reports Strong Q2 Financial Results
    PPG Completes COLORFUL COMMUNITIES Project for Boys & Girls Clubs of Greater Houston
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    MPO's Most-Read Stories This Week—Aug. 13
    'Graft-on-a-Chip' Built to Improve Vascular Graft Success
    Abbott Invests €440 in New Irish Facility
    Contract Pharma

    Latest Breaking News From Contract Pharma

    AskBio Appoints Clinical Ops Executives
    SpectrumX Partners With UK Contract Manufacturer
    GL Chemtec Partners with Edgewater Capital to Accelerate Growth
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Arkay Chairman Emeritus Howard Kaneff Has Died
    Nutricosmetics Market to Hit $13.7 Billion by 2030
    Estée Lauder Pledges 100% Electric Fleet of Vehicles by 2030
    Happi

    Latest Breaking News From Happi

    Consumers are Clamoring for Vintage Glam: Spate
    Kayali’s Lovefest Fragrance, Newell’s New Candle and HydraFacial’s Record Financial Results
    Self Care Trumps Home Care Post-Covid
    Ink World

    Latest Breaking News From Ink World

    Weekly Recap: Printing Ink Primer, Zeller+Gmelin Lead This Week’s News Stories
    Heidelberg Enjoys Successful Start to 2022-23 Fiscal Year
    Mimaki Announces New LATAM Website
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    Esko, Constantia Flexibles announce acquisitions and more
    Hybrid Software joins The Flexo Xperience Center
    Flexo Wash LLC and Mike Potter celebrate 20 years
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Weekly Recap: Essity Switches to Recyclable Packs for Feminine Pads, FTC Sues PPE Maker on False Origin Claims & More
    Focke & Co. to Host Destination: Your Hygiene Hub on August 31
    Exports Dominate Chinese Trade of Tissues, Hygiene Products and Wipes
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    ODT's Most-Read Stories This Week—Aug. 13
    Dental 3D Printing Market is Expanding 20% Annually
    Study Results Released for Abbott's Concussion Blood Test
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Weekly Recap: ALTANA, Universal Display and Emerson Top This Week’s Stories
    eMagin Corporation Announces 2Q 2022 Results
    Zebra Technologies’ Emission Reduction Targets Validated by SBTi

    Copyright © 2022 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login