• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Contract Manufacturing: Trials & Tribulations of Today’s Supply Chains

    Analytical Testing in Nutraceuticals: Methods and Mindsets to Uphold Quality

    Nutrition and Flavor: Formulating for Modern Product Preferences

    What Do Consumers Know About the Gut Microbiome?

    How Will the European Green Deal Impact Dietary Supplements?
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Research
    Supplier News
    Supplier Insights
    Live From Shows
    Top News
    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process

    ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market

    Tazo Transitions to Regenerative Organic Agriculture

    Protein Ingredient Formulated for Chronic Kidney Disease Patients

    IADSA Calls for Addressing Discrepancies in Vitamin C Recommendations
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    Fact or Myth: Antioxidants Negatively Impact Iron Absorption

    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process

    ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market

    Tazo Transitions to Regenerative Organic Agriculture

    Protein Ingredient Formulated for Chronic Kidney Disease Patients
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    Fact or Myth: Antioxidants Negatively Impact Iron Absorption

    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process

    ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market

    Tazo Transitions to Regenerative Organic Agriculture

    Protein Ingredient Formulated for Chronic Kidney Disease Patients
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process

    Caffeine-Free Energy Supplement Linked to Alertness, Fatigue Benefits

    Monk Fruit Sweetener May Have Prebiotic Activity, Study Finds

    People with Low-Fiber Diets Benefit the Most from Fiber Supplements, Study Finds

    Gut Microbiome May Be Part of Link Between Red Meat and Heart Disease Risk
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    Verdure Sciences

    Atlantia Clinical Trials

    BGG World

    PhytoGaia Inc

    Aiya America, Inc. (Aiya Matcha)
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    Verdure Sciences

    Atlantia Clinical Trials

    BGG World

    PhytoGaia Inc

    Aiya America, Inc. (Aiya Matcha)
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • Infographics
    • eBook
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Breaking News

    Plant-Rich Diet Shown to Protect Mice from Pathogens

    Research is another step in defining the molecular mechanisms that govern how the gut impacts the virulence of intestinal pathogens.

    Related CONTENT
    • Ketogenic Diet May Fuel Immune System to Fight Flu Virus
    • Animal study Demonstrates Cardioprotective Benefits of Sabinsa’s Pterostilbene
    • Vitamin K2 as MK-7 Shown to Improve Endothelial Function
    • Sabinsa Founder Debuts New Book on Curucmin & Metabolites
    • An Interview with Manoj Dadlani, CEO, CosmosID
    01.03.20
    Mice fed a plant-rich diet were less susceptible to gastrointestinal (GI) infection from a pathogen such as E. coli, according to research published in Nature Microbiology.
     
    “There has been a lot of hearsay about whether a plant-based diet is better for intestinal health than a typical Western diet, which is higher in oils and protein but relatively low in fruits and vegetables,” said Vanessa Sperandio, PhD, professor of microbiology and biochemistry at UT Southwestern, which led the study. “So we decided to test it.”
     
    “Plant-rich diets are high in pectin, a gel-like substance found in many fruits and vegetables,” she added. “Pectin is digested by the gut microbiota into galacturonic acid, which we find can inhibit the virulence of EHEC,” which is a strain of E. coli.
     
    “This is relevant to public health because EHEC outbreaks lead to hemorrhagic colitis, which is debilitating and sometimes causes death, particularly in the very young and the elderly,” she noted.
     
    Intestinal pathogens like EHEC sense the complex chemistry inside the GI tract to compete with the gut’s resident microbiota to establish a foothold, Sperandio said. Over centuries, the pathogens have developed different strategies to compete against the so-called good, or commensal, microbes that normally line the gut.
     
    Those commensals include harmless strains of E. coli living in the colons of humans and other mammals, where they help the host’s normal digestion process. The word commensal means “eating at the same table” and that is what the symbiotic bacteria that make up the gut’s microbiota do.
     
    The commensals that line the gut present a significant barrier to intestinal pathogens, Sperandio said. EHEC and similar gram-negative bugs overcome that barrier by deploying a secretion system called T3SS.
     
    T3SSs act like molecular syringes to inject a mix of virulence proteins into the cells lining the host’s colon, setting off inflammation and symptoms of infection. Because mice are unaffected by EHEC, researchers use a similar pathogen, Citrobacter rodentium, in mouse studies.
     
    “Our study finds first that the good E. coli and the pathogenic ones like EHEC use different sugars as nutrients,” said Sperandio, adding that the two types of E. coli may have evolved to avoid competing for the same energy sources. “Second, we find that dietary pectin protects against the pathway the pathogenic EHEC uses to become more virulent.”
     
    Another type of commensal gut bacteria breaks down dietary pectin from fruit and vegetables, creating galacturonic acid, a sugar acid that the EHEC and C. rodentium use in two ways. Initially, the pathogen uses that sugar acid as an energy source to expand in the gut, Sperandio said.
     
    “Once the sugar acid becomes depleted, the pathogen changes its survival strategy, almost like flipping a switch,” she said. Instead of using the galacturonic acid for nourishment, the infectious bacteria employs it in a signaling pathway that increases the EHEC’s and similar bacteria’s virulence using the syringe-like T3SS.
     
    In the study, mice fed pectin for about a week withstood infection. Comparing the colons of six mice fed a chow diet with 5% extra pectin from citrus peel with four mice on a typical diet, the researchers found a much lower rate of infection in the pectin-eating mice.
     
    The amount of bacteria in the mouse gut was measured by daily stool checks and by analysis of the amount of bacteria in a pouch at the juncture of the small and large intestines, called the cecum, at the experiment’s end.
     
    The researchers found that mice on the pectin-enriched chow had about 10,000 bacteria in the cecum compared to 1 million bacteria in mice on the typical diet. The pectin group also had fewer symptoms. A pectin level of 5% appears to prevent the pathogen from activating its virulence repertoire.
     
    The research is one step in a journey to define the molecular mechanisms that govern how the commensal species in the gut impact the virulence of intestinal pathogens.
     
    “This is not translatable to humans yet,” said Sperandio. “We hope a better understanding of how intestinal disease develops will lead to strategies to reduce the incidence or, at least, the symptoms caused by these gram-negative pathogens, possibly through new vaccines or drugs.”
    Related Searches
    • microbiota
    • Vegetables
    • Research
    • Digestion
    Related Knowledge Center
    • Research
    Suggested For You
    Ketogenic Diet May Fuel Immune System to Fight Flu Virus Ketogenic Diet May Fuel Immune System to Fight Flu Virus
    Animal study Demonstrates Cardioprotective Benefits of Sabinsa’s Pterostilbene Animal study Demonstrates Cardioprotective Benefits of Sabinsa’s Pterostilbene
    Vitamin K2 as MK-7 Shown to Improve Endothelial Function Vitamin K2 as MK-7 Shown to Improve Endothelial Function
    Sabinsa Founder Debuts New Book on Curucmin & Metabolites Sabinsa Founder Debuts New Book on Curucmin & Metabolites
    An Interview with Manoj Dadlani, CEO, CosmosID An Interview with Manoj Dadlani, CEO, CosmosID
    Prebiotics Help Build a Healthy Microbiome & Immune System Prebiotics Help Build a Healthy Microbiome & Immune System
    Nutrigenomics Expert Christine Houghton Endorses HK L-137 Nutrigenomics Expert Christine Houghton Endorses HK L-137
    Researchers Discover Gut & Satiety Hormones Influence Weight Gain Researchers Discover Gut & Satiety Hormones Influence Weight Gain
    Whole-Food Based Dietary Approach Benefits Crohn’s Disease Patients Whole-Food Based Dietary Approach Benefits Crohn’s Disease Patients
    Diet Quality Linked to Microbiome Composition Diet Quality Linked to Microbiome Composition
    Tomorrow’s Nutrition Debuts Natural Products to Support Urinary Tract Health Tomorrow’s Nutrition Debuts Natural Products to Support Urinary Tract Health
    Pesticide Exposure Linked to Teen Depression in Agricultural Communities Pesticide Exposure Linked to Teen Depression in Agricultural Communities
    Short Bout of Exercise May Enhance Brain Function Short Bout of Exercise May Enhance Brain Function

    Related Breaking News

    • Breaking News | Healthcare Trends | Immune Function | Industry & Market News | Research
      Ketogenic Diet May Fuel Immune System to Fight Flu Virus

      Ketogenic Diet May Fuel Immune System to Fight Flu Virus

      In a mouse study, keto diet triggered the release of gamma delta T cells, immune system cells that produce mucus in the cell linings of the lung.
      11.19.19

    • Antioxidants | Breaking News | Cardiovascular Health | Herbs & Botanicals | Research | Research News | Supplier News
      Animal study Demonstrates Cardioprotective Benefits of Sabinsa’s Pterostilbene

      Animal study Demonstrates Cardioprotective Benefits of Sabinsa’s Pterostilbene

      Silbinol led to reduction of TMAO formation and decreased vascular inflammation.
      11.19.19

    • Breaking News | Cardiovascular Health | Research | Research News | Supplier News | Vitamins

      Vitamin K2 as MK-7 Shown to Improve Endothelial Function

      MenaQ7 mouse study advances argument of K2 as MK-7 as a cardio-protective nutrient by highlighting new pharmacological activity.
      11.15.19


    • Breaking News | Herbs & Botanicals | Research | Supplier News
      Sabinsa Founder Debuts New Book on Curucmin & Metabolites

      Sabinsa Founder Debuts New Book on Curucmin & Metabolites

      The book is a compilation of the pharmacological activities of four reduced curcuminoids.
      10.14.19

    • Dietary Supplements | Digestive Health | Healthcare Trends | Probiotics & Prebiotics | Testing
      An Interview with Manoj Dadlani, CEO, CosmosID

      An Interview with Manoj Dadlani, CEO, CosmosID

      Dadlani is CEO of the Maryland-based provider of industry-leading solutions for unlocking the microbiome.
      By Sheldon Baker 10.07.19

    Loading, Please Wait..
    Trending
    • First Day Life Shuts Down Children's Behavioral, Cognitive Health Claims Following Challenge
    • Study Examines Vitamin K2 Content In Cheese
    • Chenland Nutritionals Self-Affirms GRAS For Cumin UP60 Ingredient
    • Pycnogenol Evidenced To Have Skin Benefits In Dermatology Study
    • ADM And Benson Hill Partner To Scale High Protein Soy For U.S. Market
    Breaking News
    • Charlotte’s Web Sports Product Line to Undergo NSF Certification Process
    • ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market
    • Tazo Transitions to Regenerative Organic Agriculture
    • Protein Ingredient Formulated for Chronic Kidney Disease Patients
    • IADSA Calls for Addressing Discrepancies in Vitamin C Recommendations
    View Breaking News >
    CURRENT ISSUE

    July/August 2022

    • A Growing Herbal Products Market Still Faces Formidable Threats, Challenges
    • Analytical Testing in Nutraceuticals: Methods and Mindsets to Uphold Quality
    • Nutrition and Flavor: Formulating for Modern Product Preferences
    • Contract Manufacturing: Trials & Tribulations of Today’s Supply Chains
    • How Will the European Green Deal Impact Dietary Supplements?
    • What Do Consumers Know About the Gut Microbiome?
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Charlotte’s Web Sports Product Line to Undergo NSF Certification Process
    ADM and Benson Hill Partner to Scale High Protein Soy for U.S. Market
    Tazo Transitions to Regenerative Organic Agriculture
    Coatings World

    Latest Breaking News From Coatings World

    SONGWON Industrial Group Reports Strong Q2 Financial Results
    PPG Completes COLORFUL COMMUNITIES Project for Boys & Girls Clubs of Greater Houston
    Paul N. Gardner Now Offers Bacharach Sling Psychrometer
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    'Graft-on-a-Chip' Built to Improve Vascular Graft Success
    Abbott Invests €440 in New Irish Facility
    FDA Approves Guardant Health's NGS-Based Companion Diagnostic
    Contract Pharma

    Latest Breaking News From Contract Pharma

    AskBio Appoints Clinical Ops Executives
    SpectrumX Partners With UK Contract Manufacturer
    GL Chemtec Partners with Edgewater Capital to Accelerate Growth
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Arkay Chairman Emeritus Howard Kaneff Has Died
    Nutricosmetics Market to Hit $13.7 Billion by 2030
    Estée Lauder Pledges 100% Electric Fleet of Vehicles by 2030
    Happi

    Latest Breaking News From Happi

    J&J To Stop Global Sales of Talc-Based Products by 2023
    Net Sales Increase 2% for Naples Soap Company in Second Quarter
    Net Revenue Down 12% for Grove Collaborative in Second Quarter
    Ink World

    Latest Breaking News From Ink World

    Heidelberg Enjoys Successful Start to 2022-23 Fiscal Year
    Mimaki Announces New LATAM Website
    Paul N. Gardner Offers Bacharach Sling Psychrometer
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    Esko, Constantia Flexibles announce acquisitions and more
    Hybrid Software joins The Flexo Xperience Center
    Flexo Wash LLC and Mike Potter celebrate 20 years
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Focke & Co. to Host Destination: Your Hygiene Hub on August 31
    Exports Dominate Chinese Trade of Tissues, Hygiene Products and Wipes
    Freudenberg to Present Friction Inserts for Wind Energy
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    Dental 3D Printing Market is Expanding 20% Annually
    Study Results Released for Abbott's Concussion Blood Test
    Bone Growth Stimulators Market to Top $3B by 2030
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    eMagin Corporation Announces 2Q 2022 Results
    Zebra Technologies’ Emission Reduction Targets Validated by SBTi
    Identiv Delivers Impressive 41% Year-over-Year Growth in RFID Business

    Copyright © 2022 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login