Seipel Group has registered the U.S. trademark Urox for the formula, a proprietary blend of Lindera aggregata, Equisetum arvense and Cratevox (Crateva nurvala), which is sold by several U.S. supplement companies under their own brands.
Developed by Tracey Seipel, N.D., a Naturopathic clinician and herbalist who has been combining traditional and scientific theories to develop treatment strategies and formulations since 1987, the Urox formula was developed through years of research into the prevalence and impact of bladder control issues for both men and women, which affects up to 50 million Americans.
One of the studies on the formula was the subject of a poster presentation at the 17th International Conference of the Functional Food Center in the Functional and medical foods with bioactive compounds for the management of chronic diseases session: The effect of UroxTM (Crateva, Horsetail and Lindera herbal combination) in the treatment of overactive bladder and urinary incontinence: A randomized, double-blind, placebo-controlled trial in men and women.The investigation clearly demonstrated both statistical significance and clinical relevance in relation to Urox reducing bladder symptoms such as urinary frequency, urinary urgency, nocturia and urinary incontinence in as little as two weeks.
The Queensland, Australia State Government saw that Seipel’s work could potentially change the face of aging given that urinary incontinence is one of the leading causes for the elderly being admitted to nursing care. They funded a 120-participant randomized controlled trial on Seipel’s earlier formula in 2004-2006. The research was conducted in the U.S. at Sphera Research Institute, headed up by Dr. Gene Spiller. Seipel has since revised the formula to show benefits in a shorter time period, which is the patented formula.