The brain is the master regulatory organ that directly or indirectly controls the function of all the other organs and tissues in the body. Any dysfunctions in the brain eventually have an effect on other body functions. The human brain controls the central nervous system, the peripheral nervous system and regulates almost all human activity.(1)
The combination of high fat content and low antioxidant levels in the brain makes the brain vulnerable to fatty acid oxidation, called lipid peroxidation. Most degenerative diseases of the brain can be traced back to lipid peroxidation.(2)
Alzheimer's disease is characterized by the presence of oxidized protein called amyloid beta peptide. There is a direct association between amyloid beta peptide formation and lipid peroxidation. Furthermore, amyloid beta peptide causes further damage to brain cells by causing further lipid peroxidation which produces more 4-hydroxynonenyl, a neurotoxic agent and which inhibits glucose uptake by brain cells.(2)
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