Introduction
The objective of this Technical Information is to demonstrate the effect of viscosity of the selected wet binder on the tableting per- formance and dissolution of naproxen immediate release tablets. Povidones are available in different molecular weights. The higher the molecular weight, the greater the viscosity and consequently the adhesive strength. The K-value denotes the intrinsic viscosity of the polymer related to the molecular weight, and is derived from the relative viscosity of the aqueous solution measured at 25°C. The direct correlation between the molecular weight and proper- ties enables the appropriate grade to be used in each formulation in the appropriate concentration in order to achieve the optimum effect. In order to provide formulators with flexibility in the choice of wet granulation binders with good adhesive strength and ease of han- ding, JRS PHARMA offers 2 grades of wet binders: VIVAPHARM® PVP K30 and VIVAPHARM® PVP K25.
The objective of this Technical Information is to demonstrate the effect of viscosity of the selected wet binder on the tableting per- formance and dissolution of naproxen immediate release tablets. Povidones are available in different molecular weights. The higher the molecular weight, the greater the viscosity and consequently the adhesive strength. The K-value denotes the intrinsic viscosity of the polymer related to the molecular weight, and is derived from the relative viscosity of the aqueous solution measured at 25°C. The direct correlation between the molecular weight and proper- ties enables the appropriate grade to be used in each formulation in the appropriate concentration in order to achieve the optimum effect. In order to provide formulators with flexibility in the choice of wet granulation binders with good adhesive strength and ease of han- ding, JRS PHARMA offers 2 grades of wet binders: VIVAPHARM® PVP K30 and VIVAPHARM® PVP K25.