Abstract
Roller compaction, or dry granulation, is a manufacturing method for pharmaceutical and nutraceutical tablets that continues to gain importance. In order to achieve the desired granule properties, it is vital to use efficient binder-filler systems, which enable easy compaction, reproducible grinding results, and high re-compactibility during the final tableting step.
In this study, microscrystalline cellulose (VIVAPUR 101), as well aas two grades of silicified microcrystalline cellulose (PROSOLV SMCC 50 and PROSOLV SMCC 50LD) were tested in regards to their performance as roller compaction binders.
All three binders were found to be highly efficient in roller compaction. Differences in their powder characteristics translated into modification of the resulting granule properties. Proper selection of the initial microcrystalline cellulose (MCC) or silicified microcrystalline cellulose (SMCC) material can, therefore, be used to fine-tune the granules in terms of their flowability, particle size, and tabletability.
In this study, microscrystalline cellulose (VIVAPUR 101), as well aas two grades of silicified microcrystalline cellulose (PROSOLV SMCC 50 and PROSOLV SMCC 50LD) were tested in regards to their performance as roller compaction binders.
All three binders were found to be highly efficient in roller compaction. Differences in their powder characteristics translated into modification of the resulting granule properties. Proper selection of the initial microcrystalline cellulose (MCC) or silicified microcrystalline cellulose (SMCC) material can, therefore, be used to fine-tune the granules in terms of their flowability, particle size, and tabletability.