Clumpy or poor flowing powders are difficult to transport and dose. Homogeneous mixing with active pharmaceutical ingredients (APIs) and other ingredients is compromised when caking, sticking (to walls), or electrostatic conditions occur.
The addition of small amounts (0.2-2%) of SYLOID® FP silica can improve flow properties of formulations. The controlled porous morphology of SYLOID® FP silica can create unique interactions, charges, and capillary forces resulting in improved free-flow, glidants, and anti-caking behaviors.
SYLOID® 244FP, AL-1FP (EU), and 63FP (US) excipients are synthetic and amorphous silicas. They are produced under controlled conditions, guaranteeing high chemical purity. Grace is the manufacturer of SYLOID® FP silicas facilitating supply chain custody and traceability. SYLOID® FP silicas are certified to meet the specific test requirements as published in the latest editions of the United States Pharmacopoeia- National Formulatory (USP-NF) for Silicon Dioxide, Japanese Pharmaceutical Excipients (JPE) for Hydrated Silicon Dioxide and the European Pharmacopoeia (EP) for Colloidal Hydrated Silica.
Characteristics of ingredients, how they interact with each other, and the surfaces they come in contact with, and various environmental factors can all affect flow behavior. Common flow challenges include caking, sticking, and static behavior. This is illustrated in the graph below, where the force required to get a powder to move is compared to the moving speed of the powder.
The addition of small amounts (0.2-2%) of SYLOID® FP silica can improve flow properties of formulations. The controlled porous morphology of SYLOID® FP silica can create unique interactions, charges, and capillary forces resulting in improved free-flow, glidants, and anti-caking behaviors.
SYLOID® 244FP, AL-1FP (EU), and 63FP (US) excipients are synthetic and amorphous silicas. They are produced under controlled conditions, guaranteeing high chemical purity. Grace is the manufacturer of SYLOID® FP silicas facilitating supply chain custody and traceability. SYLOID® FP silicas are certified to meet the specific test requirements as published in the latest editions of the United States Pharmacopoeia- National Formulatory (USP-NF) for Silicon Dioxide, Japanese Pharmaceutical Excipients (JPE) for Hydrated Silicon Dioxide and the European Pharmacopoeia (EP) for Colloidal Hydrated Silica.
Characteristics of ingredients, how they interact with each other, and the surfaces they come in contact with, and various environmental factors can all affect flow behavior. Common flow challenges include caking, sticking, and static behavior. This is illustrated in the graph below, where the force required to get a powder to move is compared to the moving speed of the powder.
