Pharmactive Biotech has launched CSAT+, a unique, bioactive blend of carob bean extracts which have been shown to have a synergistic effect in two animal studies. The two studies, one published last April, showed positive metabolic effects from supplementation with the novel, patent-pending carob fruit ingredient.
 
Metabolic syndrome is a combination of health factors including high blood pressure, high blood sugar and insulin, elevated triglycerides, low HDL cholesterol, and obesity. It often leads to a cluster of disease states, including type 2 diabetes, liver disease, angina, cardiovascular disease, and other types of disorders.
 
Carob, an ancient pod fruit grown throughout the Mediterranean and is mentioned often in the Bible, is rich in soluble fibers, and other antioxidant compounds known as polyphenols. CSAT+ has been previously determined to aid in limiting excessive calorie consumption, reducing unhealthy eating habits, and prolonging the feeling of satiety.
 
In the most recent study, published in the journal Antioxidants, researchers analyzed the effects of CSAT+ on the cardiometabolic alterations associated with metabolic syndrome in mice. The results of this study found that the carod extract was able ot reduce blood glucose, lower insulin resistance, improve blood levels of total cholesterol and LDL cholesterol, and improve the inflammatory marker known as interleukin-6 based on blood samples. An analysis of adipose tissue and skeletal muscle showed that CSAT+ prevented metabolic syndrome-induced insulin resistance, reduced pro-inflammatory markers, and improved levels of antioxidant markers.
 
Supplementation with CSAT+ also appeared to prevent metabolic syndrome-induced hypertension, while attentuating endothelial dysfunction and increasing vascular sensitivity to insulin. In the heart tissues of micce, the CSAT+ group exhibited reduced muscle cell death and prevented decrease in cardiac contractility as associated with a lower expression of pro-inflammatory and oxidative free radical markers in both the heart and the aorta.
 
Previous studies revealed that CSAT+ can act as natural support for weight management. It combines satiating effects with an improvement of several metabolic parameters due to carob’s rich content of soluble fibers such as galactomannan, fructooligosaccharies, and polyphenols.
 
Pharmactive’s CSAT+ is double standardized to ≥36% galactomannan, to ≥2% FOS and 1% polyphenols, allowing it to perform as a significant natural agent for addressing the needs derived from overweight or obesity, with high-quality standards.
 
These and other studies support CSAT+’s multitarget action and synergic effect on the disorders related to metabolic alterations by helping to regulate blood glucose levels and improve lipid metabolism. Its capacity to control blood glucose also contributes to its ability to help control appetite. “A minimum daily dosage of 300mg of CSAT+ is recommended for weight control, while 1000mg per day is indicated for maximum efficacy,” Julia Diaz, head of marketing for Pharmative, said.
 
Pharmactive derives CSAT+ from regionally grown, non-GMO carob that is processed using no chemicals or solvents. It is certified kosher and halal and canbe used in a number of food and beverage formulations. At 10% or greater concentration, it can form a palatable gel suitable for energy gel supplements favored by consumers active in sports nutrition.
 
“We fully control the supply chain from local farms to supplement to final products, ensuring full food traceability and safety.”