A double-blinded, placebo-controlled study suggests that the source and volume of hyaluronic acid (HA) in the body may help reduce wrinkles.
 
The trial involved 60 healthy men and women between 22 and 59 years of age. The group was divided in three, with subjects administered either a placebo, or a hyaluronic acid formulation using one of two varieties, with a molecular weight of 2k or 300k. Researchers used Hyabest (S)LF-P, from the Japan-based Kewpie Corporation. The dosage, 120 mg daily, was the same for all, and the trial lasted 12 weeks.
 
Within two weeks of completing the course of supplementation, subjects were observed with instrumentation and interviewed via questionnaire. The HA groups reported indisputable changes in the depth and definition of wrinkles, which was substantiated by microphotography, along with notable improvements in luster and suppleness.
 
This new study adds to a 2014 peer-reviewed study published in Nutrition Journal, in which daily intake of Kewpie’s hyaluronan ingredient Hyabest (S)LF-P was shown conclusively to counter the loss of skin hydration and guard against deterioration due to age, and to such environmental factors as cold, dry air and UV radiation. For the first time, daily oral intake of hyaluronic acid, which had been used topically from its debut in the 1930’s, was determined to be a viable means of replenishment in the body.