A study seeking to reduce potential gastrointestinal side effects of antibiotic treatment with probiotic supplementation has found significant benefits from using with HOWARU Restore, part of the DuPont Danisco probiotic range from DuPont Nutrition & Health. The study, which was conducted by DuPont Nutrition & Health in collaboration with Changhai Hospital in Shanghai, was published in Vaccine Journal and is titled, “Clinical Dose Response Study Examines Use of Probiotics to Reduce Symptoms of Antibiotic Use.”
 
The triple-blind, dose-response study concluded that the four-strain probiotic combination in HOWARU Restore appears to lower the risk and duration of antibiotic-associated diarrhea (AAD).  A decrease in gastrointestinal symptoms —fever, bloating and abdominal pain — also was observed compared to the placebo group.
 
The 503 adult subjects were divided into three groups: a placebo group and two groups that received either a low dose or high dose of HOWARU Restore. Both probiotic treatments and the placebo were administered daily in the form of capsules during and for seven days following antibiotic treatment.
 
While the low-dose group clearly experienced fewer antibiotic side effects than the placebo group, the incidence of AAD in the high-dose group was, at 12.5%, close to half that of the placebo group (24.6%). The high-dose group similarly had a considerably lower rate of fever and gastrointestinal discomfort.
 
For more information:www.dupont.com