• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Exclusives
    • Nutraceuticals
    • Markets
    • Health
    • Jobs
    • Events
    • Buyers' Guide
    • Showcases
    • More
  • Magazine
  • News
  • Exclusives
  • Nutraceuticals
  • Markets
  • Health
  • Jobs
  • Events
  • Buyers' Guide
  • Showcases
  • Current & Past Issues
    Features
    Columns
    Editorials
    Digital Edition
    Subscribe Now
    Advertise Now
    eNewsletter
    Editorial Guidelines
    Top Features
    Fueling Cognitive Health through Nutrition & Supplementation

    2020 State of the Industry: High Expectations

    2020 International Buyers' Guide

    Clean Label Questions: Anything But ‘Short and Sweet’

    Key Trends in Functional Foods & Beverages for 2020
    Breaking News
    Certifications, Approvals and Patents
    Exclusives
    Industry & Market News
    People
    Products
    Regulatory
    Research
    Supplier News
    Live From Shows
    Top News
    Deerland Obtains Certification from Australia’s Therapeutic Goods Administration

    OptiMSM Shown to Improve Hair & Nail Appearance and Condition

    DCC Acquires Contract Manufacturer Ion Laboratories

    AquaCelle Delivery Technology Shown to Improve Omega-3 Absorption

    Mintel Identifies Global Food and Drink Trends Over Next 10 Years
    Exclusives
    Blogs & Guest Articles
    Health E-Insights
    Area Code 420
    eBook
    Antioxidants
    Dairy-Based Ingredients
    Enzymes
    Fatty Acids
    Fiber & Carbohydrates
    Green Foods
    Herbs & Botanicals
    Marine Nutraceuticals
    Minerals
    Omega 3s
    Probiotics & Prebiotics
    Proteins, Peptides, Amino Acids
    Sweeteners
    Vitamins

    OptiMSM Shown to Improve Hair & Nail Appearance and Condition

    AquaCelle Delivery Technology Shown to Improve Omega-3 Absorption

    Cannabinoid Testing & Quality: Michael Poleselli on the VivAssure Standard

    Mood33 to Introduce Hemp-Infused Herbal Teas Featuring Evo Hemp

    Elixinol Gains USDA Organic Certification for CBD Tincture
    Consumer Trends
    Contract Manufacturing
    Cosmeceuticals / Nutricosmetics
    Delivery & Dosage Technologies
    Dietary Supplements
    Flavors & Colors
    Functional Foods & Beverages
    Healthcare Trends
    Medical Nutrition
    Mergers & Acquisitions
    Natural/Organic
    Nutrition Bars
    Packaging
    Pet Nutraceuticals
    Quality & Safety
    Regulations
    Research
    Testing
    World Markets

    OptiMSM Shown to Improve Hair & Nail Appearance and Condition

    DCC Acquires Contract Manufacturer Ion Laboratories

    AquaCelle Delivery Technology Shown to Improve Omega-3 Absorption

    Mintel Identifies Global Food and Drink Trends Over Next 10 Years

    Cannabinoid Testing & Quality: Michael Poleselli on the VivAssure Standard
    Bone & Joint Health
    Cancer Risk
    Cardiovascular Health
    Cognitive Function
    Diabetes & Blood Sugar Management
    Digestive Health
    Energy
    Eye Health
    Healthy Aging
    Immune Function
    Infant & Children's Health
    Inflammation
    Men's Health
    Mood Health & Sleep
    Oral Health
    Sexual & Reproductive Health
    Skin Health
    Sports Nutrition
    Weight Management/Weight Loss
    Women's Health

    Pharmactive Affron Saffron May Help Relieve Depression Symptoms

    Maternal 5-MTHF Levels Predict Fetal Folate Status

    Obesity and Gum Disease May Have Common Connection: Inflammation

    Probiotic Strain Shown to Reduce Symptoms of Infant Colic

    Clinical Trial Confirms Joint Health Benefits of NEM Brand Eggshell Membrane in 7 Days
    Industry Events
    Live From Show Events
    Webinars
    All Companies
    Categories
    Trade Associations
    Company Capabilities
    International Buyers Guide Companies
    ExcelVite Sdn. Bhd.

    MitoCarn (Alfasigma)

    Shanghai Freemen

    BatchMaster Software, Inc.

    Barrington Nutritionals
    Companies
    Product Releases
    News Releases
    Literature / Brochures
    White Papers
    Jobs
    VIdeos
    Services
    Add New Company
    International Buyers Guide Companies
    Bioenergy Life Science, Inc. (BLS)

    Aiya America (Matcha by Aiya)

    Sabinsa Corporation

    Barrington Nutritionals

    PLT Health Solutions
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Buyers' Guide
      • All Companies
      • Categories
      • Trade Associations
      • Company Capabilities
    • Nutraceuticals
      • Antioxidants
      • Dairy-Based Ingredients
      • Enzymes
      • Fatty Acids
      • Fiber & Carbohydrates
      • Green Foods
      • Herbs & Botanicals
      • Marine Nutraceuticals
      • Minerals
      • Omega 3s
      • Probiotics & Prebiotics
      • Proteins, Peptides, Amino Acids
      • Sweeteners
      • Vitamins
    • Markets
      • Consumer Trends
      • Contract Manufacturing
      • Cosmeceuticals / Nutricosmetics
      • Delivery & Dosage Technologies
      • Dietary Supplements
      • Flavors & Colors
      • Functional Foods & Beverages
      • Healthcare Trends
      • Medical Nutrition
      • Mergers & Acquisitions
      • Natural/Organic
      • Nutrition Bars
      • Packaging
      • Pet Nutraceuticals
      • Quality & Safety
      • Regulations
      • Research
      • Testing
      • World Markets
    • Health
      • Bone & Joint Health
      • Cancer Risk
      • Cardiovascular Health
      • Cognitive Function
      • Diabetes & Blood Sugar Management
      • Digestive Health
      • Energy
      • Eye Health
      • Healthy Aging
      • Immune Function
      • Infant & Children's Health
      • Inflammation
      • Men's Health
      • Mood Health & Sleep
      • Oral Health
      • Sexual & Reproductive Health
      • Skin Health
      • Sports Nutrition
      • Weight Management/Weight Loss
      • Women's Health
    • Online Exclusives
    • Webinars
    • Slideshows
    • Blogs & Guest Articles
    • Health E-Insights
    • Videos
    • Podcasts
    • eBook
    • Infographics
    • Whitepapers
    • Research
      • TrendSense
      • Monograph Center
      • White Papers
      • Research News
    • Jobs
    • Events
      • Industry Events
      • Live From Show Events
      • Webinars
    • Supplier Showcases
      • Companies
      • Product Releases
      • News Releases
      • Literature / Brochures
      • White Papers
      • Jobs
      • VIdeos
      • Services
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Blog

    Resveratrol Study Could Lead to Solutions for Depression, Anxiety

    Antioxidant found in grape skin displayed neuroprotective effects against corticosterone by inhibiting expression of the enzyme phosphodiesterase 4 (PDE4).

    Resveratrol Study Could Lead to Solutions for Depression, Anxiety
    Related CONTENT
    • Study Confirms Effect of InSea2 on Glycemic Control
    • Oral Solids Endure & Evolve
    • Manufacturing Equipment Technology & Trends
    • High-Fructose Corn Syrup Boosts Intestinal Tumor Growth in Mice
    • GW Pharmaceuticals Receives ABC Tyler Award for Phytomedicinal Research
    08.22.19
    The plant compound resveratrol that’s found in red wine displays anti-stress effects by blocking the expression of an enzyme related to the control of stress in the brain, according to a study published in Neuropharmacology led by researchers at the University at Buffalo.
     
    The findings shed light on how resveratrol impacts neurological processes. According to the Anxiety and Depression Association of America, depression and anxiety disorders affect 16 and 40 million people, respectively, in the U.S.
     
    “Resveratrol may be an effective alternative to drugs for treating patients suffering from depression and anxiety disorders,” said Ying Xu, MD, PhD, co-lead author and research associate professor in the UB School of Pharmacy and Pharmaceutical Sciences.
     
    The study was also led by Xiaoxing Yin, PhD, professor at Xuzhou Medical University in China.
     
    Stress Protection
    Resveratrol, which has been linked to a number of health benefits, is a compound found in the skin and seeds of grapes and berries. While research has identified resveratrol to have antidepressant effects, the compound’s relationship to phosphodiesterase 4 (PDE4), an enzyme influenced by the stress hormone corticosterone, was unknown.
     
    Corticosterone regulates the body’s response to stress. Too much stress, however, can lead to excessive amounts of the hormone circulating in the brain and, ultimately, the development of depression or other mental disorders.
     
    These unknown physiological relationships make drug therapy complex. Current antidepressants instead focus on serotonin or noradrenaline function in the brain, but only one-third of patients with depression enter full remission in response to these medications, said Xu.
     
    In a study on mice, researchers revealed that PDE4, induced by excessive amounts of corticosterone, causes depression- and anxiety-like behavior.
     
    The enzyme lowers cyclic adenosine monophosphate—a messenger molecule that signals physiological changes such as cell division, change, migration and death—in the body, leading to physical alterations in the brain.
     
    Resveratrol displayed neuroprotective effects against corticosterone by inhibiting the expression of PDE4. The research lays the groundwork for the use of the compound in novel antidepressants.
     
    Additional UB investigators include visiting scholar Xia Zhu and graduate student Victor Zheng in the Department of Pharmaceutical Sciences; and James O’Donnell, PhD, dean and professor of the School of Pharmacy and Pharmaceutical Sciences, whose research is focused on identifying novel molecular targets that mediate antidepressant, anti-anxiety and memory-enhancing effects on behavior.
    Related Searches
    • Depression
    • China
    • Enzyme
    • Health
    Related Knowledge Center
    • Research
    • Mood Health & Sleep
    • Antioxidants
    Suggested For You
    ACG Debuts Line of Clean Label, Vegetarian Capsules ACG Debuts Line of Clean Label, Vegetarian Capsules
    Flavonoids May Decrease Risk of Cancer & Heart Disease Flavonoids May Decrease Risk of Cancer & Heart Disease
    AHPA Updates Botanical Safety Handbook AHPA Updates Botanical Safety Handbook
    ConsumerLab Tests Find 19% of B Vitamin Supplements Failed Quality Standard ConsumerLab Tests Find 19% of B Vitamin Supplements Failed Quality Standard
    Consistent Timing of Exercise Tied to Sustaining Physical Activity Consistent Timing of Exercise Tied to Sustaining Physical Activity
    Prebiotic Formulation Benefits Gut, Liver, and Skin Rejuvenation Prebiotic Formulation Benefits Gut, Liver, and Skin Rejuvenation
    Study Finds Dietary Cholesterol or Egg Consumption Unrelated to Stroke Risk Study Finds Dietary Cholesterol or Egg Consumption Unrelated to Stroke Risk
    Omega-3 Expert Supports New Research Showing Health Benefits of Omega-6 Omega-3 Expert Supports New Research Showing Health Benefits of Omega-6
    Too Much Animal Protein Associated with Greater Risk of Death in Men Too Much Animal Protein Associated with Greater Risk of Death in Men
    GW Pharmaceuticals Receives ABC Tyler Award for Phytomedicinal Research GW Pharmaceuticals Receives ABC Tyler Award for Phytomedicinal Research
    High-Fructose Corn Syrup Boosts Intestinal Tumor Growth in Mice High-Fructose Corn Syrup Boosts Intestinal Tumor Growth in Mice
    Oral Solids Endure & Evolve Oral Solids Endure & Evolve
    Manufacturing Equipment Technology & Trends Manufacturing Equipment Technology & Trends
    Study Confirms Effect of InSea2 on Glycemic Control Study Confirms Effect of InSea2 on Glycemic Control

    Related Blog

    • Consumer Trends | Minerals | Proteins, Peptides, Amino Acids | Research | Vitamins | Weight Management/Weight Loss
      High Protein Partial Meal Replacement Diet May Enhance Nutrition Quality for Overweight Consumers

      High Protein Partial Meal Replacement Diet May Enhance Nutrition Quality for Overweight Consumers

      Better understanding of factors underlying nutritional inadequacies could lead to practical solutions and address obesity.
      By Joosang Park, PhD, Principal Scientist, Global Product Science and Safety, Herbalife Nutrition 10.22.19

    • Healthcare Trends | Research
      How to Maintain Trust in Nutrition Science

      How to Maintain Trust in Nutrition Science

      Blue-ribbon panel recommends how to work with various stakeholders to maintain transparency and scientific rigor.
      By Texas A&M AgriLife Communications 02.04.19

    • Antioxidants | Energy | Functional Foods & Beverages | Healthy Aging | Herbs & Botanicals | Immune Function | Skin Health | Sports Nutrition | Weight Management/Weight Loss
      Defining the Health Benefits & Functionality of Tea

      Defining the Health Benefits & Functionality of Tea

      Are ready-to-drink teas as healthy as consumers think?
      By Youngmok Kim, PhD, Senior Research Scientist, Synergy Flavors 12.19.17


    • Antioxidants | Natural/Organic | Quality & Safety | Regulations | World Markets
      Brexit Implications for Organic Trade

      Brexit Implications for Organic Trade

      The first impact of Brexit will be an increased workload for regulators, policy lawyers and specialists.
      Hope Lee, Senior Analyst, Beverages, Euromonitor International 07.05.16

    • Antioxidants | Cardiovascular Health | Confectionery | Consumer Trends | Healthcare Trends | Minerals | Regulations | Vitamins | World Markets
      The New Eatwell Guide: In Tune With U.K. Eating Habits?

      The New Eatwell Guide: In Tune With U.K. Eating Habits?

      Public perception sometimes runs counter to nutrition science.
      Simone Baroke, Contributing Analyst, Euromonitor International 04.20.16

    • Diabetes & Blood Sugar Management | Enzymes | Healthcare Trends | Research
      Links Between One-Carbon Metabolism & Obesity

      Links Between One-Carbon Metabolism & Obesity

      There has been increasing interest in the role of epigenetics in the development of this complex condition.
      Lorena Carboni, Product Support Specialist, Gnosis S.p.A. 02.01.16


    • Cardiovascular Health | Diabetes & Blood Sugar Management | Digestive Health | Healthcare Trends | Research
      It Takes ‘Guts’ to Stop Eating:
 Obesity & The Microbiome

      It Takes ‘Guts’ to Stop Eating:
 Obesity & The Microbiome

      Future research should investigate how crucial gut microbes interact with our intrinsic regulatory mechanisms.
      William B. Miller, Jr. MD 01.20.16

    • Dietary Supplements | Digestive Health | Regulations | Research
      Lessons For Industry From Bayer’s Victory

      Lessons For Industry From Bayer’s Victory

      The Court’s decision in U.S. v. Bayer is welcome news to industry.
      Jonathan F. Cohn, Partner, and Benjamin M. Mundel, Associate, of Sidley Austin LLP 11.10.15

    • Cognitive Function | Functional Foods & Beverages | Inflammation | Natural/Organic | Research
      Alzheimer’s Prevention Through Nutrition

      Alzheimer’s Prevention Through Nutrition

      Dr. Perlmutter outlines how to promote brain health through food.
      Dr. David Perlmutter, MD, FACN, ABIHM 11.05.15


    • Healthcare Trends | Natural/Organic | Quality & Safety | Regulations | Research
      Genetic Engineering & GMOs: What You Rarely Hear

      Genetic Engineering & GMOs: What You Rarely Hear

      An overwhelming majority of scientists from credible organizations support the safety of these crops and food.
      Lisa Katic, RD 10.30.15

    • Cardiovascular Health | Confectionery | Consumer Trends | Diabetes & Blood Sugar Management | Healthcare Trends | Research | World Markets
      Mediterranean Diet Falls Victim to the Lure of Convenience

      Mediterranean Diet Falls Victim to the Lure of Convenience

      Obesity rates are on the rise in virtually all of the countries surrounding the Mediterranean Sea.
      Simone Baroke, Contributing Analyst, Euromonitor International 09.10.15

    • Antioxidants | Cognitive Function | Delivery & Dosage Technologies | Functional Foods & Beverages | Minerals | Natural/Organic | Vitamins | World Markets
      What’s Next in Health & Wellness Bottled Water?

      What’s Next in Health & Wellness Bottled Water?

      Fortified products have been a bright spot for sluggish bottled water sales overall.
      Simone Baroke, Contributing Analyst, Euromonitor International 08.17.15

    • Bone & Joint Health | Cardiovascular Health | Diabetes & Blood Sugar Management | Dietary Supplements | Functional Foods & Beverages | Healthcare Trends | Healthy Aging | Infant & Children's Health | Inflammation | Quality & Safety | Research | Vitamins | Women's Health
      Vitamin D: A Cheap & Effective Weapon Against Chronic Disease?

      Vitamin D: A Cheap & Effective Weapon Against Chronic Disease?

      The writing on the wall suggests it may be vitamin D’s time to shine.
      Ewa Hudson, Head of Health & Wellness Research, Euromonitor International 06.16.15

    • Antioxidants | Cancer Risk | Cardiovascular Health | Cognitive Function | Healthy Aging | Inflammation | Natural/Organic
      Strawberries: A Standout Superfruit

      Strawberries: A Standout Superfruit

      Rich in anthocyanins, strawberries pack a heart-healthy, fat-busting punch.
      Carl Thompson, Contributing Writer 06.10.15

    • Antioxidants | Diabetes & Blood Sugar Management | Fatty Acids | Minerals | Research | Vitamins
      Strawberries May Help Improve Insulin Sensitivity

      Strawberries May Help Improve Insulin Sensitivity

      Consumption of freeze dried strawberry containing beverage led to a significant decrease in peak post meal insulin.
      Saba Sassouni, MS, RD, CDN, Lead Dietician of Zone Manhattan 05.08.15

    Breaking News
    • Deerland Obtains Certification from Australia’s Therapeutic Goods Administration
    • OptiMSM Shown to Improve Hair & Nail Appearance and Condition
    • DCC Acquires Contract Manufacturer Ion Laboratories
    • AquaCelle Delivery Technology Shown to Improve Omega-3 Absorption
    • Mintel Identifies Global Food and Drink Trends Over Next 10 Years
    View Breaking News >
    CURRENT ISSUE

    December 2019

    • 2020 International Buyers' Guide
    • 2020 State of the Industry: High Expectations
    • Fueling Cognitive Health through Nutrition & Supplementation
    • View More >
    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Deerland Obtains Certification from Australia’s Therapeutic Goods Administration
    OptiMSM Shown to Improve Hair & Nail Appearance and Condition
    DCC Acquires Contract Manufacturer Ion Laboratories
    Coatings World

    Latest Breaking News From Coatings World

    Arkema: Bostik Acquires Danish Company LIP
    Axalta Adds New Epoxy Primer to Tufcote Liquid Industrial Coatings Portfolio
    Chromaflo Technologies Promotes Sergio Duenas to Country Manager of Mexico
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    FDA OKs World's First Single-Use Duodenoscope
    Dr. Stephen Hahn Confirmed as New FDA Leader
    FDA OKs First Test to Help Screen for Newborn Duchenne Muscular Dystrophy
    Contract Pharma

    Latest Breaking News From Contract Pharma

    Sanofi Awarded $226M by US Gov't for Pandemic Influenza Preparedness
    Amgen Selects Location For R&D Facility
    Arctoris Opens Oxford R&D Facility
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Time Features 5 Best Beauty Inventions
    CES 2020 Preview - Innovation Award Honorees in Health & Wellness
    Prada & L’Oréal Sign Long-Term Licensing Deal
    Happi

    Latest Breaking News From Happi

    Cosmetic Assessments Revealed at CIR Panel
    T-Boz Launches CBD Line
    DRF and Flowerkist Develop CBD Range
    Ink World

    Latest Breaking News From Ink World

    Ripon Printers Adds Ricoh Pro C9210
    LogoJet Opens Bogota, Colombia Office
    Canon Solutions America Powers University of Notre Dame Athletics' Printing Capabilities
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    GSE products provide quality assurance for Pharmalabel
    Luminer promotes Heather Bookman to prepress manager
    Materials Exchange launches to solve excess inventory issue
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Bouckaert to Launch New Equipment
    DuPont to Acquire Osmosis Specialist
    Nice-Pak to Expand in Indiana
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    FDA OKs First Test to Help Screen for Newborn Duchenne Muscular Dystrophy
    Europe, North America Comprise More Than 80 Percent of Global Bone Marrow Transplantation Demand
    TriMed Closes Out FDA Warning Letter
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    3D Printing Materials Market to Grow at 23.9% CAGR Through 2025: GVR
    Kyocera, TactoTek Collaborate on Injection Molded Structural Electronics Solutions
    Toray Opens R&D Innovation Center for the Future

    Copyright © 2019 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.