02.13.12
Cypress Systems has announced that additional research has been published indicating that selenium forms vary and that high-selenium yeast such as SelenoExcell from Cypress Systems, is the most effective form. The effect of selenium enrichment on baker's yeast proteome was published in the Journal of Proteomics in January by Karam El-Bayoumy et. al. from the Penn State College of Medicine in Hershey, PA.
In the study, the use of regular yeast (RY) and selenium-enriched yeast (SEY) as a dietary supplement is of interest because the Nutritional Prevention of Cancer trial revealed that SEY, but not RY, decreased the incidence of prostate cancer. Using two-dimensional difference in gel electrophoresis (2D-DIGE)-tandem mass spectrometry (MS/MS) approach, the researchers performed proteomic analysis of RY and SEY to identify proteins that are differentially expressed as a result of selenium enrichment.
The expression profile of five of the proteins with validated or putative roles in the carcinogenesis process, and for which antibodies against human forms of the proteins are available commercially was verified by western analysis. This study provides evidence for the first time that SEY contains higher levels of Pyruvate Kinase, HSP70 and Elongation factor 2 and lower levels of Eukaryotic Translation Initiation Factor 5A-2 and Triosephosphate Isomerase than those found in RY. The quantitative measurements of these five proteins are often used as biomarkers in predicting and understanding carcinogenesis. For further information www.cypsystems.com
In the study, the use of regular yeast (RY) and selenium-enriched yeast (SEY) as a dietary supplement is of interest because the Nutritional Prevention of Cancer trial revealed that SEY, but not RY, decreased the incidence of prostate cancer. Using two-dimensional difference in gel electrophoresis (2D-DIGE)-tandem mass spectrometry (MS/MS) approach, the researchers performed proteomic analysis of RY and SEY to identify proteins that are differentially expressed as a result of selenium enrichment.
The expression profile of five of the proteins with validated or putative roles in the carcinogenesis process, and for which antibodies against human forms of the proteins are available commercially was verified by western analysis. This study provides evidence for the first time that SEY contains higher levels of Pyruvate Kinase, HSP70 and Elongation factor 2 and lower levels of Eukaryotic Translation Initiation Factor 5A-2 and Triosephosphate Isomerase than those found in RY. The quantitative measurements of these five proteins are often used as biomarkers in predicting and understanding carcinogenesis. For further information www.cypsystems.com