03.01.12
Nutraceutical: Dietary fiber/whole grains
Indication: Colon cancer
Source: BMJ, November 10, 2011;343:d6617.
Research: This study investigated the association between intake of dietary fiber and whole grains and risk of colorectal cancer. Researchers evaluated prospective cohort and nested case-control studies of dietary fiber or whole grain intake and incidence of colorectal cancer.
Results: Twenty-five prospective studies were included in the analysis. The summary relative risk of developing colorectal cancer for 10 grams daily of total dietary fiber (16 studies) was 0.90 (95% confidence interval 0.86 to 0.94, I(2)=0%), for fruit fiber (n=9) was 0.93 (0.82 to 1.05, I(2)=23%), for vegetable fiber (n=9) was 0.98 (0.91 to 1.06, I(2)=0%), for legume fiber (n=4) was 0.62 (0.27 to 1.42, I(2)=58%) and for cereal fiber (n=8) was 0.90 (0.83 to 0.97, I(2)=0%). The summary relative risk for an increment of three servings daily of whole grains (n=6) was 0.83 (0.78 to 0.89, I(2)=18%). A high intake of dietary fiber, in particular cereal fiber and whole grains, was associated with a reduced risk of colorectal cancer. Further studies should report more detailed results, including those for subtypes of fiber and be stratified by other risk factors to rule out residual confounding, researchers concluded. Further assessment of the impact of measurement errors on the risk estimates is also warranted.
Indication: Colon cancer
Source: BMJ, November 10, 2011;343:d6617.
Research: This study investigated the association between intake of dietary fiber and whole grains and risk of colorectal cancer. Researchers evaluated prospective cohort and nested case-control studies of dietary fiber or whole grain intake and incidence of colorectal cancer.
Results: Twenty-five prospective studies were included in the analysis. The summary relative risk of developing colorectal cancer for 10 grams daily of total dietary fiber (16 studies) was 0.90 (95% confidence interval 0.86 to 0.94, I(2)=0%), for fruit fiber (n=9) was 0.93 (0.82 to 1.05, I(2)=23%), for vegetable fiber (n=9) was 0.98 (0.91 to 1.06, I(2)=0%), for legume fiber (n=4) was 0.62 (0.27 to 1.42, I(2)=58%) and for cereal fiber (n=8) was 0.90 (0.83 to 0.97, I(2)=0%). The summary relative risk for an increment of three servings daily of whole grains (n=6) was 0.83 (0.78 to 0.89, I(2)=18%). A high intake of dietary fiber, in particular cereal fiber and whole grains, was associated with a reduced risk of colorectal cancer. Further studies should report more detailed results, including those for subtypes of fiber and be stratified by other risk factors to rule out residual confounding, researchers concluded. Further assessment of the impact of measurement errors on the risk estimates is also warranted.