03.01.10
Scientists at McLean Hospital and professors at Harvard Medical School have explored the effects of Cognizin citicoline, from Kyowa Hakko, on the neurobiological systems involved in appetite and eating behavior regulation. Results indicate a potential to reduce cravings and increase feelings of satiety. This work was published in the January issue of the International Journal of Eating Disorders.
This study compared the effects of open label treatment with citicoline at two different dosages (500 mg/day versus 2000 mg/day) for six weeks on changes in appetite ratings (using questionnaires), weight and brain response to images of high-calorie foods (using magnetic resonance imaging).
In the stimulation phases of the study, at baseline and following the six-week treatment, participants were monitored via MRI while viewing a series of colorful visuals that included both high-calorie foods and non-food objects in a quick 150-second series of photos. Each image was viewed for a brief, three seconds. Study participants included 16 healthy adults (eight men, eight women) ranging from 40 to 57 years of age, and across a range of Body Mass Index values from 20 to 38.
Appetite ratings declined significantly for the group as a whole, as assessed by questionnaire responses. The decline for the high-dose group did reach significance, however, the low-dose group did not. There was no significant change in weight for either group overall, although individuals did show weight loss. For further information: www.kyowa-usa.com
This study compared the effects of open label treatment with citicoline at two different dosages (500 mg/day versus 2000 mg/day) for six weeks on changes in appetite ratings (using questionnaires), weight and brain response to images of high-calorie foods (using magnetic resonance imaging).
In the stimulation phases of the study, at baseline and following the six-week treatment, participants were monitored via MRI while viewing a series of colorful visuals that included both high-calorie foods and non-food objects in a quick 150-second series of photos. Each image was viewed for a brief, three seconds. Study participants included 16 healthy adults (eight men, eight women) ranging from 40 to 57 years of age, and across a range of Body Mass Index values from 20 to 38.
Appetite ratings declined significantly for the group as a whole, as assessed by questionnaire responses. The decline for the high-dose group did reach significance, however, the low-dose group did not. There was no significant change in weight for either group overall, although individuals did show weight loss. For further information: www.kyowa-usa.com