07.01.07
Indication: Age-related macular degeneration (AMD)
Source: Arch Ophthalmol, May 2007;125(5):671-9.
Research: Researchers set out to evaluate the association of lipid intake with baseline severity of AMD in the Age-Related Eye Disease Study (AREDS). This study included over 4500 participants aged 60 to 80 years at enrollment, who provided estimates of habitual nutrient intake through a self-administered semi-quantitative food frequency questionnaire. Stereoscopic color fundus photographs were used to categorize participants into four AMD severity groups and a control group (participants with <15 small drusen).
Results: Of the 4519 subjects, 1115 patients had no symptoms of disease at the outset, while 658 people had a severe form of the disease. When their diets were evaluated, the researchers found that people who ate more fish—more than two medium servings per week or more than one serving of broiled or baked fish—were least likely to have the disease. More specifically, dietary total omega 3 long-chain polyunsaturated fatty acid (LCPUFA) intake was inversely associated with neovascular (NV) AMD, as was docosahexaenoic acid (DHA), a retinal omega 3 LCPUFA. Dietary arachidonic acid was directly associated with NV AMD prevalence, but no statistically significant relationships existed for the other lipids or AMD groups.
Source: Arch Ophthalmol, May 2007;125(5):671-9.
Research: Researchers set out to evaluate the association of lipid intake with baseline severity of AMD in the Age-Related Eye Disease Study (AREDS). This study included over 4500 participants aged 60 to 80 years at enrollment, who provided estimates of habitual nutrient intake through a self-administered semi-quantitative food frequency questionnaire. Stereoscopic color fundus photographs were used to categorize participants into four AMD severity groups and a control group (participants with <15 small drusen).
Results: Of the 4519 subjects, 1115 patients had no symptoms of disease at the outset, while 658 people had a severe form of the disease. When their diets were evaluated, the researchers found that people who ate more fish—more than two medium servings per week or more than one serving of broiled or baked fish—were least likely to have the disease. More specifically, dietary total omega 3 long-chain polyunsaturated fatty acid (LCPUFA) intake was inversely associated with neovascular (NV) AMD, as was docosahexaenoic acid (DHA), a retinal omega 3 LCPUFA. Dietary arachidonic acid was directly associated with NV AMD prevalence, but no statistically significant relationships existed for the other lipids or AMD groups.