07.01.05
Indication: Colon cancer
Source: J Natl Cancer Inst, May 2005;9(97):684-692.
Research: Investigators conducted a prospective nested case-control study of 32,826 female participants of the Nurses’ Health Study who provided blood specimens in 1989-1990. They analyzed the blood for levels of pyridoxal 5’-phosphate (PLP), which is the primary active form of vitamin B6.
Results: Researchers found the study group later developed 194 cases of colorectal cancer and 410 cases of colon polyps. To determine whether PLP had an effect on these conditions, participants’ blood results were divided into four groups from lowest to highest blood levels of PLP; the highest quartile group showed a 44% lower risk of colorectal cancer and colorectal polyps and a 58% lower risk of colon cancer and colon polyps. The highest intake group had a median of 8.6 mg per day of PLP compared to 1.6 mg per day in the lowest intake group, near the RDA of vitamin B6 for adult men and women (2.0 mg per day and 1.6 mg per day, respectively). Researchers concluded that vitamin B6 supplementation may be associated with a lower risk of colon cancer and colorectal cancer formation.
Source: J Natl Cancer Inst, May 2005;9(97):684-692.
Research: Investigators conducted a prospective nested case-control study of 32,826 female participants of the Nurses’ Health Study who provided blood specimens in 1989-1990. They analyzed the blood for levels of pyridoxal 5’-phosphate (PLP), which is the primary active form of vitamin B6.
Results: Researchers found the study group later developed 194 cases of colorectal cancer and 410 cases of colon polyps. To determine whether PLP had an effect on these conditions, participants’ blood results were divided into four groups from lowest to highest blood levels of PLP; the highest quartile group showed a 44% lower risk of colorectal cancer and colorectal polyps and a 58% lower risk of colon cancer and colon polyps. The highest intake group had a median of 8.6 mg per day of PLP compared to 1.6 mg per day in the lowest intake group, near the RDA of vitamin B6 for adult men and women (2.0 mg per day and 1.6 mg per day, respectively). Researchers concluded that vitamin B6 supplementation may be associated with a lower risk of colon cancer and colorectal cancer formation.