01.04.13
LifeVantage Corporation’s Protandim, an ingredient comprised of five highly synergistic herbal ingredients, has been shown in earlier studies to activate the transcription factor Nrf2, a signal to the cell's DNA to regulate a network of protective genes. The new study further investigates Protandim's ability to induce protective responses in cultured mouse heart muscle cells.
The study found that Protandim treatment of cultured HL-1 cells (mouse cardiomyocytes) caused Nrf2 activation, as measured by nuclear accumulation of Nrf2 and by increased expression of phase II enzymes heme oxygenase-1, superoxide dismutase-1 and glutathione reductase.
Additionally, Protandim treatment of cultured HL-1 cells caused protection against hydrogen peroxide-induced apoptosis, and it was shown that the Nrf2 pathway was required for this protective effect.
Furthermore, exposure of HL-1 cells to oxidative stress activates Nrf2, but treatment of HL-1 cells with Protandim activates Nrf2 more robustly than does oxidative stress. “This is important,” noted Darlene Walley, Ph.D., LifeVantage Chief Science Officer, “because it supports the hypothesis that Protandim may protect heart cells against oxidative challenges above and beyond the natural adaptive responses by cells to oxidative stress.”
For further information: http://www.sciencedirect.com/science/article/pii/S0891584912018254
The study found that Protandim treatment of cultured HL-1 cells (mouse cardiomyocytes) caused Nrf2 activation, as measured by nuclear accumulation of Nrf2 and by increased expression of phase II enzymes heme oxygenase-1, superoxide dismutase-1 and glutathione reductase.
Additionally, Protandim treatment of cultured HL-1 cells caused protection against hydrogen peroxide-induced apoptosis, and it was shown that the Nrf2 pathway was required for this protective effect.
Furthermore, exposure of HL-1 cells to oxidative stress activates Nrf2, but treatment of HL-1 cells with Protandim activates Nrf2 more robustly than does oxidative stress. “This is important,” noted Darlene Walley, Ph.D., LifeVantage Chief Science Officer, “because it supports the hypothesis that Protandim may protect heart cells against oxidative challenges above and beyond the natural adaptive responses by cells to oxidative stress.”
For further information: http://www.sciencedirect.com/science/article/pii/S0891584912018254